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Francescone R,
Barbosa Vendramini-Costa D,
Franco-Barraza J,
Wagner J,
Muir A,
Lau AN,
Gabitova L,
Pazina T,
Gupta S,
Luong T,
Rollins D,
Malik R,
Thapa RJ,
Restifo D,
Zhou Y,
Cai KQ,
Hensley HH,
Tan Y,
Kruger WD,
Devarajan K,
Balachandran S,
Klein-Szanto AJ,
Wang H,
El-Deiry WS,
Vander Heiden MG,
Peri S,
Campbell KS,
Astsaturov I,
Cukierman E. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression.
Cancer Discov. 2021 Feb;11(2)
:446-479. PMC ID:PMC7858242. |
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Gabitova-Cornell L,
Surumbayeva A,
Peri S,
Franco-Barraza J,
Restifo D,
Weitz N,
Ogier C,
Goldman AR,
Hartman TR,
Francescone R,
Tan Y,
Nicolas E,
Shah N,
Handorf EA,
Cai KQ,
O'Reilly AM,
Sloma I,
Chiaverelli R,
Moffitt RA,
Khazak V,
Fang CY,
Golemis EA,
Cukierman E,
Astsaturov I. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer.
Cancer Cell. 2020 Sep 15;38(4)
:567-583 e11. PMC ID:PMC7572882. |
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Beglyarova N,
Banina E,
Zhou Y,
Mukhamadeeva R,
Andrianov G,
Bobrov E,
Lysenko E,
Skobeleva N,
Gabitova L,
Restifo D,
Pressman M,
Serebriiskii IG,
Hoffman JP,
Paz K,
Behrens D,
Khazak V,
Jablonski SA,
Weiner LM,
Golemis EA,
Astsaturov I. Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer.
Clin Cancer Res. 2016 Dec 15;22(24)
:6153-6163. PMC ID:PMC5161635. |
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Gabitova L,
Restifo D,
Gorin A,
Manocha K,
Handorf E,
Yang DH,
Cai KQ,
Klein-Szanto AJ,
Cunningham D,
Kratz LE,
Herman GE,
Golemis EA,
Astsaturov I. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR.
Cell Rep. 2015 Sep 22;12(11)
:1927-38. PMC ID:PMC4581991. |
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Gabitova L,
Gorin A,
Astsaturov I. Molecular pathways: sterols and receptor signaling in cancer.
Clin Cancer Res. 2014 Jan 1;20(1)
:28-34. PMC ID:PMC3859141. |
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Bagnyukova TV,
Restifo D,
Beeharry N,
Gabitova L,
Li T,
Serebriiskii IG,
Golemis EA,
Astsaturov I. DUSP6 regulates drug sensitivity by modulating DNA damage response.
British Journal of Cancer. 2013 Aug;109(4)
:1063-1071. PMC ID:PMC 3749559. |
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Sukhanova A,
Gorin A,
Serebriiskii IG,
Gabitova L,
Zheng H,
Restifo D,
Egleston BL,
Cunningham D,
Bagnyukova T,
Liu H,
Nikonova A,
Adams GP,
Zhou Y,
Yang DH,
Mehra R,
Burtness B,
Cai KQ,
Klein-Szanto A,
Kratz LE,
Kelley RI,
Weiner LM,
Herman GE,
Golemis EA,
Astsaturov I. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
Cancer Discov. 2013 Jan;3(1)
:96-111. PMC ID:PMC3546138. |
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Gorin A,
Gabitova L,
Astsaturov I. Regulation of cholesterol biosynthesis and cancer signaling.
Current Opinion in Pharmacology. 2012 Dec;12(6)
:710-716. PMC ID:PMC 3504641. |
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