FCCC LOGO Faculty Publications
McDonald JA , Cherubin S , Goldberg M , Wei Y , Chung WK , Schwartz LA , Knight JA , Schooling CM , Santella RM , Bradbury AR , Buys SS , Andrulis IL , John EM , Daly MB , Terry MB
Common Childhood Viruses and Pubertal Timing: The LEGACY Girls Study
Am J Epidemiol. 2021 May 4;190(5) :766-778
PMID: 33128063    PMCID: PMC8096486    URL: https://www.ncbi.nlm.nih.gov/pubmed/33128063
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Abstract
Earlier pubertal development is only partially explained by childhood body mass index (BMI); the role of other factors like childhood infections is less understood. Using data from the LEGACY Girls Study (2011 - 2016), we prospectively examined the associations between childhood viral infections (Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Herpes Simplex Virus 1 (HSV1), HSV2 and pubertal timing. We measured exposures based on seropositivity in pre-menarcheal girls (n=490). Breast and pubic hair development were classified based on mother-reported Tanner Stage (TS: TS2+ compared with TS1), adjusting for age, BMI, and sociodemographic factors. The average age at first blood draw was 9.8 years (Stdev=1.9 years). The prevalences were 31% CMV+, 37% EBV+, 14% HSV1+, 0.4% HSV2+, and 16% for both CMV+/EBV+. CMV+ infection without co-infection was associated with developing breasts an average of 7 months earlier (Hazard Ratio (HR)=2.12, 95% CI 1.32, 3.40). CMV+ infection without co-infection and HSV1+ and/or HSV2+ infection were associated with developing pubic hair 9 months later (HR 0.41, 95% CI 0.24, 0.71, HR 0.42, 95% CI 0.22, 0.81, respectively). Infection was not associated with menarche. If replicated in larger cohorts with blood collection prior to any breast development, this study supports that childhood infections may play a role in altering pubertal timing.
Notes
1476-6256 McDonald, Jasmine A Cherubin, Sinaida Goldberg, Mandy Wei, Ying Chung, Wendy K Schwartz, Lisa A Knight, Julia A Schooling, C Mary Santella, Regina M Bradbury, Angela R Buys, Saundra S Andrulis, Irene L John, Esther M Daly, Mary B Terry, Mary Beth Journal Article United States Am J Epidemiol. 2020 Oct 31:kwaa240. doi: 10.1093/aje/kwaa240.