FCCC Faculty Publications

Bilusic M, Girardi D, Zhou Y, Jung KS, Pei JM, Slifker M, Chen QR, Meerzaman D, Alpaugh K, Young D, Flieder D, Gray P, Plimack E. Molecular Profiling of Exceptional Responders to Cancer Therapy. Oncologist. .

Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. Cancer Discov. 2021 Feb;11(2) :446-479. PMC ID:PMC7858242.

Ye S, Sharipova D, Kozinova M, Klug L, D’Souza J, Belinsky MG, Johnson KJ, Einarson MB, Devarajan K, Zhou Y, Litwin S, Heinrich MC, DeMatteo R, von Mehren M, Duncan JS, Rink L. Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment. JCI Insight. 2021 Jan 25;6(2) . PMC ID:PMC7934848.

Tian Y, Meng L, Wang Y, Li B, Yu H, Zhou Y, Bui T, Li A, Abraham C, Zhang Y, Wang J, Zhao C, Mineishi S, Gallucci S, Porter D, Hexner E, Zheng H, Zhang Y, Hu S, Zhang Y. Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction. J Clin Invest. 2021 Jan 4;131(1) . PMC ID:PMC7773406.

Bilusic M, Girardi D, Zhou Y, Jung K, Pei J, Slifker M, Chen Q, Meerzaman D, Alpaugh K, Young D, Flieder D, Gray P, Plimack E. Molecular Profiling of Exceptional Responders to Cancer Therapy. Oncologist. 2020 Nov 19 .

Huang G, Garikipati VNS, Zhou Y, Benedict C, Houser SR, Koch WJ, Kishore R. Identification and Comparison of Hyperglycemia-Induced Extracellular Vesicle Transcriptome in Different Mouse Stem Cells. Cells. 2020 Sep 15;9(9) . PMC ID:PMC7564160.

Cheng J, Zhao Q, Zhou Y, Tang L, Sheraz M, Chang J, Guo JT. Interferon Alpha Induces Multiple Cellular Proteins That Coordinately Suppress Hepadnaviral Covalently Closed Circular DNA Transcription. J Virol. 2020 Aug 17;94(17) . PMC ID:PMC7431811.

Wei W, Lin Y, Song Z, Xiao W, Chen L, Yin J, Zhou Y, Barta SK, Petrus M, Waldmann TA, Yang Y. A20 and RBX1 regulate brentuximab vedotin sensitivity in Hodgkin Lymphoma models. Clin Cancer Res. 2020 Aug 1;26(15) :4093-4106. PMC ID:PMC7549381.

