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Dubey B , Jackson M , Zeigler-Johnson C , Devarajan K , Flores-Obando RE , McFarlane-Anderson N , Tulloch-Reid M , Aiken W , Kimbro K , Reed D , Kidd LR , Gibbs D , Kumar S , Ragin C
Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men
Prostate. 2020 nov;80(15) :1365-1372
PMID: 32894795    PMCID: PMC7710572    URL: https://www.ncbi.nlm.nih.gov/pubmed/32894795
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BACKGROUND: Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR-related SNPs in relation to PC risk among Jamaican men. METHODS: This case-control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses. RESULTS: Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04-1>.12; p < .001) and IRF3_rs2304206 GG genotype (OR = 0.47; 95% CI: 0.29-0<.78; p = .003) modulated PC risk in people with history of STIs. In the population with no history of STIs, resulting interactions between risk factors did not survive correction for multiple hypothesis testing. CONCLUSION: Overall, an interaction between the IFR3_rs2304206 variant and a history of exposure to STIs leads to greater decrease of PC risk than the presence of polymorphic genotype alone. These findings are suggestive and require further validation. Identification of gene variants along with detection of lifestyle behaviors may contribute to identification of men at a greater risk of PC development in the population.
1097-0045 Dubey, Bhawna Jackson, Maria Orcid: 0000-0002-7031-7244 Zeigler-Johnson, Charnita Devarajan, Karthik Flores-Obando, Rafael E McFarlane-Anderson, Norma Tulloch-Reid, Marshall Aiken, William Kimbro, Kevin Reed, Dominique Orcid: 0000-0003-3982-2653 Kidd, LaCreis R Gibbs, Denise Kumar, Sudhir Ragin, Camille Orcid: 0000-0003-0816-4942 [HSF19]/National Health Fund/ P20-MD000175/MD/NIMHD NIH HHS/United States U54-MD012392/MD/NIMHD NIH HHS/United States CA006927/CA/NCI NIH HHS/United States CA138017/CA/NCI NIH HHS/United States R13 CA130596/CA/NCI NIH HHS/United States PIOJ-77/854/CHASE Fund, the Planning Institute of Jamaica/ Journal Article United States Prostate. 2020 Sep 7. doi: 10.1002/pros.24067.