FCCC LOGO Faculty Publications
Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
J Cell Biol. 2019 May 16;218(6) :1773-1775
Back to previous list
RIPK3 induces necroptosis by phosphorylating MLKL, which then induces plasma membrane rupture and necrotic cell death. In this issue, Sai et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810014) show that RIPK3-MLKL signaling in epithelial cells promotes Listeria clearance by directly suppressing cytosolic bacterial replication, without activating cell death.
1540-8140 Zhang, Ting Balachandran, Siddharth ORCID: http://orcid.org/0000-0003-2084-1803 Journal Article Comment United States J Cell Biol. 2019 May 16. pii: jcb.201905047. doi: 10.1083/jcb.201905047.