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Ragin C , Liu JC , Jones G , Shoyele O , Sowunmi B , Kennett R , Gibbs D , Blackman E , Esan M , Brandwein MS , Devarajan K , Bussu F , Chernock R , Chien CY , Cohen MA , El-Mofty S , Suzuki M , D'Souza G , Funchain P , Eng C , Gollin SM , Hong A , Jung YS , Kruger M , Lewis J , Morbini P , Landolfo S , Ritta M , Straetmans J , Szarka K , Tachezy R , Worden FP , Nelson D , Gathere S , Taioli E
Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients
Carcinogenesis. 2017 Feb;38(2) :218-229
PMID: 28025390    PMCID: PMC7191086    URL: https://www.ncbi.nlm.nih.gov/pubmed/28025390
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The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
Times Cited: 0 Ragin, Camille Liu, Jeffrey C. Jones, Gieira Shoyele, Olubunmi Sowunmi, Bukola Kennett, Rachel Gibbs, Denise Blackman, Elizabeth Esan, Michael Brandwein, Margaret S. Devarajan, Karthik Bussu, Francesco Chernock, Rebecca Chien, Chih-Yen Cohen, Marc A. El-Mofty, Samir Suzuki, Mikio D'Souza, Gypsyamber Funchain, Pauline Eng, Charis Gollin, Susanne M. Hong, Angela Jung, Yuh-S Krueger, Maximilian Lewis, James, Jr. Morbini, Patrizia Landolfo, Santo Ritta, Massimo Straetmans, Jos Szarka, Krisztina Tachezy, Ruth Worden, Francis P. Nelson, Deborah Gathere, Samuel Taioli, Emanuela 0 1460-2180