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Rebbeck TR , Devesa SS , Chang BL , Bunker CH , Cheng I , Cooney K , Eeles R , Fernandez P , Giri VN , Gueye SM , Haiman CA , Henderson BE , Heyns CF , Hu JJ , Ingles SA , Isaacs W , Jalloh M , John EM , Kibel AS , Kidd LR , Layne P , Leach RJ , Neslund-Dudas C , Okobia MN , Ostrander EA , Park JY , Patrick AL , Phelan CM , Ragin C , Roberts RA , Rybicki BA , Stanford JL , Strom S , Thompson IM , Witte J , Xu J , Yeboah E , Hsing AW , Zeigler-Johnson CM
Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent
Prostate Cancer. 2013 ;2013 :560857
PMID: 23476788 PMCID: PMC3583061
AbstractProstate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.
NotesRebbeck, Timothy R Devesa, Susan S Chang, Bao-Li Bunker, Clareann H Cheng, Iona Cooney, Kathleen Eeles, Rosalind Fernandez, Pedro Giri, Veda N Gueye, Serigne M Haiman, Christopher A Henderson, Brian E Heyns, Chris F Hu, Jennifer J Ingles, Sue Ann Isaacs, William Jalloh, Mohamed John, Esther M Kibel, Adam S Kidd, Lacreis R Layne, Penelope Leach, Robin J Neslund-Dudas, Christine Okobia, Michael N Ostrander, Elaine A Park, Jong Y Patrick, Alan L Phelan, Catherine M Ragin, Camille Roberts, Robin A Rybicki, Benjamin A Stanford, Janet L Strom, Sara Thompson, Ian M Witte, John Xu, Jianfeng Yeboah, Edward Hsing, Ann W Zeigler-Johnson, Charnita M Egypt Prostate cancer Prostate Cancer. 2013;2013:560857. doi: 10.1155/2013/560857. Epub 2013 Feb 13.