FCCC LOGO Faculty Publications
Francescone R , Hou V , Grivennikov SI
Cytokines, IBD, and Colitis-associated Cancer
Inflamm Bowel Dis. 2015 Feb;21(2) :409-18
PMID: 25563695    PMCID: PMC4481731    URL: https://www.ncbi.nlm.nih.gov/pubmed/25563695
Back to previous list
: Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal damage due to chronic inflammation. In addition, the perpetual state of inflammation predisposes individuals to the development of colitis-associated cancer. Because of the immense immune cell infiltration into colon, cytokines produced by immune cells are major players in the initiation and progression of IBD and colitis-associated cancer. In this review, we will explore the functions of many key cytokines and their roles in IBD and colitis-associated cancer, as well as their influences on the immune system and stromal cells. Finally, we will briefly discuss current therapies and current clinical trials targeting cytokines in IBD.
1536-4844 Francescone, Ralph Hou, Vivianty Grivennikov, Sergei I Journal Article United States Inflamm Bowel Dis. 2015 Feb;21(2):409-18. doi: 10.1097/MIB.0000000000000236.