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Nizovtseva EV , Todolli S , Olson WK , Studitsky VM
Towards quantitative analysis of gene regulation by enhancers
Epigenomics. 2017 Sep;9(9) :1219-1231
PMID: 28799793 PMCID: PMC5585842 URL: https://www.ncbi.nlm.nih.gov/pubmed/28799793
AbstractEnhancers are regulatory DNA sequences that can activate transcription over large distances. Recent studies have revealed the widespread role of distant activation in eukaryotic gene regulation and in the development of various human diseases, including cancer. Here we review recent progress in the field, focusing on new experimental and computational approaches that quantify the role of chromatin structure and dynamics during enhancer-promoter interactions in vitro and in vivo.
Notes1750-192x Nizovtseva, Ekaterina V Todolli, Stefjord Olson, Wilma K Studitsky, Vasily M Journal Article England Epigenomics. 2017 Aug 11. doi: 10.2217/epi-2017-0061.