FCCC Faculty Publications

Cal-Kayitmazbatir S, Kulkoyluoglu-Cotul E, Growe J, Selby CP, Rhoades SD, Malik D, Oner H, Asimgil H, Francey LJ, Sancar A, Kruger WD, Hogenesch JB, Weljie A, Anafi RC, Kavakli IH. CRY1-CBS binding regulates circadian clock function and metabolism. Febs Journal. .

Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. Cancer Discov. 2021 Feb;11(2) :446-479. PMC ID:PMC7858242.

Cal-Kayitmazbatir S, Kulkoyluoglu-Cotul E, Growe J, Selby CP, Rhoades SD, Malik D, Oner H, Asimgil H, Francey LJ, Sancar A, Kruger WD, Hogenesch JB, Weljie A, Anafi RC, Kavakli IH. CRY1-CBS binding regulates circadian clock function and metabolism. FEBS J. 2021 Jan;288(2) :614-639. PMC ID:PMC7648728.

Gu SX, Sonkar VK, Katare PB, Kumar R, Kruger WD, Arning E, Bottiglieri T, Lentz SR, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. J Am Heart Assoc. 2020 Feb 18;9(4) :e013368. PMC ID:PMC7070222.

Gupta S, Gallego-Villar L, Wang L, Lee HO, Nasrallah G, Al-Dewik N, Haberle J, Thony B, Blom HJ, Ben-Omran T, Kruger WD. Analysis of the Qatari R336C Cystathionine beta-Synthase Protein in Mice. J Inherit Metab Dis. 2019 Sep;42(5) :831-838. PMC ID:PMC7336392.

Al-Dewik N, Ali A, Mahmoud Y, Shahbeck N, Ali R, Mahmoud L, Al-Mureikhi M, Al-Mesaifri F, Musa S, El-Akouri K, AlMulla M, Al Saadi R, Nasrallah G, Samara M, Abdoh G, Al Rifai H, Haberle J, Thony B, Kruger W, Blom HJ, Ben-Omran T. Natural History, with Clinical, Biochemical and Molecular Characterization, of Classical Homocystinuria in the Qatari Population. J Inherit Metab Dis. 2019 Sep;42(5) :818-830.

Lee HO, Gallego-Villar L, Grisch-Chan HM, Haeberle J, Thony B, Kruger WD. Treatment of CBS deficiency in mice using a minicircle-based naked DNA vector. Hum Gene Ther. 2019 Sep;30(9) :1093-1100. PMC ID:PMC6761586.

Lee HO, Gallego-Villar L, Grisch-Chan HM, Häberle J, Thöny B, Kruger WD. Treatment of Cystathionine β-Synthase Deficiency in Mice Using a Minicircle-Based Naked DNA Vector. Human Gene Therapy. 2019 Sep;30(9) :1093-1100. PMC ID:PMC6761586.

Ismail HM, Krishnamoorthy N, Al-Dewik N, Zayed H, Mohamed NA, Giacomo VD, Gupta S, Haberle J, Thony B, Blom HJ, Kruger WD, Ben-Omran T, Nasrallah GK. In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies. Hum Mutat. 2019 Feb;40(2) :230-240. PMC ID:PMC6586426.

Gupta S, Kelow S, Wang L, Andrake M, Dunbrack RL Jr, Kruger WD. Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine beta-synthase (CBS) reveal effects on CBS activity but not stability. J Biol Chem. 2018 Sep 7;293(36) :13921-13931. PMC ID:PMC6130948.

Tang B, Lee HO, An SS, Cai KQ, Kruger WD. Specific targeting of MTAP-deleted tumors with a combination of 2'-fluoroadenine and 5'-methylthioadenosine. Cancer Res. 2018 Aug 1;78(15) :4386-4395. PMC ID:PMC6072572.

Lee HO, Wang L, Kuo YM, Andrews AJ, Gupta S, Kruger WD. S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice. Mol Genet Metab Rep. 2018 Jun;15 :15-21. PMC ID:PMC6047060.

Majtan T, Jones W Jr, Krijt J, Park I, Kruger WD, Kozich V, Bassnett S, Bublil EM, Kraus JP. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther. 2018 Mar 7;26(3) :834-844. PMC ID:PMC5910661.

Kruger WD. Cystathionine beta-synthase deficiency: Of mice and men. Mol Genet Metab. 2017 Jul;121(3) :199-205. PMC ID:PMC5526210.