Aguilar SV, Aguilar O, Allan R, Amir ED, Angeli V, Artyomov MN, Asinovski N, Astarita J, Austen KF, Bajpai G, Barrett N, Baysoy A, Benoist C, Bellemare-Pelletier A, Berg B, Best A, Bezman N, Blair D, Blander JM, Bogunovic M, Brennan P, Brenner M, Brown B, Buechler M, Buenrostro J, Casanova MA, Choi K, Chow A, Chudnovskiy A, Cipoletta D, Cohen N, Collins JJ, Colonna M, Cook A, Costello J, Cremasco V, Crowl T, Crozat K, Cruse R, D'Angelo J, Dalod M, Davis S, Demiralp C, Deng TD, Desai JV, Desland F, Dhainaut M, Ding JR, Doedens A, Dominguez C, Doran G, Dress R, Dustin M, Dwyer D, Dzhagalov I, Elpek K, Ergun A, Ericson J, Esomonu E, Fairfax K, Fletcher A, Frascoli M, Fuchs A, Gainullina A, Gal-Oz S, Gallagher M, Gautier E, Gazit R, Gibbings S, Giraud M, Ginhoux F, Goldrath A, Gotthardt D, Gray D, Greter M, Grieshaber-Bouyer R, Guilliams M, Haidermota S, Hardy R, Hashimoto D, Helft J, Hendricks D, Heng T, Hill J, Hyatt G, Idoyaga J, Jakubzick C, Jarjoura J, Jepson D, Jia BS, Jianu R, Johanson T, Jordan S, Jojic V, Jordan S, Kamimura Y, Kana V, Kang JS, Kapoor V, Kenigsberg E, Kent A, Kim C, Kim E, Kim F, Kim J, Kim K, Kiner E, Knell J, Koller D, Kozinn L, Krchma K, Kreslavsky T, Kronenberg M, Kwan WH, Laidlaw D, Lam V, Lanier L, Laplace C, Lareau C, Lavin Y, Lavine KJ, Leader A, Leboeuf M, Lee JC, Lee JS, Li B, Li H, Li YS, Lionakis MS, Luche H, Lynch L, Magen A, Maier B, Malhotra D, Malhotra N, Malissen M, Maslova A, Mathis D, McFarland A, Merad M, Meunier E, Miller J, Milner J, Mingueneau M, Min-Oo G, Monach P, Moodley D, Mortha A, Morvan M, Mostafavi S, Muller S, Muus C, Nabekura T, Rao TN, Narang V, Narayan K, Ner-Gaon H, Nguyen Q, Nigrovic PA, Novakovsky G, Nutt S, Omilusik K, Ortiz-Lopez A, Paidassi H, Paik H, Painter M, Paynich M, Peng VC, Potempa M, Pradhan R, Price J, Qi YL, Qi YQ, Quon S, Ramirez R, Ramanan D, Randolph G, Regev A, Rhoads A, Robinette M, Rose S, Rossi D, Rothamel K, Sachidanandam R, Sathe P, Scott C, Seddu K, See P, Sergushichev A, Shaw L, Shay T, Shemesh A, Shinton S, Shyer J, Sieweke M, Smillie C, Spel L, Spidale N, Stifano G, Subramanian A, Sun JS, Sylvia K, Tellier J, This S, Tomasello E, Todorov H, Turley S, Vijaykumar B, Wagers A, Wakamatsu E, Wang CD, Wang PTL, Wroblewska A, Wu J, Yang ED, Yang L, Yim A, Yng LS, Yoshida H, Yu BF, Zhou Y, Zhu YN, Ziemkiewicz C, Immunological Genome Project. ImmGen at 15. Nature Immunology. 2020 Jul;21(7) :700-703.

Deneka AY, Einarson MB, Bennett J, Nikonova AS, Elmekawy M, Zhou Y, Lee JW, Burtness BA, Golemis EA. Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer. Cancers (Basel). 2020 Jan 28;12(2) . PMC ID:PMC7072436.

Fu H, Sun Y, Shao Y, Saredy J, Cueto R, Liu L, Drummer Cth, Johnson C, Xu K, Lu Y, Li X, Meng S, Xue ER, Tan J, Jhala NC, Yu D, Zhou Y, Bayless KJ, Yu J, Rogers TJ, Hu W, Snyder NW, Sun J, Qin X, Jiang X, Wang H, Yang X. Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis. Front Immunol. 2020 ;11 :595813. PMC ID:PMC7591706.

Clark WT, Kasak L, Bakolitsa C, Hu Z, Andreoletti G, Babbi G, Bromberg Y, Casadio R, Dunbrack R, Folkman L, Ford CT, Jones D, Katsonis P, Kundu K, Lichtarge O, Martelli PL, Mooney SD, Nodzak C, Pal LR, Radivojac P, Savojardo C, Shi X, Zhou Y, Uppal A, Xu Q, Yin Y, Pejaver V, Wang M, Wei L, Moult J, Yu GK, Brenner SE, LeBowitz JH. Assessment of predicted enzymatic activity of alpha-N-acetylglucosaminidase (NAGLU) variants of unknown significance for CAGI 2016. Hum Mutat. 2019 Sep;40(9) :1519-1529.

Zhang X, Liu B, Tang L, Su Q, Hwang N, Sehgal M, Cheng J, Ma J, Zhang X, Tan Y, Zhou Y, Duan Z, DeFilippis VR, Viswanathan U, Kulp J, Du Y, Guo JT, Chang J. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist. ACS Infect Dis. 2019 Jul 12;5(7) :1139-1149. PMC ID:PMC7082846.

Nicolas E, Demidova EV, Iqbal W, Serebriiskii IG, Vlasenkova R, Ghatalia P, Zhou Y, Rainey K, Forman AF, Dunbrack RL Jr, Golemis EA, Hall MJ, Daly MB, Arora S. Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma. Mol Genet Genomic Med. 2019 Mar;7(3) :e556. PMC ID:PMC6418363.

