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Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome
Urol Case Rep. 2020 Mar;29 :101077
PMID: 31853444 PMCID: PMC6911965
AbstractStauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.
NotesZarrabi, Kevin Masic, Selma Schaefer, Christopher Bartel, Michael J Kutikov, Alexander Zibelman, Matthew Case Reports United States Urol Case Rep. 2019 Nov 25;29:101077. doi: 10.1016/j.eucr.2019.101077. eCollection 2020 Mar.