Gallego-Villar L, Hannibal L, Haberle J, Thony B, Ben-Omran T, Nasrallah GK, Dewik AN, Kruger WD, Blom HJ. Cysteamine revisited: repair of arginine to cysteine mutations. J Inherit Metab Dis. 2017 Jul;40(4) :555-567. PMC ID:PMC5740875.

Gupta S, Wang L, Kruger WD. The c.797 G>A (p.R266K) cystathionine beta-synthase mutation causes homocystinuria by affecting protein stability. Hum Mutat. 2017 Jul;38(7) :863-869. PMC ID:PMC5525156.

Lee HO, Uzzo RG, Kister D, Kruger WD. Combination of serum histidine and plasma tryptophan as a potential biomarker to detect clear cell renal cell carcinoma. J Transl Med. 2017 Apr 06;15(1) :72. PMC ID:PMC5383954.

Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Pratico D. Homocysteine modulates 5-lipoxygenase expression level via DNA methylation. Aging Cell. 2017 Apr;16(2) :273-280. PMC ID:PMC5334532.

Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. Faseb j. 2017 Feb;31(2) :598-609.

Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD. Lack of global epigenetic methylation defects in CBS deficient mice. J Inherit Metab Dis. 2017 Jan;40(1) :113-120. PMC ID:PMC5300059.

Gupta S, Wang L, Kruger WD. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. J Inherit Metab Dis. 2016 Jan;39(1) :39-46. PMC ID:PMC4784539.

Kruger WD, Gupta S. The effect of dietary modulation of sulfur amino acids on cystathionine beta synthase-deficient mice. Ann N Y Acad Sci. 2016 Jan;1363(1) :80-90. PMC ID:PMC4801721.

Imbard A, Benoist JF, Esse R, Gupta S, Lebon S, de Vriese AS, de Baulny HO, Kruger W, Schiff M, Blom HJ. High homocysteine induces betaine depletion. Biosci Rep. 2015 Apr 28;35(4) . PMC ID:PMC4613678.

Lee HO, Mustafa A, Hudes GR, Kruger WD. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS One. 2015 ;10(7) :e0131464. PMC ID:PMC4489871.

Fang P, Zhang D, Cheng Z, Yan C, Jiang X, Kruger WD, Meng S, Arning E, Bottiglieri T, Choi ET, Han Y, Yang XF, Wang H. Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis. Diabetes. 2014 Dec;63(12) :4275-90. PMC ID:PMC4237991.

Esse R, Imbard A, Florindo C, Gupta S, Quinlivan EP, Davids M, Teerlink T, Tavares de Almeida I, Kruger WD, Blom HJ, Castro R. Protein arginine hypomethylation in a mouse model of cystathionine beta-synthase deficiency. FASEB J. 2014 Jun;28(6) :2686-95. PMC ID:PMC4021445.

Shlomi T, Fan J, Tang B, Kruger WD, Rabinowitz JD. Quantitation of cellular metabolic fluxes of methionine. Anal Chem. 2014 Feb 4;86(3) :1583-91.

Gupta S, Melnyk SB, Kruger WD. Cystathionine beta-synthase-deficient mice thrive on a low-methionine diet. FASEB J. 2014 Feb;28(2) :781-90. PMC ID:PMC3898656.

Tang B, Kadariya Y, Chen Y, Slifker M, Kruger WD. Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. G3 (Bethesda). 2014 Jan;5(1) :35-44.

Gupta S, Wang LQ, Anderl J, Slifker MJ, Kirk C, Kruger WD. Correction of Cystathionine -Synthase Deficiency in Mice by Treatment with Proteasome Inhibitors. Human Mutation. 2013 Aug;34(8) :1085-1093.

Kadariya Y, Tang B, Wang L, Al-Saleem T, Hayakawa K, Slifker MJ, Kruger WD. Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice. PLoS One. 2013 ;8(6) :e67635.

Tang BQ, Testa JR, Kruger WD. Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biology & Therapy. 2012 Sep;13(11) :1082-1090. PMC ID:PMC3461818.

Zhang DQ, Fang P, Jiang XH, Nelson J, Moore JK, Kruger WD, Berretta RM, Houser SR, Yang XF, Wang H. Severe Hyperhomocysteinemia Promotes Bone Marrow-Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice. Circulation Research. 2012 Jun;111(1) :37-49. PMC ID:PMC3412115 .

Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci FM, Kruger WD, Lentz SR. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood. 2012 Mar;119(13) :3176-3183.

Regnier V, Billard JM, Gupta S, Potier B, Woerner S, Paly E, Ledru A, David S, Luilier S, Bizot JC, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, London J. Brain Phenotype of Transgenic Mice Overexpressing Cystathionine beta-Synthase. Plos One. 2012 Jan;7(1) :e29056. PMC ID:PMC3257219.

Zitserman D, Gupta S, Kruger WD, Karbowniczek M, Roegiers F. The TSC1/2 Complex Controls Drosophila Pigmentation through TORC1-Dependent Regulation of Catecholamine Biosynthesis. PLoS One. 2012 ;7(11) :e48720. PMC ID:PMC3492411.

Knock E, Deng LY, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R. Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair. Journal of Nutritional Biochemistry. 2011 Nov;22(11) :1022-1029.

Mustafa A, Gupta S, Hudes GR, Egleston BL, Uzzo RG, Kruger WD. Serum Amino Acid Levels as a Biomarker for Renal Cell Carcinoma. Journal of Urology. 2011 Oct;186(4) :1206-1212. PMC ID:PMC3180900.

Cheng ZJ, Jiang XH, Kruger WD, Pratico D, Gupta S, Mallilankaraman K, Madesh M, Schafer AI, Durante W, Yang XF, Wang H. Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood. 2011 Aug;118(7) :1998-2006.

Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA, Stro C P. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine beta-synthase activity and methylation capacity. Nutrition Research. 2011 Jul;31(7) :563-571. PMC ID:PMC3156413.

Kadariya Y, Tang BQ, Myers CB, Fukui J, Peterson JR, Kruger WD. Chemical Genetic Screening for Compounds That Preferentially Inhibit Growth of Methylthioadenosine Phosphorylase (MTAP)-Deficient Saccharomyces cerevisiae. Journal of Biomolecular Screening. 2011 Jan;16(1) :44-52. PMC ID:PMC3019245.

Gupta S, Kruger WD. Cystathionine Beta-synthase deficiency causes fat loss in mice. PLoS One. 2011 ;6(11) :e27598. PMC ID:PMC3214081.

Tang BQ, Mustafa A, Gupta S, Melnyk S, James SJ, Kruger WD. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase. Nutrition. 2010 Nov-Dec;26(11-12) :1170-1175. PMC ID:PMC2956870.

Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybuty1)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutrition Research. 2010 Jul;30(7) :492-500. PMC ID:PMC2929918.

Wei Q, Wang L, Wang Q, Kruger WD, Dunbrack RL Jr. Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. Proteins. 2010 Jul;78(9) :2058-74.

Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D. Diet-Induced Hyperhomocysteinemia Increases Amyloid-beta Formation and Deposition in a Mouse Model of Alzheimer's Disease. Current Alzheimer Research. 2010 Mar;7(2) :140-149.

Singh LR, Gupta S, Honig NH, Kraus JP, Kruger WD. Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. PLoS Genet. 2010 Jan;6(1) :e1000807. PMC ID:PMC2795852.

Zhuo JM, Kruger WD, Pratico D. The Herp Protein Pathway is Not Involved in the Pro-Amyloidogenic Effect of Hyperhomocysteinemia. Journal of Alzheimers Disease. 2010 ;20(2) :569-576.

Kadariya Y, Yin B, Tang BQ, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma. Cancer Research. 2009 Jul;69(14) :5961-5969. PMC ID:PMC2757012.

Jakubowski H, Perla-Kajan J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. Faseb Journal. 2009 Jun;23(6) :1721-1727. PMC ID:PMC3221610.

Gupta S, Kuhnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 2009 Mar;23(3) :883-93. PMC ID:PMC2653989.

Singh LR, Kruger WD. Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae. J Biol Chem. 2009 Feb 13;284(7) :4238-45. PMC ID:PMC2640983.

Majtan T, Singh LR, Wang LQ, Kruger WD, Kraus JP. Active Cystathionine beta-Synthase Can Be Expressed in Heme-free Systems in the Presence of Metal-substituted Porphyrins or a Chemical Chaperone. Journal of Biological Chemistry. 2008 Dec;283(50) :34588-34595.

Roy M, Leclerc D, Wu Q, Gupta S, Kruger WD, Rozen R. Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Journal of Cellular Biochemistry. 2008 Oct;105(2) :467-476.

