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Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer
Head Neck. 2021 Jun 24;43(10) :3042-3052
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BACKGROUND: Management of hypopharynx cancer is often extrapolated from larynx cancer. This report analyses treatment patterns and survival limited to hypopharynx cancer using the National Cancer Database (NCDB). METHODS: There are 9314 patients diagnosed with hypopharynx cancer between 2004 and 2016. The association between treatment modality and survival was analyzed using Kaplan-Meier survival curves and multivariable Cox regression. RESULTS: Five-year overall survival ranged from 45% for stage I to 21% for stage IVB. Treatment modality did not influence survival in stage I/II. For stage III/IV, chemoradiation and surgery + adjuvant therapy were equivalent. Surgery yielded improved survival for T4 disease. Human papillomavirus (HPV)-positive tumors were present in 21% and were associated with improved hazard ratio of death (0.60, p = <0.0001). CONCLUSIONS: Survival is superior for T4 hypopharynx cancer managed with surgery, while treatment modality does not impact outcomes for other T-stages. HPV-positive tumors are associated with improved survival regardless of treatment.
1097-0347 Burbure, Nina Orcid: 0000-0002-9460-0730 Handorf, Elizabeth Ridge, John A Bauman, Jessica Orcid: 0000-0001-8691-0387 Liu, Jeffrey C Orcid: 0000-0001-8377-0905 Giri, Anshu Galloway, Thomas J Orcid: 0000-0002-5730-2099 Journal Article United States Head Neck. 2021 Jun 24. doi: 10.1002/hed.26793.