FCCC LOGO Faculty Publications
Gerasimova NS , Pestov NA , Kulaeva OI , Clark DJ , Studitsky VM
Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription
Transcription. 2016 May 26;7(3) :91-5
PMID: 27115204    PMCID: PMC4984681    URL: http://www.ncbi.nlm.nih.gov/pubmed/27115204
Back to previous list
RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.
Gerasimova, N S Pestov, N A Kulaeva, O I Clark, D J Studitsky, V M ENG R01 GM058650/GM/NIGMS NIH HHS/ 2016/04/27 06:00 Transcription. 2016 May 26;7(3):91-5. doi: 10.1080/21541264.2016.1182240. Epub 2016 Apr 26.