Gupta S, Wang L, Hua X, Krijt J, Kozich V, Kruger WD. Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice. Hum Mutat. 2008 Aug;29(8) :1048-54. PMC ID:PMC2630375.

Mustafa A, Kruger WD. Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. Clin Cancer Res. 2008 Aug 1;14(15) :4935-42.

Dayal S, Jensen MJ, Faraci FM, Kruger WD, Lentz SR. Endothelial Dysfunction and Paradoxical Resistance to Thrombosis in a Transgenic Mouse Model of Severe Hyperhomocysteinemia. . 2008 :661-661.

van Slegtenhorst M, Khabibullin D, Hartman TR, Nicolas E, Kruger WD, Henske EP. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. J Biol Chem. 2007 Aug 24;282(34) :24583-90.

Singh LR, Chen X, Koz ich V, Kruger WD. Chemical chaperone rescue of mutant human cystathionine beta-synthase. Mol Genet Metab. 2007 Aug;91(4) :335-342.

Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS. Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria. Experimental and Molecular Medicine. 2006 Dec;38(6) :652-661.

Pei J, Kruger WD, Testa JR. High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays. Cancer Genet Cytogenet. 2006 Oct 1;170(1) :65-8.

Tang BQ, Kadariya Y, Murphy ME, Kruger WD. The methionine salvage pathway compound 4-methylthio-2oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. BIOCHEMICAL PHARMACOLOGY. 2006 Sep;72(7) :806-815.

Chen X, Wang L, Fazlieva R, Kruger WD. Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. Hum Mutat. 2006 Apr 17;27(5) :474-482.

Wang LQ, Chen XL, Tang BQ, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Human Molecular Genetics. 2005 Aug 1;14(15) :2201-2208.

Jhee KH, Kruger WD. The role of cystathionine beta-synthase in homocysteine metabolism. Antioxidants & Redox Signaling. 2005 May-Jun;7(5-6) :813-822.

Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine ?-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Human Molecular Genetics. 2005 ;14(15) :2201-2208.

Kadariya Y, Nakatani K, Nishioka J, Fujikawa T, Kruger WD, Nobori T. Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y). Biochemical Journal. 2005 Part 1 APR 1;387 :175-183.

Chen XL, Jhee KH, Kruger WD. Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. Journal of Biological Chemistry. 2004 Dec 10;279(50) :52082-52086.

Subhi AL, Tang B, Balsara BR, Altomare DA, Testa JR, Cooper HS, Hoffman JP, Meropol NJ, Kruger WD. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clinical Cancer Research. 2004 Nov 1;10(21) :7290-6.

Wang L, Jhee KH, Hua X, DiBello PM, Jacobsen DW, Kruger WD. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circulation Research. 2004 May 28;94(10) :1318-24.

Wang LQ, Jhee KH, Hua X, DiBello PM, Jacobsen DW, Kruger WD. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circulation Research. 2004 May;94(10) :1318-1324.

Singh RH, Kruger WD, Wang LQ, Pasquali M, Elsas LJ. Cystathionine beta-synthase deficiency: Effects of betaine supplementation after methionine restriction in B6-nonresponsive homocystinuria. Genetics in Medicine. 2004 Mar-Apr;6(2) :90-95.

van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP. Tsc1(+) and tsc2(+) regulate arginine uptake and metabolism in Schizosaccharomyces pombe. Journal of Biological Chemistry. 2004 Mar;279(13) :12706-12713.

Tang BQ, Kruger WD, Chen G, Shen FM, Lin WY, Mboup S, London WT, Evans AA. Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. Journal of Medical Virology. 2004 Jan;72(1) :35-40.

Kruger WD, Wang L, Jhee KH, Singh RH, Elsas LJ. Cystathionine beta-synthase deficiency in Georgia (USA): Correlation of clinical and biochemical phenotype with genotype. Human Mutation. 2003 Dec;22(6) :434-441.

Subhi AL, Diegelman P, Porter CW, Tang BQ, Lu ZCJ, Markham GD, Kruger WD. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. Journal of Biological Chemistry. 2003 Dec;278(50) :49868-49873.

Cheon MS, Bajo M, Kim SH, Claudio JO, Stewart AK, Patterson D, Kruger WD, Kondoh H, Lubec G. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part II). Amino Acids. 2003 Mar;24(1-2) :119-25.

