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Nabors LB , Portnow J , Ammirati M , Baehring J , Brem H , Butowski N , Fenstermaker RA , Forsyth P , Hattangadi-Gluth J , Holdhoff M , Howard S , Junck L , Kaley T , Kumthekar P , Loeffler JS , Moots PL , Mrugala MM , Nagpal S , Pandey M , Parney I , Peters K , Puduvalli VK , Ragsdale J 3rd , Rockhill J , Rogers L , Rusthoven C , Shonka N , Shrieve DC , Sills AK Jr , Swinnen LJ , Tsien C , Weiss S , Wen PY , Willmarth N , Bergman MA , Engh A
NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017
J Natl Compr Canc Netw. 2017 Nov;15(11) :1331-1345
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For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations of patients demonstrated the prognostic value of histologic phenotype, variability in outcomes within histologic groups limited the utility of this system. Nonetheless, histology was the only proven and widely accessible tool available at the time, thus it was used for clinical trial entry criteria, and therefore determined the recommended treatment options. Research to identify molecular changes that underlie glioma progression has led to the discovery of molecular features that have greater diagnostic and prognostic value than histology. Analyses of these molecular markers across populations from randomized clinical trials have shown that some of these markers are also predictive of response to specific types of treatment, which has prompted significant changes to the recommended treatment options for grade III (anaplastic) gliomas.
1540-1413 Nabors, Louis Burt Portnow, Jana Ammirati, Mario Baehring, Joachim Brem, Henry Butowski, Nicholas Fenstermaker, Robert A Forsyth, Peter Hattangadi-Gluth, Jona Holdhoff, Matthias Howard, Steven Junck, Larry Kaley, Thomas Kumthekar, Priya Loeffler, Jay S Moots, Paul L Mrugala, Maciej M Nagpal, Seema Pandey, Manjari Parney, Ian Peters, Katherine Puduvalli, Vinay K Ragsdale, John 3rd Rockhill, Jason Rogers, Lisa Rusthoven, Chad Shonka, Nicole Shrieve, Dennis C Sills, Allen K Jr Swinnen, Lode J Tsien, Christina Weiss, Stephanie Wen, Patrick Yung Willmarth, Nicole Bergman, Mary Anne Engh, Anita Journal Article United States J Natl Compr Canc Netw. 2017 Nov;15(11):1331-1345. doi: 10.6004/jnccn.2017.0166.