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Brown JC , Sarwer DB , Troxel AB , Sturgeon K , DeMichele AM , Denlinger CS , Schmitz KH
A randomized trial of exercise and diet on body composition in survivors of breast cancer with overweight or obesity
Breast Cancer Res Treat. 2021 Jun 5;189(1) :145-154
PMID: 34089422    PMCID: PMC8316406    URL: https://www.ncbi.nlm.nih.gov/pubmed/34089422
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Abstract
PURPOSE: Obesity increases the risk of cancer recurrence and death in survivors of breast cancer. This study tested the hypothesis that exercise alone, diet alone, and the combination of exercise plus diet reduce body weight and improve body composition in survivors of breast cancer. METHODS: In this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to one of four treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. Endpoints included body weight and body composition measured by dual-energy x-ray absorptiometry. RESULTS: After 52 weeks, compared with control, diet alone [- 5.39 kg (95% CI - 7.24, - 3.55);- 6.0% (95% CI - 8.0, - 3.9)] and exercise plus diet [- 6.68 kg (95% CI - 8.46, - 4.90);- 7.4% (95% CI - 9.4, - 5.4)] reduced body weight; exercise alone did not change body weight. Compared with control, diet alone [- 3.59 kg (95% CI - 5.00, - 2.17)] and exercise plus diet [- 4.28 kg (95% CI - 5.71, - 2.84)] reduced fat mass; exercise alone did not change fat mass. Compared with control, diet alone [- 0.82 kg (95% CI - 1.50, - 0.15)] and exercise plus diet [- 1.24 kg (95% CI - 1.92, - 0.56)] reduced lean mass; exercise alone did not change lean mass. Compared with control, exercise alone, diet alone, and exercise plus diet did not change bone mineral density. CONCLUSION: In survivors of breast cancer with overweight or obesity, diet alone or diet plus exercise produced clinically meaningful weight loss at week 52. The majority of weight loss was fat mass.
Notes
1573-7217 Brown, Justin C Orcid: 0000-0001-7540-4913 Sarwer, David B Troxel, Andrea B Sturgeon, Kathleen DeMichele, Angela M Denlinger, Crystal S Schmitz, Kathryn H R00-CA218603/CA/NCI NIH HHS/United States R25 CA203650/CA/NCI NIH HHS/United States R00 CA218603/CA/NCI NIH HHS/United States P30-CA006927/CA/NCI NIH HHS/United States P30-CA016520/CA/NCI NIH HHS/United States UL1-TR001878/CA/NCI NIH HHS/United States U54-CA155850/CA/NCI NIH HHS/United States Journal Article Netherlands Breast Cancer Res Treat. 2021 Jun 5. doi: 10.1007/s10549-021-06284-7.