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Leystra AA , Clapper ML
Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer
Genes (Basel). 2019 Nov 7;10(11)
PMID: 31703321 PMCID: PMC6895921 URL: https://www.ncbi.nlm.nih.gov/pubmed/31703321
AbstractColorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Mouse models are a valuable resource for use throughout the development and testing of new therapeutic strategies for CRC. Tumorigenesis and response to therapy in humans and mouse models alike are influenced by the microbial communities that colonize the gut. Differences in the composition of the gut microbiota can confound experimental findings and reduce the replicability and translatability of the resulting data. Despite this, the contribution of resident microbiota to preclinical tumor models is often underappreciated. This review does the following: (1) summarizes evidence that the gut microbiota influence CRC disease phenotypes; (2) outlines factors that can influence the composition of the gut microbiota; and (3) provides strategies that can be incorporated into the experimental design, to account for the influence of the microbiota on intestinal phenotypes in mouse models of CRC. Through careful experimental design and documentation, mouse models can continue to rapidly advance efforts to prevent and treat colon cancer.
Notes2073-4425 Leystra, Alyssa A Clapper, Margie L P30 CA006927/CA/NCI NIH HHS/United States Journal Article Review Switzerland Genes (Basel). 2019 Nov 7;10(11). pii: genes10110900. doi: 10.3390/genes10110900.