|
|---|
|
Ferez M,
Knudson CJ,
Lev A,
Wong EB,
Alves-Peixoto P,
Tang L,
Stotesbury C,
Sigal LJ. Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing.
J Exp Med. 2021 May 3;218(5)
. |
|
Tian X,
Ahsan N,
Lulla A,
Lev A,
Abbosh P,
Dicker DT,
Zhang S,
El-Deiry WS. P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9.
Neoplasia. 2021 Feb 11;23(3)
:304-325. PMC ID:PMC7890376. |
|
Ralff MD,
Jhaveri A,
Ray JE,
Zhou L,
Lev A,
Campbell KS,
Dicker DT,
Ross EA,
El-Deiry WS. TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic.
Oncotarget. 2020 Oct 20;11(42)
:3753-3769. PMC ID:PMC7584235. |
|
Wong E,
Xu RH,
Rubio D,
Lev A,
Stotesbury C,
Fang M,
Sigal LJ. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node.
Cell Reports. 2018 Jul 3;24(1)
:142-154. PMC ID:PMC6232077. |
|
Lev A,
Lulla AR,
Ross BC,
Ralff MD,
Makhov PB,
Dicker DT,
El-Deiry WS. ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer.
Mol Cancer Res. 2018 Mar 27;16(5)
:754-766. PMC ID:PMC5932216. |
|
Lulla AR,
Slifker MJ,
Zhou Y,
Lev A,
Einarson MB,
Dicker DT,
El-Deiry WS. miR-6883 family miRNAs target CDK4/6 to induce G1 phase cell cycle arrest in colon cancer cells.
Cancer Res. 2017 Dec 15;77(24)
:6902-6913. |
|
Somech R,
Lev A,
Lee YN,
Simon AJ,
Barel O,
Schiby G,
Avivi C,
Barshack I,
Rhodes M,
Yin J,
Wang M,
Yang Y,
Rhodes J,
Marcus N,
Garty BZ,
Stein J,
Amariglio N,
Rechavi G,
Wiest DL,
Zhang Y. Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.
J Immunol. 2017 Nov 10;199(12)
:4036-4045. PMC ID:PMC5726601. |
|
Wagner J,
Kline CL,
Ralff MD,
Lev A,
Lulla A,
Zhou L,
Olson GL,
Nallaganchu BR,
Benes CH,
Allen JE,
Prabhu VV,
Stogniew M,
Oster W,
El-Deiry WS. Preclinical evaluation of the imipridone family, analogues of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.
Cell Cycle. 2017 Oct 02;16(19)
:1790-1799. PMC ID:PMC5628644. |
|
Lev A,
Lulla AR,
Wagner J,
Ralff MD,
Kiehl JB,
Zhou Y,
Benes CH,
Prabhu VV,
Oster W,
Astsaturov I,
Dicker DT,
El-Deiry WS. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.
Oncotarget. 2017 Oct;8(47)
:81776-81793. PMC ID:PMC5669847. |
|
Lev A,
Deihimi S,
Shagisultanova E,
Xiu J,
Lulla AR,
Dicker DT,
El-Deiry WS. Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer.
Cancer Biol Ther. 2017 Sep 2;18(9)
:694-704. PMC ID:PMC5663405. |
|
Finnberg NK,
Gokare P,
Lev A,
Grivennikov SI,
MacFarlane AW,
Campbell KS,
Winters RM,
Kaputa K,
Farma JM,
Abbas AE,
Grasso L,
Nicolaides NC,
El-Deiry WS. Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures.
Oncotarget. 2017 Sep;8(40)
:66747-66757. PMC ID:PMC5620133. |
|
Prabhu VV,
Lulla AR,
Madhukar NS,
Ralff MD,
Zhao D,
Kline CLB,
Van den Heuvel APJ,
Lev A,
Garnett MJ,
McDermott U,
Benes CH,
Batchelor TT,
Chi AS,
Elemento O,
Allen JE,
El-Deiry WS. Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.
PLoS One. 2017 Aug;12(8)
:e0180541. PMC ID:PMC5540272. |
|
Deihimi S,
Lev A,
Slifker M,
Shagisultanova E,
Xu Q,
Jung K,
Vijayvergia N,
Ross EA,
Xiu J,
Swensen J,
Gatalica Z,
Andrake M,
Dunbrack RL,
El-Deiry WS. BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.
Oncotarget. 2017 Jun 20;8(25)
:39945-39962. PMC ID:PMC5522275. |
|
Allen JE,
Kline CL,
Prabhu VV,
Wagner J,
Ishizawa J,
Madhukar N,
Lev A,
Baumeister M,
Zhou L,
Lulla A,
Stogniew M,
Schalop L,
Benes C,
Kaufman HL,
Pottorf RS,
Nallaganchu BR,
Olson GL,
Al-Mulla F,
Duvic M,
Wu GS,
Dicker DT,
Talekar MK,
Lim B,
Elemento O,
Oster W,
Bertino J,
Flaherty K,
Wang ML,
Borthakur G,
Andreeff M,
Stein M,
El-Deiry WS. Discovery and clinical introduction of first-in-class imipridone ONC201.
Oncotarget. 2016 Nov 08;7(45)
:74380-92. PMC ID:PMC5342060. |
|
Simon AJ,
Lev A,
Zhang Y,
Weiss B,
Rylova A,
Eyal E,
Kol N,
Barel O,
Cesarkas K,
Soudack M,
Greenberg-Kushnir N,
Rhodes M,
Wiest DL,
Schiby G,
Barshack I,
Katz S,
Pras E,
Poran H,
Reznik-Wolf H,
Ribakovsky E,
Simon C,
Hazou W,
Sidi Y,
Lahad A,
Katzir H,
Sagie S,
Aqeilan HA,
Glousker G,
Amariglio N,
Tzfati Y,
Selig S,
Rechavi G,
Somech R. Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
J Exp Med. 2016 Jul 25;213(8)
:1429-40. PMC ID:PMC4986528. |
|
Remakus S,
Rubio D,
Lev A,
Ma X,
Fang M,
Xu RH,
Sigal LJ. Memory CD8(+) T Cells Can Outsource IFN-gamma Production but Not Cytolytic Killing for Antiviral Protection.
Cell Host Microbe. 2013 May 15;13(5)
:546-57. |
|
Lev A,
Sigal L. Getting in front and behind the enemy lines to counter virus infection.
Cell Host Microbe. 2013 Feb 13;13(2)
:121-2. |
|
Faculty
Publications