Li A, Sun Y, Drummer Cth, Lu Y, Yu D, Zhou Y, Li X, Pearson SJ, Johnson C, Yu C, Yang WY, Mastascusa K, Jiang X, Sun J, Rogers T, Hu W, Wang H, Yang X. Increasing Upstream Chromatin Long-Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells. Front Physiol. 2019 ;10 :433. PMC ID:PMC6482593.

Wu S, Luo Y, Viswanathan U, Kulp J, Cheng J, Hu Z, Xu Q, Zhou Y, Gong GZ, Chang J, Li Y, Guo JT. CpAMs induce assembly of HBV capsids with altered electrophoresis mobility: Implications for mechanism of inhibiting pgRNA packaging. Antiviral Res. 2018 Nov;159 :1-12.

Gabbasov R, Xiao F, Howe CG, Bickel LE, O'Brien SW, Benrubi D, Do TV, Zhou Y, Nicolas E, Cai KQ, Litwin S, Seo S, Golemis EA, Connolly DC. NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice. Oncogene. 2018 Aug;37(35) :4854-4870. PMC ID:PMC6119087.

Chang WL, Jackson C, Riel S, Cooper HS, Devarajan K, Hensley HH, Zhou Y, Vanderveer LA, Nguyen MT, Clapper ML. Differential preventive activity of sulindac and atorvastatin in Apc(+/Min-FCCC)mice with or without colorectal adenomas. Gut. 2018 Jul;67(7) :1290-1298. PMC ID:PMC6031273.

Lulla AR, Slifker MJ, Zhou Y, Lev A, Einarson MB, Dicker DT, El-Deiry WS. miR-6883 family miRNAs target CDK4/6 to induce G1 phase cell cycle arrest in colon cancer cells. Cancer Res. 2017 Dec 15;77(24) :6902-6913.

Cho JH, Patel B, Bonala S, Manne S, Zhou Y, Vadrevu SK, Patel J, Peronaci M, Ghouse S, Henske EP, Roegiers F, Giannikou K, Kwiatkowski DJ, Mansouri H, Markiewski MM, White B, Karbowniczek M. Notch transactivates Rheb to maintain the multipotency of TSC-null cells. Nat Commun. 2017 Nov 29;8(1) :1848. PMC ID:PMC5705704.

Liu B, Tang L, Zhang X, Ma J, Sehgal M, Cheng J, Zhang X, Zhou Y, Du Y, Kulp J, Guo JT, Chang J. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists. Antiviral Res. 2017 Nov;147 :37-46. PMC ID:PMC5789800.

Hayakawa K, Formica AM, Zhou Y, Ichikawa D, Asano M, Li YS, Shinton SA, Brill-Dashoff J, Nunez G, Hardy RR. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. J Exp Med. 2017 Oct 02;214(10) :3067-3083. PMC ID:PMC5626402.

Lev A, Lulla AR, Wagner J, Ralff MD, Kiehl JB, Zhou Y, Benes CH, Prabhu VV, Oster W, Astsaturov I, Dicker DT, El-Deiry WS. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. Oncotarget. 2017 Oct;8(47) :81776-81793. PMC ID:PMC5669847.

Ursu O, Gosline SJC, Beeharry N, Fink L, Bhattacharjee V, Huang SC, Zhou Y, Yen T, Fraenkel E. Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens. PLoS One. 2017 Oct;12(10) :e0185650. PMC ID:PMC5638242.

Belinsky MG, Cai KQ, Zhou Y, Luo B, Pei J, Rink L, von Mehren M. Succinate dehydrogenase deficiency in a PDGFRA mutated GIST. BMC Cancer. 2017 Aug 02;17(1) :512. PMC ID:PMC5541693.

Jiang P, Li Y, Poleshko A, Medvedeva V, Baulina N, Zhang Y, Zhou Y, Slater CM, Pellegrin T, Wasserman J, Lindy M, Efimov A, Daly M, Katz RA, Chen X. The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network. EBioMedicine. 2017 Jun 27;22 :28-43. PMC ID:PMC5552109.

