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Santerre M , Arjona SP , Allen CN , Shcherbik N , Sawaya BE
Why do SARS-CoV-2 NSPs rush to the ER?
J Neurol. 2021 Jun;268(6) :2013-2022
PMID: 32870373    PMCID: PMC7461160    URL: https://www.ncbi.nlm.nih.gov/pubmed/32870373
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SARS-CoV-2, which led to the 2020 global pandemic, is responsible for the Coronavirus Disease 2019 (COVID-19), a respiratory illness, and presents a tropism for the central nervous system. Like most members of this family, the virus is composed of structural and non-structural proteins (NSPs). The non-structural proteins are critical elements of the replication and transcription complex (RTC), as well as immune system evasion. Through hijacking the endoplasmic reticulum (ER) membrane, NSPs help the virus establish the RTC, inducing ER stress after membrane rearrangement and causing severe neuronal disturbance. In this review, we focus on the role of Nsp3, 4, and 6 in intracellular membrane rearrangement and evaluate the potential disruption of the central nervous system and the neurodegeneration which it could trigger. Studies of these NSPs will not only bring to light their specific role in viral infection but also facilitate the discovery of novel targeted drugs.
1432-1459 Santerre, Maryline Arjona, Sterling P Allen, Charles Ns Shcherbik, Natalia Sawaya, Bassel E Orcid: 0000-0002-6034-7343 R01 AG054411/AG/NIA NIH HHS/United States R01-AG054411/AG/NIA NIH HHS/United States Journal Article Review J Neurol. 2021 Jun;268(6):2013-2022. doi: 10.1007/s00415-020-10197-8. Epub 2020 Sep 1.