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Cao J , Bhatnagar S , Wang J , Qi X , Prabha S , Panyam J
Cancer stem cells and strategies for targeted drug delivery
Drug Deliv Transl Res. 2020 Oct 23
PMID: 33095384    PMCID: PMC8062588    URL: https://www.ncbi.nlm.nih.gov/pubmed/33095384
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Abstract
Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.
Notes
2190-3948 Cao, Jin Bhatnagar, Shubhmita Wang, Jiawei Qi, Xueyong Prabha, Swayam Panyam, Jayanth NIH R01EB019893/NH/NIH HHS/United States Journal Article Review United States Drug Deliv Transl Res. 2020 Oct 23. doi: 10.1007/s13346-020-00863-9.