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Brown JC , Sarwer DB , Troxel AB , Sturgeon K , DeMichele AM , Denlinger CS , Schmitz KH
A randomized trial of exercise and diet on health-related quality of life in survivors of breast cancer with overweight or obesity
Cancer. 2021 Oct 15;127(20) :3856-3864
PMID: 34161602 PMCID: PMC8478822 URL: https://www.ncbi.nlm.nih.gov/pubmed/34161602
AbstractBACKGROUND: Obesity is a chronic, relapsing, and progressive disease; it is associated with poor health-related quality of life (HRQOL) in survivors of breast cancer. METHODS: In this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to 1 of 4 treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. HRQOL end points were measured at baseline and at week 52 using the 36-Item Medical Outcomes Survey-Short Form (SF-36). Repeated measures analysis of covariance quantified the estimated treatment difference (ETD). RESULTS: At baseline, participants had a mean (SD) age of 59.4 years (8.7), body mass index of 34.0 kg/m(2) (5.9), and 71 participants (20.2%) self-reported fair or poor general health. After 52 weeks, compared with control, the exercise plus diet improved the physical health summary score (ETD: 5.39; 95% CI, 0.55-10.22); exercise alone (ETD: -1.91; 95% CI, -6.60 to 2.79) and diet alone (ETD: 3.16; 95% CI, -1.52 to 7.83) did not change the physical health summary score. Compared with control, exercise alone (ETD: -0.27; 95% CI, -6.60 to 2.79), diet alone (ETD: 3.25; 95% CI, -1.41 to 7.91), and the exercise plus diet (ETD: 1.75; 95% CI, -2.90 to 6.39) did not change the mental health summary score. Exercise alone did not impact any HRQOL subscale; diet alone improved the vitality subscale; exercise plus diet improved the physical functioning, role-physical and vitality subscales. CONCLUSION: In survivors of breast cancer with overweight or obesity, exercise plus diet improved select HRQOL end points at week 52.
Notes1097-0142 Brown, Justin C Orcid: 0000-0001-7540-4913 Sarwer, David B Troxel, Andrea B Sturgeon, Kathleen DeMichele, Angela M Denlinger, Crystal S Schmitz, Kathryn H UL1-TR001878/TR/NCATS NIH HHS/United States P30-CA006927/CA/NCI NIH HHS/United States P30-CA016520/CA/NCI NIH HHS/United States U54-CA155850/CA/NCI NIH HHS/United States Journal Article United States Cancer. 2021 Jun 23. doi: 10.1002/cncr.33752.