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Liu JC , Parajuli S , Blackman E , Gibbs D , Ellis A , Hull A , Beck JR , Giri V , Iherjirka P , Khurana JS , Ragin CR
High prevalence of discordant human papillomavirus and p16 oropharyngeal squamous cell carcinomas in an African American cohort
Head Neck. 2016 Apr;38 Suppl 1 :E867-72
PMID: 25962720    PMCID: PMC4643423    URL: http://www.ncbi.nlm.nih.gov/pubmed/25962720
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BACKGROUND: Most studies on human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) have been performed on white Americans. Our study examined the incidence of HPV in an African American oropharyngeal SCC cohort and its survival. METHODS: African American patients with oropharyngeal SCC in a combined tumor registry were identified. HPV16 testing was performed by polymerase chain reaction (PCR) from DNA extracted from tumor blocks. The p16 staining was performed using standard immunohistochemistry. RESULTS: Forty-four patients were identified for analysis. Seventy-three percent of the tumors were HPV-positive. Only 39% of the patients who were HPV-positive were also p16-positive. Survival between all 3 tumor types, patients who tested HPV-positive/p16, HPV-positive/p16-positive, and HPV-negative/p16-negative was significantly different (p = .03). HPV/p16 status was significant on univariate and multivariate analysis. CONCLUSION: HPV oropharyngeal SCC is strongly present in this African American cohort. Two thirds of the patients who were HPV-positive were p16-negative. Greater study is needed to explain the high p16 negativity among this HPV-positive oropharyngeal SCC African American cohort. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: E867-E872, 2016.
Liu, Jeffrey C Parajuli, Shobha Blackman, Elizabeth Gibbs, Denise Ellis, Ashley Hull, Anna Beck, J Robert Giri, Veda Iherjirka, Patrick Khurana, Jasvir S Ragin, Camille R eng P20 CA138017/CA/NCI NIH HHS/ P20 CA138068/CA/NCI NIH HHS/ P30 CA006927/CA/NCI NIH HHS/ 2015/05/13 06:00 Head Neck. 2016 Apr;38 Suppl 1:E867-72. doi: 10.1002/hed.24117. Epub 2015 Jul 18.