Jiang Z, Slater CM, Zhou Y, Devarajan K, Ruth KJ, Li Y, Cai KQ, Daly M, Chen X. LincIN, a novel NF90-binding long non-coding RNA, is overexpressed in advanced breast tumors and involved in metastasis. Breast Cancer Res. 2017 May 30;19(1) :62. PMC ID:PMC5450112.

Carraro M, Minervini G, Giollo M, Bromberg Y, Capriotti E, Casadio R, Dunbrack R, Elefanti L, Fariselli P, Ferrari C, Gough J, Katsonis P, Leonardi E, Lichtarge O, Menin C, Martelli PL, Niroula A, Pal LR, Repo S, Scaini MC, Vihinen M, Wei Q, Xu Q, Yang Y, Yin Y, Zaucha J, Zhao H, Zhou Y, Brenner SE, Moult J, Tosatto SCE. Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Hum Mutat. 2017 Apr 25;38(9) :1042-1050. PMC ID:PMC5561474.

Zook P, Pathak HB, Belinsky MG, Gersz L, Devarajan K, Zhou Y, Godwin AK, von Mehren M, Rink L. Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor. Clin Cancer Res. 2017 Jan 01;23(1) :171-180. PMC ID:PMC5203981.

Beglyarova N, Banina E, Zhou Y, Mukhamadeeva R, Andrianov G, Bobrov E, Lysenko E, Skobeleva N, Gabitova L, Restifo D, Pressman M, Serebriiskii IG, Hoffman JP, Paz K, Behrens D, Khazak V, Jablonski SA, Weiner LM, Golemis EA, Astsaturov I. Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer. Clin Cancer Res. 2016 Dec 15;22(24) :6153-6163. PMC ID:PMC5161635.

Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC, Hardy RR. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression. J Exp Med. 2016 Dec;213(13) :3007-3024. PMC ID:PMC5154941.

Mason WS, Gill US, Litwin S, Zhou Y, Peri S, Pop O, Hong ML, Naik S, Quaglia A, Bertoletti A, Kennedy PT. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology. 2016 Jul 21;151(5) :986-998 e4.

Beck TN, Korobeynikov VA, Kudinov AE, Georgopoulos R, Solanki NR, Andrews-Hoke M, Kistner TM, Pepin D, Donahoe PK, Nicolas E, Einarson MB, Zhou Y, Boumber Y, Proia DA, Serebriiskii IG, Golemis EA. Anti-Mullerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer. Cell Rep. 2016 Jul 19;16(3) :657-71. PMC ID:PMC4956518.

Mohsin S, Troupes CD, Starosta T, Sharp TE, Agra EJ, Smith SC, Duran JM, Zalavadia N, Zhou Y, Kubo H, Berretta RM, Houser SR. Unique Features of Cortical Bone Stem Cells Associated with Repair of the Injured Heart. Circ Res. 2015 Dec 4;117(12) :1024-33.

Li YS, Zhou Y, Tang L, Shinton SA, Hayakawa K, Hardy RR. A developmental switch between fetal and adult B lymphopoiesis. Ann N Y Acad Sci. 2015 Dec;1362(1) :8-15.

Plimack ER, Dunbrack RL, Brennan TA, Andrake MD, Zhou Y, Serebriiskii IG, Slifker M, Alpaugh K, Dulaimi E, Palma N, Hoffman-Censits J, Bilusic M, Wong YN, Kutikov A, Viterbo R, Greenberg RE, Chen DY, Lallas CD, Trabulsi EJ, Yelensky R, McConkey DJ, Miller VA, Golemis EA, Ross EA. Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer. Eur Urol. 2015 Dec;68(6) :959-67. PMC ID:PMC4764095.

Nicolas E, Arora S, Zhou Y, Serebriiskii IG, Andrake MD, Handorf ED, Bodian DL, Vockley JG, Dunbrack RL, Ross EA, Egleston BL, Hall MJ, Golemis EA, Giri VN, Daly MB. Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget. 2015 Nov 24;6(37) :39614-33. PMC ID:PMC4741850.

Traynham CJ, Cannavo A, Zhou Y, Vouga A, Woodall BP, Hullmann JE, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ. Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. Circ Res. 2015 Oct 29;117(12) :1001-12. PMC ID:PMC4825669.

