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Zayac AS , Evens AM , Danilov A , Smith SD , Jagadeesh D , Leslie LA , Wei C , Kim SH , Naik S , Sundaram S , Reddy N , Farooq U , Kenkre VP , Epperla N , Blum KA , Khan N , Singh D , Alderuccio JP , Godara A , Yazdy MS , Diefenbach C , Rabinovich E , Varma G , Karmali R , Shao Y , Trabolsi A , Burkart M , Martin P , Stettner S , Chauhan A , Choi YK , Straker-Edwards A , Klein A , Churnetski MC , Boughan KM , Berg S , Haverkos BM , Orellana-Noia VM , D'Angelo C , Bond DA , Maliske SM , Vaca R , Magarelli G , Sperling A , Gordon MJ , David KA , Savani M , Caimi P , Kamdar M , Lunning MA , Palmisiano N , Venugopal P , Portell CA , Bachanova V , Phillips T , Lossos IS , Olszewski AJ
Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multi-center cohort study
Haematologica. 2021 Feb 4
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Abstract
Central nervous system (CNS) involvement in Burkitt lymphoma (BL) poses a major therapeutic challenge, and the relative ability of contemporary regimens to treat CNS involvement remains uncertain. We described prognostic significance of CNS involvement and incidence of CNS recurrence/progression after contemporary immunochemotherapy using real-world clinicopathologic data on adults with BL diagnosed between 2009 and 2018 across 30 US institutions. We examined associations between baseline CNS involvement, patient characteristics, complete response (CR) rates, and survival. We also examined risk factors for CNS recurrence. Nineteen percent (120/641) of patients (age 18-88 years) had CNS involvement. It was independently associated with HIV infection, poor performance status, involvement of ≥2 extranodal sites, or bone marrow involvement. First-line regimen selection was unaffected by CNS involvement (P=0.93). Patients with CNS disease had significantly lower rates of CR (59% versus 77% without; P.
Notes
1592-8721 Zayac, Adam S Evens, Andrew M Danilov, Alexey Smith, Stephen D Jagadeesh, Deepa Leslie, Lori A Wei, Catherine Kim, Seo-Hyun Naik, Seema Sundaram, Suchitra Reddy, Nishitha Farooq, Umar Kenkre, Vaishalee P Epperla, Narendranath Blum, Kristie A Khan, Nadia Singh, Daulath Alderuccio, Juan P Godara, Amandeep Yazdy, Maryam Sarraf Diefenbach, Catherine Rabinovich, Emma Varma, Gaurav Karmali, Reem Shao, Yusra Trabolsi, Asaad Burkart, Madelyn Martin, Peter Stettner, Sarah Chauhan, Ayushi Choi, Yun Kyong Straker-Edwards, Allandria Klein, Andreas Churnetski, Michael C Boughan, Kirsten M Berg, Stephanie Haverkos, Bradley M Orellana-Noia, Victor M D'Angelo, Christopher Bond, David A Maliske, Seth M Vaca, Ryan Magarelli, Gabriella Sperling, Amy Gordon, Max J David, Kevin A Savani, Malvi Caimi, Paolo Kamdar, Manali Lunning, Matthew A Palmisiano, Neil Venugopal, Parameswaran Portell, Craig A Bachanova, Veronika Phillips, Tycel Lossos, Izidore S Olszewski, Adam J Journal Article Italy Haematologica. 2021 Feb 4. doi: 10.3324/haematol.2020.270876.