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CD4+ T cells require either B cells or CD8+ T cells to control spread and pathogenesis of a neurotropic infection
Virology. 2016 Dec;499 :196-202
PMID: 27677156 PMCID: PMC5102754 URL: https://www.ncbi.nlm.nih.gov/pubmed/27677156
AbstractImmunity within the brain, specifically to virus-infected neurons, must be controlled to prevent neuron loss and impairment, though the process by which this occurs remains unclear. Here, we use a mouse model of neuron-restricted measles virus infection, in which immunocompetent adults survive challenge, whereas T and B cell-deficient mice succumb. This model allowed us to more precisely define the contributions of CD4+ T cells, CD8+ T cells, and B cells in neuroprotection. Both B cell knockout mice and mice depleted of CD8+ T cells survive challenge and show no signs of illness, though are less able to control viral replication than immunocompetent mice. In contrast, depletion of CD4+ T cells results in disease and death in all infected mice, though the kinetics of illness are delayed compared to RAG knockout mice. Our data suggest a coordinated interplay of adaptive immune components, which collectively controls viral spread and limits neuropathogenesis.
NotesSolomos, Andreas C O'Regan, Kevin J Rall, Glenn F eng P30 CA006927/CA/NCI NIH HHS/ R01 NS040500/NS/NINDS NIH HHS/ 2016/09/28 06:00 Virology. 2016 Dec;499:196-202. doi: 10.1016/j.virol.2016.09.013. Epub 2016 Sep 24.