Arora S, Yan H, Cho I, Fan HY, Luo B, Gai X, Bodian DL, Vockley JG, Zhou Y, Handorf E, Egleston BL, Andrake M, Nicolas E, Serebriiskii I, Yen TJ, Hall MJ, Golemis EA, Enders GH. Genetic Variants That Presdispose to DNA Double-strand Breaks in Lymphocytes from a Subset of Patients With Familial Colorectal Carcinomas. Gastroenterology. 2015 Sep 4;149(7) :1872-1883 e9.

Ramirez UD, Nikonova AS, Liu H, Pecherskaya A, Lawrence SH, Serebriiskii IG, Zhou Y, Robinson MK, Einarson MB, Golemis EA, Jaffe EK. Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC Cancer. 2015 May 28;15 :436. PMC ID:PMC4451962.

Zhou Y, Li YS, Bandi SR, Tang L, Shinton SA, Hayakawa K, Hardy RR. Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a. J Exp Med. 2015 Apr 6;212(4) :569-80. PMC ID:PMC4387290.

Gritsina G, Xiao F, O'Brien SW, Gabbasov R, Maglaty MA, Xu RH, Thapa RJ, Zhou Y, Nicolas E, Litwin S, Balachandran S, Sigal LJ, Huszar D, Connolly DC. Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. Mol Cancer Ther. 2015 Apr;14(4) :1035-47. PMC ID:PMC4394029.

Kim B, Wang S, Lee JM, Jeong Y, Ahn T, Son DS, Park HW, Yoo HS, Song YJ, Lee E, Oh YM, Lee SB, Choi J, Murray JC, Zhou Y, Song PH, Kim KA, Weiner LM. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene. 2015 Feb 26;34(9) :1083-93.

Kung CP, Khaku S, Jennis M, Zhou Y, Murphy ME. Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes. Mol Cancer Res. 2015 Feb;13(2) :250-62.

Pathak HB, Zhou Y, Sethi G, Hirst J, Schilder RJ, Golemis EA, Godwin AK. A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer. PLoS One. 2015 ;10(12) :e0144126. PMC ID:PMC4670180.

Kwon Y, Smith BD, Zhou Y, Kaufman MD, Godwin AK. Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment. Oncogene. 2015 Jan;34(2) :144-153. PMC ID:PMC4067476.

Domanitskaya N, Wangari-Talbot J, Jacobs J, Peiffer E, Mahdaviyeh Y, Paulose C, Malofeeva E, Foster K, Cai KQ, Zhou Y, Egleston B, Hopper-Borge E. Abcc10 status affects mammary tumour growth, metastasis, and docetaxel treatment response. Br J Cancer. 2014 Aug 12;111(4) :696-707. PMC ID:PMC4134493.

Perkins J, Boland P, Cohen SJ, Olszanski AJ, Zhou Y, Engstrom P, Astsaturov I. Successful Imatinib Therapy for Neuroendocrine Carcinoma With Activating KIT Mutation: A Case Study. J Natl Compr Canc Netw. 2014 Jun;12(6) :847-52. PMC ID:PMC4112647.

Guo F, Zhao X, Gill T, Zhou Y, Campagna M, Wang L, Liu F, Zhang P, DiPaolo L, Du Y, Xu X, Jiang D, Wei L, Cuconati A, Block TM, Guo JT, Chang J. An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses. Antiviral Res. 2014 Apr 30;107 :56-65.

Gowrishankar B, Ibragimova I, Zhou Y, Slifker MJ, Devarajan K, Al-Saleem T, Uzzo RG, Cairns P. MicroRNA expression signatures of stage, grade, and progression in clear cell RCC. Cancer Biol Ther. 2014 Mar 1;15(3) :329-41. PMC ID:PMC3974834.

Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL. Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nat Commun. 2014 Feb 4;5 :3183. PMC ID:PMC 3995141.

Bhattacharjee V, Zhou Y, Yen T. A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell Cycle. 2014 ;13(24) :3839-56.

Brusilovsky M, Cordoba M, Rosental B, Hershkovitz O, Andrake MD, Pecherskaya A, Einarson MB, Zhou Y, Braiman A, Campbell KS, Porgador A. Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses. J Immunol. 2013 Nov 15;191(10) :5256-67. PMC ID:PMC3836631.

Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan;3(1) :96-111. PMC ID:PMC3546138.

