FCCC Faculty Publications

Ye S, Sharipova D, Kozinova M, Klug L, D’Souza J, Belinsky MG, Johnson KJ, Einarson MB, Devarajan K, Zhou Y, Litwin S, Heinrich MC, DeMatteo R, von Mehren M, Duncan JS, Rink L. Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment. JCI Insight. 2021 Jan 25;6(2) . PMC ID:PMC7934848.

von Mehren M, George S, Heinrich MC, Schuetze SM, Yap JT, Yu JQ, Abbott A, Litwin S, Crowley J, Belinsky M, Janeway KA, Hornick JL, Flieder DB, Chugh R, Rink LA, Van den Abbeele AD. Linsitinib (OSI-906) for the treatment of Adult and Pediatric Wild Type Gastrointestinal Stromal Tumors, a SARC Phase II study. Clin Cancer Res. 2020 Apr 15;26(8) :1837-1845.

Belinsky MG, Cai KQ, Zhou Y, Luo B, Pei J, Rink L, von Mehren M. Succinate dehydrogenase deficiency in a PDGFRA mutated GIST. BMC Cancer. 2017 Aug 02;17(1) :512. PMC ID:PMC5541693.

Zook P, Pathak HB, Belinsky MG, Gersz L, Devarajan K, Zhou Y, Godwin AK, von Mehren M, Rink L. Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor. Clin Cancer Res. 2017 Jan 01;23(1) :171-180. PMC ID:PMC5203981.

Belinsky MG, Rink L, Cai KQ, Capuzzi SJ, Hoang Y, Chien J, Godwin AK, von Mehren M. Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case. BMC Cancer. 2015 ;15 :887. PMC ID:PMC4641358.

Belinsky MG, Rink L, Flieder DB, Jahromi MS, Schiffman JD, Godwin AK, von Mehren M. Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors. Genes Chromosomes & Cancer. 2013 Feb;52(2) :214-224. PMC ID:PMC23109135.

Belinsky MG, Rink L, von Mehren M. Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors. Front Oncol. 2013 ;3 :117.

Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs JD, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen ZS, Klein-Szanto AJ, Belinsky MG, Kruh GD. Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice. Cancer Res. 2011 May 15;71(10) :3649-3657. PMC ID:PMC3096848.

Belinsky MG, Skorobogatko YV, Rink L, Pei JM, Cai KQ, Vanderveer LA, Riddell D, Merkel E, Tarn C, Eisenberg BL, von Mehren M, Testa JR, Godwin AK. High Density DNA Array Analysis Reveals Distinct Genomic Profiles in a Subset of Gastrointestinal Stromal Tumors. Genes Chromosomes & Cancer. 2009 Oct;48(10) :886-896. PMC ID:PMC2830286.

Rink L, Skorobogatko Y, Kossenkov AV, Belinsky MG, Pajak T, Heinrich MC, Blanke CD, von Mehren M, Ochs MF, Eisenberg B, Godwin AK. Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor. Molecular Cancer Therapeutics. 2009 Aug;8(8) :2172-2182. PMC ID:PMC2822341.

Belinsky MG, Rink L, Cai KQ, Ochs MF, Eisenberg B, Huang M, von Mehren M, Godwin AK. The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors. Cell Cycle. 2008 Oct;7(19) :2949-55. PMC ID:PMC2626174.

Tian XB, Swift B, Zamek-Gliszczynski MJ, Belinsky MG, Kruh GD, Brouwer KLR. Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers. Drug Metabolism and Disposition. 2008 May;36(5) :911-915.

Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The organic solute transporter alpha-beta, Ost alpha-Ost beta, is essential for intestinal bile acid transport and homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2008 Mar;105(10) :3891-3896.

Li Q, Jiang Q, LaRusso J, Klement JF, Sartorelli AC, Belinsky MG, Kruh GD, Uitto J. Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process. Experimental Dermatology. 2007 Oct;16(10) :853-859.

Guo P, Wang XM, Liu LS, Belinsky MG, Kruh GD, Gallo JM. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007 Apr;43(5) :1789-1795.

Kruh GD, Belinsky MG, Gallo JM, Lee K. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev. 2007 Feb 2;26(1) :5-14.

Belinsky MG, Guo P, Lee K, Zhou F, Kotova E, Grinberg A, Westphal H, Shchaveleva I, Klein-Szanto A, Gallo JM, Kruh GD. Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res. 2007 Jan 1;67(1) :262-8.

