Washington SL 3rd , Cowan JE , Herlemann A , Zuniga KB , Masic S , Nguyen HG , Carroll PR

Influence of pelvic lymph node dissection and node-positive disease on biochemical recurrence, secondary treatment, and survival after radical prostatectomy in men with prostate cancer

Prostate. 2021 Feb;81(2) :102-108

PMID: 33075151    URL: https://www.ncbi.nlm.nih.gov/pubmed/33075151

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BACKGROUND: The benefit of pelvic lymph node dissection (PLND) at radical prostatectomy (RP) remains unclear given the low prevalence of known nodal disease (pN1) and concerns about its therapeutic utility. OBJECTIVE: To characterize the impact of PLND and secondary treatment on oncologic outcomes. DESIGN, SETTING, AND PARTICIPANTS: Cohort study of men who underwent primary RP with PLND for prostate cancer (PCa) at our institution since 2003. Men stratified by nodal status. OUTCOME MEASURES AND STATISTICAL ANALYSIS: Outcomes include biochemical recurrence-free survival (bRFS), overall survival, and PCa-specific mortality (PCSM). Multivariable Cox regression models used for each outcome. RESULTS AND LIMITATIONS: Of 1,543 men who underwent primary RP, 174 (11%) had pN1 disease. Median follow-up was 34 months (interquartile range, 15-62). Seven-year outcomes were similar whether less than or ≥14 LNs dissected. Among node-positive patients, 29% had undetectable (UDT) prostate-specific antigen (PSA), 11% had UDT PSA + adjuvant therapy, and 60% had detectable PSA, and 7-year bRFS differed (75% for UDT PSA, 90% for UDT + adjuvant therapy, 38% for detectable PSA, p < .01). Survival outcomes did not differ. In multivariable analysis, detectable PSA (vs. UDT, HR 5.2, 95% CI 2.0-13.3) associated with worse bRFS. After salvage treatment, 7-year outcomes did not differ between groups. Study limited by retrospective review.

1097-0045 Washington, Samuel L 3rd Orcid: 0000-0002-2467-6115 Cowan, Janet E Herlemann, Annika Zuniga, Kyle B Masic, Selma Nguyen, Hao G Carroll, Peter R UCSF Goldberg-Benioff Program in Cancer Translational Biology/ Journal Article United States Prostate. 2021 Feb;81(2):102-108. doi: 10.1002/pros.24085. Epub 2020 Oct 19.