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Guindalini RS , Zheng YL , Abe H , Whitaker K , Yoshimatsu TF , Walsh T , Schacht D , Kulkarni K , Sheth D , Verp MS , Bradbury AR , Churpek J , Obeid E , Mueller J , Khramtsova G , Liu F , Raoul A , Cao HY , Romero IL , Hong S , Livingston R , Jaskowiak N , Wang XM , Debiasi M , Pritchard CC , King MC , Karczmar G , Newstead GM , Huo D , Olopade OI
Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers
Clin Cancer Res. 2019 Mar 15;25(6) :1786-1794
PMID: 30154229    PMCID: PMC6395536    URL: https://www.ncbi.nlm.nih.gov/pubmed/30154229
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Purpose: To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer. Experimental Design: We performed dynamic contrast-enhanced MRI every 6 months in conjunction with annual mammography (MG). Eligible participants had a cumulative lifetime breast cancer risk >= 20% and/or tested positive for a pathogenic mutation in a known breast cancer susceptibility gene. Results: Between 2004 and 2016, we prospectively enrolled 295 women, including 157 mutation carriers (75 BRCA1, 61 BRCA2); participants' mean age at entry was 43.3 years. Seventeen cancers were later diagnosed: 4 ductal carcinoma in situ (DCIS) and 13 early-stage invasive breast cancers. Fifteen cancers occurred in mutation carriers (11 BRCA1, 3 BRCA2, 1 CDH1). Median size of the invasive cancers was 0.61 cm. No patients had lymph node metastasis at time of diagnosis, and no interval invasive cancers occurred. The sensitivity of biannual MRI alone was 88.2% and annualMGplus biannual MRI was 94.1%. The cancer detection rate of biannual MRI alone was 0.7% per 100 screening episodes, which is similar to the cancer detection rate of 0.7% per 100 screening episodes for annual MG plus biannual MRI. The number of recalls and biopsies needed to detect one cancer by biannual MRI were 2.8 and 1.7 in BRCA1 carriers, 12.0 and 8.0 in BRCA2 carriers, and 11.7 and 5.0 in non-BRCA1/2 carriers, respectively. Conclusions: Biannual MRI performed well for early detection of invasive breast cancer in genomically stratified highrisk women. No benefit was associated with annual MG screening plus biannual MRI screening. See related commentary by Kuhl and Schrading, p. 1693
Guindalini, Rodrigo Santa Cruz Zheng, Yonglan Abe, Hiroyuki Whitaker, Kristen Yoshimatsu, Toshio F. Walsh, Tom Schacht, David Kulkarni, Kirti Sheth, Deepa Verp, Marion S. Bradbury, Angela R. Churpek, Jane Obeid, Elias Mueller, Jeffrey Khramtsova, Galina Liu, Fang Raoul, Akila Cao, Hongyuan Romero, Iris L. Hong, Susan Livingston, Robert Jaskowiak, Nora Wang, Xiaoming Debiasi, Marcio Pritchard, Colin C. King, Mary-Claire Karczmar, Gregory Newstead, Gillian M. Huo, Dezheng Olopade, Olufunmilayo I. 1557-3265 P50 CA125183/CA/NCI NIH HHS/ Clin Cancer Res. 2019 Mar 15;25(6):1786-1794. doi: 10.1158/1078-0432.CCR-18-0200. Epub 2018 Aug 28.