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Mystery Checkpoint Revealed: KIR3DL3 Finally Found a Ligand in HHLA2
Cancer Immunol Res. 2021 Feb;9(2) :128
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Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2(+) tumor cells from immune attack.See article by Bhatt et al., p. 156.
2326-6074 Campbell, Kerry S Journal Article United States Cancer Immunol Res. 2021 Feb;9(2):128. doi: 10.1158/2326-6066.CIR-20-0996.