This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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The Relevance of Hereditary Cancer Risks to Precision Oncology: What Should Providers Consider When Conducting Tumor Genomic Profiling?
J Natl Compr Canc Netw. 2016 Jun;14(6) :795-806
PMID: 27283171 URL: http://www.ncbi.nlm.nih.gov/pubmed/27283171
AbstractThrough tumor genomic profiling (TGP), existing and novel treatments can be selected to better target the specific dysregulated molecular pathways that drive growth and spread of a patient's tumor. Although the primary purpose of TGP is to detect targetable somatic mutations for treatment, TGP may also uncover germline mutations with important implications for patients and family members. Oncology care providers should be aware of the hereditary cancer risks associated with genes commonly tested by TGP. Further, patients should be informed about the possible discovery of hereditary cancer risk information and the relevance of this information to their health and that of family members, and should have their preferences toward further evaluation of hereditary risk information that could be revealed by TGP documented in the medical record and followed.
NotesJain, Rishi Savage, Michelle J Forman, Andrea D Mukherji, Reetu Hall, Michael J Review United States J Natl Compr Canc Netw. 2016 Jun;14(6):795-806.