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Timothy Yen

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Center AffiliationsCancer Biology

Publications (106) (print view)

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Ross KC, Andrews AJ, Marion CD, Yen TJ, Bhattacharjee V. Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non-Small Cell Lung Cancer Cells. Mol Cancer Ther. 2017 Aug;16(8):1596-609.   PMCID: PMC5544579
Ji W, Arnst C, Tipton AR, Bekier ME, Taylor WR, Yen TJ, Liu ST. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Jan;11(4):e0153518.   PMCID: PMC4833387
Ji W, Arnst C, Tipton AR, Bekier ME, Taylor WR, Yen TJ, Liu ST. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Jan;11(4):e0153518.   PMCID: PMC4833387
Arora S, Yan H, Cho I, Fan HY, Luo B, Gai X, Bodian DL, Vockley JG, Zhou Y, Handorf E, Egleston BL, Andrake M, Nicolas E, Serebriiskii I, Yen TJ, Hall MJ, Golemis EA, Enders GH. Genetic Variants That Presdispose to DNA Double-strand Breaks in Lymphocytes from a Subset of Patients With Familial Colorectal Carcinomas. Gastroenterology. 2015 Sep 04;149(7):1872-1883 e9.   PMCID: 4663158
Beeharry N, Di Rora AG, Smith MR, Yen TJ. Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biol Ther. 2015 Jul 15;16(9):1397-406.   PMCID: 4621998
Henry RA, Kuo YM, Bhattacharjee V, Yen TJ, Andrews AJ. Changing the Selectivity of p300 by Acetyl-CoA Modulation of Histone Acetylation. Acs Chemical Biology. 2015 Jan;10(1):146-56.
Beeharry N, Banina E, Hittle J, Skobeleva N, Khazak V, Deacon S, Andrake M, Egleston BL, Peterson JR, Astsaturov I, Yen TJ. Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. Cell cycle (Georgetown, Tex). 2014 Jul;13(14):2172-91.   PMCID: PMC4111673
Bhattacharjee V, Zhou Y, Yen T. A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell cycle (Georgetown, Tex). 2014 Jan;13(24):3839-56.   PMCID: 4615005
Budina-Kolomets A, Balaburski GM, Bondar A, Beeharry N, Yen T, Murphy ME. Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition. Cancer Biology & Therapy. 2014 Feb;15(2):194-9.   PMCID: PMC 3928135
Eytan E, Wang K, Miniowitz-Shemtov S, Sitry-Shevah D, Kaisari S, Yen TJ, Liu ST, Hershko A. Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12019-24.   PMCID: PMC4142996
Lal S, Burkhart RA, Beeharry N, Bhattacharjee V, Londin ER, Cozzitorto JA, Romeo C, Jimbo M, Norris ZA, Yeo CJ, Sawicki JA, Winter JM, Rigoutsos I, Yen TJ, Brody JR. HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells. Cancer Res. 2014 Feb 15;74(4):1128-40.   PMCID: 4353573
Wang K, Sturt-Gillespie B, Hittle JC, Macdonald D, Chan GK, Yen TJ, Liu ST. Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein. The Journal of biological chemistry. 2014 Aug 22;289(34):23928-37.   PMCID: Pmc4156041
Wang K, Sturt-Gillespie B, Hittle JC, Macdonald D, Chan GK, Yen TJ, Liu ST. Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein. J Biol Chem. 2014 Aug 22;289(34):23928-37.   PMCID: Pmc4156041
Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL, Yen T, George DL, Murphy ME. A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent. Molecular Cancer Research. 2013 Mar;11(3):219-29.   PMCID: PMC3606282
Beeharry N, Rattner JB, Caviston JP, Yen T. Centromere fragmentation is a common mitotic defect of S and G(2) checkpoint override. Cell cycle (Georgetown, Tex). 2013 May;12(10):1588-97.   PMCID: PMC 3680538
Hu L, Filippakis H, Huang HM, Yen TJ, Gjoerup OV. Replication Stress and Mitotic Dysfunction in Cells Expressing Simian Virus 40 Large T Antigen. Journal of Virology. 2013 Dec;87(24):13179-92.   PMCID: PMC3838287
Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Molecular Biology of the Cell. 2013 Sep;24(18):2785-94.   PMCID: PMC 3771942
Beeharry N, Rattner JB, Bellacosa A, Smith MR, Yen TJ. Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine. Plos One. 2012 Jan;7(6):e40342.   PMCID: PMC3386996
Michal AM, So CH, Beeharry N, Shankar H, Mashayekhi R, Yen TJ, Benovic JL. G Protein-coupled Receptor Kinase 5 Is Localized to Centrosomes and Regulates Cell Cycle Progression. Journal of Biological Chemistry. 2012 Feb;287(9):6928-40.   PMCID: PMC3307296
Ratushny V, Pathak HB, Beeharry N, Tikhmyanova N, Xiao F, Li T, Litwin S, Connolly DC, Yen TJ, Weiner LM, Godwin AK, Golemis EA. Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. Oncogene. 2012 Mar 08;31(10):1217-27.   PMCID: PMC3204164
The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

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Last updated on Wednesday, September 06, 2017