Lin DI, Barbash O, Kumar KGS, Weber JD, Harper JW, Klein-Szanto AJP, Rustgi A, Fuchs SY, Diehl JA, Zamek-Gliszczynski MJ, Nezasa KI, Tian XB, Bridges AS, Lee K, Belinsky MG, Kruh GD, Brouwer KLR. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-alpha B crystallin complex Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3(-)/(-) and Abcc4(-)/(-) mice. Molecular Cell. 2006 Dec;319(3) :1485-1491.

Sharma V, Prior JL, Belinsky MG, Kruh GD, Piwnica-Worms D. Characterization of a Ga-67/Ga-68 radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: Validation in multidrug-resistant tumors and at the blood-brain barrier. Journal of Nuclear Medicine. 2005 Feb;46(2) :354-364.

Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Molecular Pharmacology. 2005 Feb;67(2) :545-57.

Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen ZS, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, Kruh GD. Analysis of the in vivo functions of Mrp3. Molecular Pharmacology. 2005 ;68(1) :160-168.

Hopper-Borge E, Chen ZS, Shchaveleva I, Belinsky MG, Kruh GD. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel. Cancer Research. 2004 Jul;64(14) :4927-4930.

Kruh GD, Belinsky MG. The MRP family of drug efflux pumps. Oncogene. 2003 Oct;22(47) :7537-7552.

Guo YP, Kotova E, Chen ZS, Lee K, Hopper-Borge E, Belinsky MG, Kruh GD. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2 ',3 '- dideoxycytidine and 9 '-(2 '-phosphonylmethoxyethyl) adenine. Journal of Biological Chemistry. 2003 Aug 8;278(32) :29509-29514.

Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD. Transport of methotrexate, methotrexate polyglutamates, and 17 beta- estradiol 17-(beta-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport. Cancer Research. 2003 Jul 15;63(14) :4048-4054.

Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Molecular Pharmacology. 2003 Feb;63(2) :351-358.

Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Research. 2002 Nov 1 2002;62(21) :6172-6177.

Lin ZP, Johnson DR, Finch RA, Belinsky MG, Kruh GD, Sartorelli AC. Comparative study of the importance of multidrug resistance-associated protein 1 and P-glycoprotein to drug sensitivity in immortalized mouse embryonic fibroblasts. Molecular Cancer Therapeutics. 2002 Oct;1(12) :1105-1114.

Kruh GD, Zeng H, Rea PA, Liu G, Chen ZS, Lee K, Belinsky MG. MRP subfamily transporters and resistance to anticancer agents. J Bioenerg Biomembr. 2001 Dec;33(6) :493-501.

Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD. Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19) :7225-32.

Chen ZS, Aoki S, Komatsu M, Ueda K, Sumizawa T, Furukawa T, Okumura H, Ren XQ, Belinsky MG, Lee K, Kruh GD, Kobayashi M, Akiyama S. Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function. Int J Cancer. 2001 Jul 1;93(1) :107-13.

Vulevic B, Chen Z, Boyd JT, Davis W Jr, Walsh ES, Belinsky MG, Tew KD. Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2). Cancer Res. 2001 Apr 15;61(8) :3339-47.

Hopper E, Belinsky MG, Zeng H, Tosolini A, Testa JR, Kruh GD. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. Cancer Lett. 2001 Jan 26;162(2) :181-91.

Zeng H, Bain LJ, Belinsky MG, Kruh GD. Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents. Cancer Research. 1999 Dec 1;59(23) :5964-5967.

Belinsky MG, Kruh GD. MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver. Br J Cancer. 1999 Jul;80(9) :1342-9.

Kruh GD, Belinsky MG. Characterization of MOAT-C and MOAT-D, new members of the MRP cMOAT subfamily of transporter proteins - Response. Journal of the National Cancer Institute. 1999 May 19;91(10) :888-889.

Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. Journal of the National Cancer Institute. 1998 Nov 18;90(22) :1735-1741.

Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD. Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein canalicular multispecific organic anion transporter-related transporter. Cancer Research. 1998 Jul 1;58(13) :2741-2747.

Laing NM, Belinsky MG, Kruh GD, Bell DW, Boyd JT, Barone L, Testa JR, Tew KD. Amplification of the ATP-Binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells. Cancer Research. 1998 Apr 1;58(7) :1332-1337.

Paul S, Belinsky MG, Shen HX, Kruh GD. Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein. Biochemistry. 1996 Oct 22;35(42) :13647-13655.

Belinsky M, Jaiswal AK. Nad(P)H-Quinone Oxidoreductase(1) (Dt-Diaphorase) Expression in Normal and Tumor-Tissues. Cancer and Metastasis Reviews. 1993 Jun;12(2) :103-117.

Belinsky MG (41 publications)