This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Ragin C , Obikoya-Malomo M , Kim S , Chen Z , Flores-Obando R , Gibbs D , Koriyama C , Aguayo F , Koshiol J , Caporaso NE , Carpagnano GE , Ciotti M , Dosaka-Akita H , Fukayama M , Goto A , Spandidos DA , Gorgoulis V , Heideman DA , van Boerdonk RA , Hiroshima K , Iwakawa R , Kastrinakis NG , Kinoshita I , Akiba S , Landi MT , Eugene Liu H , Wang JL , Mehra R , Khuri FR , Lim WT , Owonikoko TK , Ramalingam S , Sarchianaki E , Syrjanen K , Tsao MS , Sykes J , Hee SW , Yokota J , Zaravinos A , Taioli E
HPV-associated lung cancers: an international pooled analysis
Carcinogenesis. 2014 Jun;35(6) :1267-75
PMID: 24523449 PMCID: PMC4043241 URL: https://www.ncbi.nlm.nih.gov/pubmed/24523449
AbstractHuman papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of cross-sectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship.
NotesRagin, Camille Obikoya-Malomo, Monisola Kim, Sungjin Chen, Zhengjia Flores-Obando, Rafael Gibbs, Denise Koriyama, Chihaya Aguayo, Francisco Koshiol, Jill Caporaso, Neil E Carpagnano, Giovanna E Ciotti, Marco Dosaka-Akita, Hirotoshi Fukayama, Masashi Goto, Akiteru Spandidos, Demetrios A Gorgoulis, Vassilis Heideman, Danielle A M van Boerdonk, Robert A A Hiroshima, Kenzo Iwakawa, Reika Kastrinakis, Nikolaos G Kinoshita, Ichiro Akiba, Suminori Landi, Maria T Eugene Liu, H Wang, Jinn-Li Mehra, Ranee Khuri, Fadlo R Lim, Wan-Teck Owonikoko, Taofeek K Ramalingam, Suresh Sarchianaki, Emmanuela Syrjanen, Kari Tsao, Ming-Sound Sykes, Jenna Hee, Siew Wan Yokota, Jun Zaravinos, Apostolos Taioli, Emanuela eng L30 CA130670/CA/NCI NIH HHS/ P30 CA006927/CA/NCI NIH HHS/ R03 CA141483/CA/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England Carcinogenesis. 2014 Jun;35(6):1267-75. doi: 10.1093/carcin/bgu038. Epub 2014 Feb 12.