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William Wuest

Center AffiliationsMolecular Therapeutics

Publications (24) (print view)

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Post SJ, Keohane CE, Rossiter LM, Kaplan AR, Khowsathit J, Matuska K, Karanicolas J, Wuest WM. Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase. ACS infectious diseases. 2020 Apr 14;.
Alkhalifa S, Jennings M, Granata D, Klein M, Wuest WM, Minbiole K, Carnevale V. Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study. Chembiochem. 2019 Dec 20;.
Korobeynikov V, Borakove M, Feng Y, Wuest WM, Koval AB, Nikonova AS, Serebriiskii I, Chernoff J, Borges VF, Golemis EA, Shagisultanova E. Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer. Breast Cancer Res Treat. 2019 Sep;177(2):369-82.   PMCID: PMC6661032
Keohane CE, Steele AD, Fetzer C, Khowsathit J, Van Tyne D, Moynie L, Gilmore MS, Karanicolas J, Sieber SA, Wuest WM. Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. J Am Chem Soc. 2018 Feb 07;140(5):1774-82.   PMCID: PMC5869686
Al-Khalifa SE, Jennings MC, Wuest WM, Minbiole KP. The Development of Next-Generation Pyridinium-Based multiQAC Antiseptics. ChemMedChem. 2017 Feb 20;12(4):280-3.
Allen RA, Jennings MC, Mitchell MA, Al-Khalifa SE, Wuest WM, Minbiole KP. Ester- and amide-containing multiQACs: Exploring multicationic soft antimicrobial agents. Bioorganic & medicinal chemistry letters. 2017 May 15;27(10):2107-12.
Brzozowski RS, Wuest WM. Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics. Chemical biology & drug design. 2017 Feb;89(2):169-91.   PMCID: Review
Jennings MC, Forman ME, Duggan SM, Minbiole KP, Wuest WM. Efflux Pumps May Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus. Chembiochem. 2017 Aug 17;18(16):1573-7.   PMCID: PMC5664203
Rossiter SE, Fletcher MH, Wuest WM. Natural Products as Platforms To Overcome Antibiotic Resistance. Chemical reviews. 2017 Oct 11;117(19):12415-74.   PMCID: PMC5869711
Solinski AE, Koval AB, Brzozowski RS, Morrison KR, Fraboni AJ, Carson CE, Eshraghi AR, Zhou G, Quivey RG, Voelz VA, Buttaro BA, Wuest WM. Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms. J Am Chem Soc. 2017 May 31;139(21):7188-91.   PMCID: PMC5891724
Forman ME, Jennings MC, Wuest WM, Minbiole KP. Building a Better Quaternary Ammonium Compound (QAC): Branched Tetracationic Antiseptic Amphiphiles. ChemMedChem. 2016 Jul 05;11(13):1401-5.
Joyce MD, Jennings MC, Santiago CN, Fletcher MH, Wuest WM, Minbiole KP. Natural product-derived quaternary ammonium compounds with potent antimicrobial activity. J Antibiot (Tokyo). 2016 Apr;69(4):344-7.
Mitchell MA, Iannetta AA, Jennings MC, Fletcher MH, Wuest WM, Minbiole KP. Scaffold-Hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials. Chembiochem. 2015 Nov 02;16(16):2299-303.
Steele AD, Knouse KW, Keohane CE, Wuest WM. Total synthesis and biological investigation of (-)-promysalin. J Am Chem Soc. 2015 Jun 17;137(23):7314-7.
Wakefield AE, Wuest WM, Voelz VA. Molecular Simulation of Conformational Pre-Organization in Cyclic RGD Peptides. Journal of chemical information and modeling. 2015 Apr 27;55(4):806-13.
Ator LE, Jennings MC, McGettigan AR, Paul JJ, Wuest WM, Minbiole KP. Beyond paraquats: Dialkyl 3,3'- and 3,4'-bipyridinium amphiphiles as antibacterial agents. Bioorganic & medicinal chemistry letters. 2014 Aug 15;24(16):3706-9.
Paniak TJ, Jennings MC, Shanahan PC, Joyce MD, Santiago CN, Wuest WM, Minbiole KP. The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms. Bioorganic & medicinal chemistry letters. 2014 Dec 15;24(24):5824-8.
Razavi AM, Wuest WM, Voelz VA. Computational Screening and Selection of Cyclic Peptide Hairpin Mimetics by Molecular Simulation and Kinetic Network Models. J Chem Inf Model. 2014 May;54(5):1425-32.
Slaga TJ, DiGiovanni J, Klein-Szanto AJ. Eleventh International Conference on Carcinogenesis and Risk Assessment Environmental Skin Carcinogenesis: UV- and Chemically Induced Cancer Implications for Risk Assessment. Molecular Carcinogenesis. 1998 Nov;23(3):131.
Smith MR, Xie T, Joshi I, Schilder RJ. Dexamethasone plus retinoids decrease IL-6/IL-6 receptor and induce apoptosis in myeloma cells. British Journal of Haematology. 1998 Sep;102(4):1090-7.
The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

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Last updated on Sunday, August 09, 2020