Christopher SA, Diegelman P, Porter CW, Kruger WD. Methylthioadenosine Phosphorylase, a Gene Frequently Codeleted with p16(cdkN2a/ARF), Acts as a Tumor Suppressor in a Breast Cancer Cell Line. Cancer Res. 2002 Nov 15;62(22) :6639-44.

Christopher SA, Melnyk S, James SJ, Kruger WD. S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase. Mol Genet Metab. 2002 Apr;75(4) :335-43.

Guttormsen AB, Ueland PM, Kruger WD, Kim CE, Ose L, Folling I, Refsum H. Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype. Am J Med Genet. 2001 May 1;100(3) :204-13.

Shan X, Dunbrack RL Jr, Christopher SA, Kruger WD. Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis. Hum Mol Genet. 2001 Mar 15;10(6) :635-43.

Nozaki T, Shigeta Y, Saito-Nakano Y, Imada M, Kruger WD. Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma. J Biol Chem. 2001 Mar 2;276(9) :6516-23.

Malinow MR, Duell PB, Williams MA, Kruger WD, Evans AA, Anderson PH, Block PC, Hess DL, Upson BM, Graf EE, Irvin-Jones A, Wang LQ. Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. Lipids. 2001 Suppl. S;36 :S27-S32.

Strizheva GD, Carsillo T, Kruger WD, Sullivan EJ, Ryu JH, Henske EP. The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis. Am J Respir Crit Care Med. 2001 Jan;163(1) :253-8.

Kruger WD. The transsulfuration pathway. Homocysteine in health and disease. 2001 :153-161.

Kruger WD, Evans AA, Wang L, Malinow MR, Duell PB, Anderson PH, Block PC, Hess DL, Graf EE, Upson B. Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Mol Genet Metab. 2000 May;70(1) :53-60.

Kruger WD, Fowler B. Molecular biology of cystathionine b-synthase: interrelationships with homocysteine, pyridoxine, and vascular disease. Homocysteine and Vascular Disease. 2000 :313-333.

Kruger WD, Tew KD. Pharmacogenetics and cancer. Basic Science of Cancer. 2000 :257-270.

Kruger WD. Vitamins and homocysteine metabolism. Vitam Horm. 2000 ;60 :333-52.

Shan X, Wang L, Hoffmaster R, Kruger WD. Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae. J Biol Chem. 1999 Nov 12;274(46) :32613-8.

Lobo A, Naso A, Arheart K, Kruger WD, Abou-Ghazala T, Alsous F, Nahlawi M, Gupta A, Moustapha A, van Lente F, Jacobsen DW, Robinson K. Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B-6 and B-12. American Journal of Cardiology. 1999 Mar 15;83(6) :821-825.

Chen P, Poddar R, Tipa EV, Dibello PM, Moravec CD, Robinson K, Green R, Kruger WD, Garrow TA, Jacobsen DW. Homocysteine metabolism in cardiovascular cells and tissues: Implications for hyperhomocysteinemia and cardiovascular disease. Advances in Enzyme Regulation, Vol 39. 1999 ;39 :93-109.

Taoka S, Ohja S, Shan XY, Kruger WD, Banerjee R. Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity. Journal of Biological Chemistry. 1998 Sep 25;273(39) :25179-25184.

Shan X, Kruger WD. Correction of disease-causing CBS mutations in yeast. Nat Genet. 1998 May;19(1) :91-3.

Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC, Upson BM. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. New England Journal of Medicine. 1998 Apr 9;338(15) :1009-1015.

Kim CE, Gallagher PM, Guttormsen AB, Refsum H, Ueland PM, Ose L, Folling I, Whitehead AS, Tsai MY, Kruger WD. Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria. Human Molecular Genetics. 1997 Dec;6(13) :2213-2221.

Malinow MR, Nieto FJ, Kruger WD, Duell PB, Hess DL, Gluckman RA, Block PC, Holzgang CR, Anderson PH, Seltzer D, Upson B, Lin QR. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arteriosclerosis Thrombosis and Vascular Biology. 1997 Jun;17(6) :1157-1162.

Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD. Cloning, mapping and RNA analysis of the human methionine synthase gene. Human Molecular Genetics. 1996 Dec;5(12) :1851-1858.

Gulati S, Baker P, Li YN, Fowler B, Kruger W, Brody LC, Banerjee R. Defects in human methionine synthase in cblG patients. Human Molecular Genetics. 1996 Dec;5(12) :1859-1865.

Kruger WD (99 publications)