Rink L, Ochs MF, Zhou Y, von Mehren M, Godwin AK. ZNF-Mediated Resistance to Imatinib Mesylate in Gastrointestinal Stromal Tumor. PLoS One. 2013 ;8(1) :e54477. PMC ID:PMC3556080.

Gao C, Devarajan K, Zhou Y, Slater CM, Daly MB, Chen X. Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome. BMC Genomics. 2012 Oct 30;13(1) :570. PMC ID:PMCID3532379.

Sethi G, Pathak HB, Zhang H, Zhou Y, Einarson MB, Vathipadiekal V, Gunewardena S, Birrer MJ, Godwin AK. An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer. PLoS One. 2012 Oct;7(10) :e47086.

Fernandez SV, Huang Y, Snider KE, Zhou Y, Pogash TJ, Russo J. Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1) :369-77. PMC ID:PMC3466112 .

Zhou Y, Goenaga AL, Harms BD, Zou H, Lou JL, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD. Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies. Molecular Cancer Therapeutics. 2012 Jul;11(7) :1467-1476.

Jiang Z, Zhou Y, Devarajan K, Slater CM, Daly MB, Chen X. Identifying putative breast cancer-associated long intergenic non-coding RNA loci by high density SNP array analysis. Front Genet. 2012 ;3 :299. PMC ID:PMC3528021.

Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J, Boorjian SA. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. Bju International. 2011 Jul;108(2B) :E84-E90. PMC ID:PMC3116980.

Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT. cpsf1 is required for definitive HSC survival in zebrafish. Blood. 2011 Apr;117(15) :3996-4007.

Frank AK, Leu JIJ, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME. The Codon 72 Polymorphism of p53 Regulates Interaction with NF-kappa B and Transactivation of Genes Involved in Immunity and Inflammation. Molecular and Cellular Biology. 2011 Mar;31(6) :1201-1213. PMC ID:PMC3067895.

Bagnyukova T, Serebriiskii IG, Zhou Y, Hopper-Borge EA, Golemis EA, Astsaturov I. Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?. Cancer Biol Ther. 2010 Nov 2;10(9) :839-853.

Devarajan K, Zhou Y, Chachra N, Ebrahimi N. A supervised approach for predicting patient survival with gene expression data. Proc IEEE Int Symp Bioinformatics Bioeng. 2010 ;2010(5521718) :26-31. PMC ID:PMC2941901.

Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila Pa). 2010 Jan;3(1) :48-61. PMC ID:PMC2804937.

Astsaturov I, Ratushny V, Sukhanova A, Einarson MB, Bagnyukova T, Zhou Y, Devarajan K, Silverman JS, Tikhmyanova N, Skobeleva N, Pecherskaya A, Nasto RE, Sharma C, Jablonski SA, Serebriiskii IG, Weiner LM, Golemis EA. Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Sci Signal. 2010 ;3(140) :ra67. PMC ID:PMC2950064.

Zhou Y, Hopper-Borge E, Shen T, Huang XC, Shi Z, Kuang YH, Furukawa T, Akiyama S, Peng XX, Ashby CR, Chen X, Kruh GD, Chen ZS. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochemical Pharmacology. 2009 Mar;77(6) :993-1001.

Amin RH, Cado D, Nolla H, Huang D, Shinton SA, Zhou Y, Hardy RR, Schlissel MS. Biallelic, ubiquitous transcription from the distal germline Ig kappa locus promoter during B cell development. Proceedings of the National Academy of Sciences of the United States of America. 2009 Jan;106(2) :522-527. PMC ID:PMC2626736.

Peng XX, Shi Z, Damaraju VL, Huang XC, Kruh GD, Wu HC, Zhou Y, Tiwari A, Fu L, Cass CE, Chen ZS. Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine. Leukemia Research. 2008 May;32(5) :799-809.

Zhou Y, Daryl C, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD. Impact of single-chain fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells. Journal of Molecular Biology. 2007 Aug;371(4) :934-947.

Rumfelt LL, Zhou Y, Rowley BM, Shinton SA, Hardy RR. Lineage specification and plasticity in CD19(-) early B cell precursors. JOURNAL OF EXPERIMENTAL MEDICINE. 2006 Mar;203(3) :675-687.

Zhou Y (72 publications)