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Daher SS , Jin X , Patel J , Freundlich JS , Buttaro B , Andrade RB
Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens
Bioorg Med Chem Lett. 2019 Jun 1;29(11) :1386-1389
PMID: 30962084 PMCID: PMC6487207
AbstractNovel antibacterial drugs that treat multidrug resistant pathogens are in high demand. We have synthesized analogs of solithromycin using Cu(I)-mediated click chemistry. Evaluation of the analogs using Minimum Inhibitory Concentration (MIC) assays against resistant Staphylococcus aureus, Escherichia coli, and multidrug resistant pathogens Enterococcus faecium and Acinetobacter baumannii showed they possess potencies similar to those of solithromycin, thus demonstrating their potential as future therapeutics to combat the existential threat of multidrug resistant pathogens.
Notes1464-3405 Daher, Samer S Jin, Xiao Patel, Jimmy Freundlich, Joel S Buttaro, Bettina Andrade, Rodrigo B R01 GM126221/GM/NIGMS NIH HHS/United States T32 AI125185/AI/NIAID NIH HHS/United States U19 AI109713/AI/NIAID NIH HHS/United States Journal Article England Bioorg Med Chem Lett. 2019 Jun 1;29(11):1386-1389. doi: 10.1016/j.bmcl.2019.03.038. Epub 2019 Mar 26.