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Sokolova AO , Obeid EI , Cheng HH
Genetic Contribution to Metastatic Prostate Cancer
Urol Clin North Am. 2021 Aug;48(3) :349-363
PMID: 34210490   
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Recent studies show that the prevalence of germline pathogenic and likely pathogenic variants (also known as mutations) in DNA repair genes in metastatic prostate cancer is higher than previously recognized and higher than in unaffected men. Specific gene dysfunction is important in prostate cancer initiation and/or evolution to metastases. This article reviews key literature on individual genes, recognizing BRCA2 as the gene most commonly altered in the metastatic setting. This article discusses the importance of representative and diverse inclusion, and efforts to advance management for at-risk carrier populations to maximize clinical benefit.
1558-318x Sokolova, Alexandra O Obeid, Elias I Cheng, Heather H Journal Article Review United States Urol Clin North Am. 2021 Aug;48(3):349-363. doi: 10.1016/j.ucl.2021.03.005. Epub 2021 Jun 10.