FCCC LOGO Faculty Publications
Kirchhoff T , Gaudet MM , Antoniou AC , McGuffog L , Humphreys MK , Dunning AM , Bojesen SE , Nordestgaard BG , Flyger H , Kang D , Yoo KY , Noh DY , Ahn SH , Dork T , Schurmann P , Karstens JH , Hillemanns P , Couch FJ , Olson J , Vachon C , Wang X , Cox A , Brock I , Elliott G , Reed MW , Burwinkel B , Meindl A , Brauch H , Hamann U , Ko YD , Genica Network , Broeks A , Schmidt MK , Van 't Veer LJ , Braaf LM , Johnson N , Fletcher O , Gibson L , Peto J , Turnbull C , Seal S , Renwick A , Rahman N , Wu PE , Yu JC , Hsiung CN , Shen CY , Southey MC , Hopper JL , Hammet F , Van Dorpe T , Dieudonne AS , Hatse S , Lambrechts D , Andrulis IL , Bogdanova N , Antonenkova N , Rogov JI , Prokofieva D , Bermisheva M , Khusnutdinova E , van Asperen CJ , Tollenaar RA , Hooning MJ , Devilee P , Margolin S , Lindblom A , Milne RL , Arias JI , Zamora MP , Benitez J , Severi G , Baglietto L , Giles GG , kConFab , Aocs Study Group , Spurdle AB , Beesley J , Chen X , Holland H , Healey S , Wang-Gohrke S , Chang-Claude J , Mannermaa A , Kosma VM , Kauppinen J , Kataja V , Agnarsson BA , Caligo MA , Godwin AK , Nevanlinna H , Heikkinen T , Fredericksen Z , Lindor N , Nathanson KL , Domchek SM , Swe Brca , Loman N , Karlsson P , Stenmark Askmalm M , Melin B , von Wachenfeldt A , Hebon , Hogervorst FB , Verheus M , Rookus MA , Seynaeve C , Oldenburg RA , Ligtenberg MJ , Ausems MG , Aalfs CM , Gille HJ , Wijnen JT , Gomez Garcia EB , Embrace , Peock S , Cook M , Oliver CT , Frost D , Luccarini C , Pichert G , Davidson R , Chu C , Eccles D , Ong KR , Cook J , Douglas F , Hodgson S , Evans DG , Eeles R , Gold B , Pharoah PD , Offit K , Chenevix-Trench G , Easton DF , Bcac/Cimba
Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
PLoS One. 2012 Jun;7(6) :e35706
PMID: 22768030    PMCID: PMC3387216    URL: https://www.ncbi.nlm.nih.gov/pubmed/22768030
Back to previous list
Abstract
Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
Notes
Kirchhoff, Tomas Gaudet, Mia M Antoniou, Antonis C McGuffog, Lesley Humphreys, Manjeet K Dunning, Alison M Bojesen, Stig E Nordestgaard, Borge G Flyger, Henrik Kang, Daehee Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Dork, Thilo Schurmann, Peter Karstens, Johann H Hillemanns, Peter Couch, Fergus J Olson, Janet Vachon, Celine Wang, Xianshu Cox, Angela Brock, Ian Elliott, Graeme Reed, Malcolm W R Burwinkel, Barbara Meindl, Alfons Brauch, Hiltrud Hamann, Ute Ko, Yon-Dschun Broeks, Annegien Schmidt, Marjanka K Van 't Veer, Laura J Braaf, Linde M Johnson, Nichola Fletcher, Olivia Gibson, Lorna Peto, Julian Turnbull, Clare Seal, Sheila Renwick, Anthony Rahman, Nazneen Wu, Pei-Ei Yu, Jyh-Cherng Hsiung, Chia-Ni Shen, Chen-Yang Southey, Melissa C Hopper, John L Hammet, Fleur Van Dorpe, Thijs Dieudonne, Anne-Sophie Hatse, Sigrid Lambrechts, Diether Andrulis, Irene L Bogdanova, Natalia Antonenkova, Natalia Rogov, Juri I Prokofieva, Daria Bermisheva, Marina Khusnutdinova, Elza van Asperen, Christi J Tollenaar, Robert A E M Hooning, Maartje J Devilee, Peter Margolin, Sara Lindblom, Annika Milne, Roger L Arias, Jose Ignacio Zamora, M Pilar Benitez, Javier Severi, Gianluca Baglietto, Laura Giles, Graham G Spurdle, Amanda B Beesley, Jonathan Chen, Xiaoqing Holland, Helene Healey, Sue Wang-Gohrke, Shan Chang-Claude, Jenny Mannermaa, Arto Kosma, Veli-Matti Kauppinen, Jaana Kataja, Vesa Agnarsson, Bjarni A Caligo, Maria A Godwin, Andrew K Nevanlinna, Heli Heikkinen, Tuomas Fredericksen, Zachary Lindor, Noralane Nathanson, Katherine L Domchek, Susan M Loman, Niklas Karlsson, Per Stenmark Askmalm, Marie Melin, Beatrice von Wachenfeldt, Anna Hogervorst, Frans B L Verheus, Martijn Rookus, Matti A Seynaeve, Caroline Oldenburg, Rogier A Ligtenberg, Marjolijn J Ausems, Margreet G E M Aalfs, Cora M Gille, Hans J P Wijnen, Juul T Gomez Garcia, Encarna B Peock, Susan Cook, Margaret Oliver, Clare T Frost, Debra Luccarini, Craig Pichert, Gabriella Davidson, Rosemarie Chu, Carol Eccles, Diana Ong, Kai-Ren Cook, Jackie Douglas, Fiona Hodgson, Shirley Evans, D Gareth Eeles, Rosalind Gold, Bert Pharoah, Paul D P Offit, Kenneth Chenevix-Trench, Georgia Easton, Douglas F eng 11174/Cancer Research UK/United Kingdom 11022/Cancer Research UK/United Kingdom G0700491/Medical Research Council/United Kingdom 10118/Cancer Research UK/United Kingdom 10124/Cancer Research UK/United Kingdom PLoS One. 2012;7(6):e35706. doi: 10.1371/journal.pone.0035706. Epub 2012 Jun 29.