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Velvadapu V , McDonnell ME , Jaffe EK , Reitz AB
Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one
Tetrahedron Lett. 2012 Jun 20;53(25) :3144-3146
PMID: 22822274    PMCID: PMC3398704    URL: https://www.ncbi.nlm.nih.gov/pubmed/22822274
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3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (Mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods.
Velvadapu, Venkata McDonnell, Mark E Jaffe, Eileen K Reitz, Allen B eng England Tetrahedron Lett. 2012 Jun 20;53(25):3144-3146. doi: 10.1016/j.tetlet.2012.04.044.