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Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
Molecular and Cellular Oncology. 2020 ;7(5) :1786345
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Abstract
We recently developed a Brca1 coiled-coil mutant mouse model (Brca1(CC) ). Brca1(CC/CC) results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1(CC/CC) cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with Brca1(Delta11) generated Brca1 (CC/Delta11) mice that were developmentally normal.
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Export Date: 10 August 2020