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Jean P Issa

Center AffiliationsCancer Epigenetics

Publications (56) (print view)

Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SC, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. Roadmap for investigating epigenome deregulation and environmental origins of cancer. International journal of cancer. 2018 Aug 24;142(5):874-82.
Kelly AD, Madzo J, Madireddi P, Kropf P, Good CR, Jelinek J, Issa JJ. Demethylator phenotypes in acute myeloid leukemia. Leukemia. 2018 Mar 07;.
Roboz GJ, Kantarjian HM, Yee KW, Kropf PL, O'Connell CL, Griffiths EA, Stock W, Daver NG, Jabbour E, Ritchie EK, Walsh KJ, Rizzieri D, Lunin SD, Curio T, Chung W, Hao Y, Lowder JN, Azab M, Issa JJ. Dose, schedule, safety, and efficacy of guadecitabine in relapsed or refractory acute myeloid leukemia. Cancer. 2018 Jan 15;124(2):325-34.   PMCID: PMC5814873
Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Nucleic acids research. 2017 Aug 21;45(14):8269-81.   PMCID: PMC5737541
He S, Liu Y, Meng L, Sun H, Wang Y, Ji Y, Purushe J, Chen P, Li C, Madzo J, Issa JP, Soboloff J, Reshef R, Moore B, Gattinoni L, Zhang Y. Ezh2 phosphorylation state determines its capacity to maintain CD8(+) T memory precursors for antitumor immunity. Nat Commun. 2017 Dec 14;8(1):2125.   PMCID: PMC5730609
Kantarjian HM, Roboz GJ, Kropf PL, Yee KW, O'Connell CL, Tibes R, Walsh KJ, Podoltsev NA, Griffiths EA, Jabbour E, Garcia-Manero G, Rizzieri D, Stock W, Savona MR, Rosenblat TL, Berdeja JG, Ravandi F, Rock EP, Hao Y, Azab M, Issa JJ. Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial. Lancet Oncol. 2017 Aug 24;18(10):1317-26.
Kelly AD, Kroeger H, Yamazaki J, Taby R, Neumann F, Yu S, Lee JT, Patel B, Li Y, He R, Liang S, Lu Y, Cesaroni M, Pierce SA, Kornblau SM, Bueso-Ramos CE, Ravandi F, Kantarjian HM, Jelinek J, Issa JP. A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome. Leukemia. 2017 Jan 31;.
Kelly AD, Kroeger H, Yamazaki J, Taby R, Neumann F, Yu S, Lee JT, Patel B, Li Y, He R, Liang S, Lu Y, Cesaroni M, Pierce SA, Kornblau SM, Bueso-Ramos CE, Ravandi F, Kantarjian HM, Jelinek J, Issa JP. A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome. Leukemia. 2017 Oct;31(10):2011-9.   PMCID: PMC5537054
Maegawa S, Lu Y, Tahara T, Lee JT, Madzo J, Liang S, Jelinek J, Colman RJ, Issa JJ. Caloric restriction delays age-related methylation drift. Nat Commun. 2017 Sep 14;8(1):539.   PMCID: PMC5599616
Raynal NJ, Da Costa EM, Lee JT, Gharibyan V, Ahmed S, Zhang H, Sato T, Malouf GG, Issa JJ. Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome. Mol Cancer Ther. 2017 Feb;16(2):397-407.   PMCID: PMC5292054
Sato T, Cesaroni M, Chung W, Panjarian S, Tran A, Madzo J, Okamoto Y, Zhang H, Chen X, Jelinek J, Issa JJ. Transcriptional Selectivity of Epigenetic Therapy in Cancer. Cancer Res. 2017 Jan 15;77(2):470-81.   PMCID: PMC5243171
Sato T, Issa JJ, Kropf P. DNA Hypomethylating Drugs in Cancer Therapy. Cold Spring Harbor perspectives in medicine. 2017 May;7(5).
Bouwmeester MC, Ruiter S, Lommelaars T, Sippel J, Hodemaekers HM, van den Brandhof EJ, Pennings JL, Kamstra JH, Jelinek J, Issa JP, Legler J, van der Ven LT. Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicol Appl Pharmacol. 2016 Jan 15;291:84-96.
Kropf P, Barnes G, Tang B, Pathak A, Issa JP. Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia. Leukemia & lymphoma. 2016 Apr;57(4):935-41.
Overman MJ, Morris V, Moinova H, Manyam G, Ensor J, Lee MS, Eng C, Kee B, Fogelman D, Shroff RT, LaFramboise T, Mazard T, Feng T, Hamilton S, Broom B, Lutterbaugh J, Issa JP, Markowitz SD, Kopetz S. Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin. Oncotarget. 2016 Oct 11;7(41):67495-506.   PMCID: PMC5341892
Raynal NJ, Lee JT, Wang Y, Beaudry A, Madireddi P, Garriga J, Malouf GG, Dumont S, Dettman EJ, Gharibyan V, Ahmed S, Chung W, Childers WE, Abou-Gharbia M, Henry RA, Andrews AJ, Jelinek J, Cui Y, Baylin SB, Gill DL, Issa JP. Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer. Cancer Res. 2016 Mar 15;76(6):1494-505.   PMCID: PMC4794357
Foy JP, Pickering CR, Papadimitrakopoulou VA, Jelinek J, Lin SH, William WN, Frederick MJ, Wang J, Lang W, Feng L, Zhang L, Kim ES, Fan YH, Hong WK, El-Naggar AK, Lee JJ, Myers JN, Issa JP, Lippman SM, Mao L, Saintigny P. New DNA Methylation Markers and Global DNA Hypomethylation Are Associated with Oral Cancer Development. Cancer prevention research (Philadelphia, Pa). 2015 Nov;8(11):1027-35.   PMCID: 4777304
Issa JP, Roboz G, Rizzieri D, Jabbour E, Stock W, O'Connell C, Yee K, Tibes R, Griffiths EA, Walsh K, Daver N, Chung W, Naim S, Taverna P, Oganesian A, Hao Y, Lowder JN, Azab M, Kantarjian H. Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study. Lancet Oncol. 2015 Sep;16(9):1099-110.
Jin C, Qin T, Barton MC, Jelinek J, Issa JJ. Minimal Role of Base Excision Repair in TET-Induced Global DNA Demethylation in HEK293T Cells. Epigenetics. 2015 Oct 06;10(11):1006-13.
Jin C, Qin T, Barton MC, Jelinek J, Issa JP. Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 2015 Jan;10(11):1006-13.   PMCID: PMC4844212
Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015 Dec;18(12):1746-55.   PMCID: PMC4661086
Lowder JN, Taverna P, Issa JJ. Will next-generation agents deliver on the promise of epigenetic hypomethylation therapy?. Epigenomics. 2015 Nov 06;7(7):1083-8.
Malouf GG, Tahara T, Paradis V, Fabre M, Guettier C, Yamazaki J, Long H, Lu Y, Raynal NJ, Jelinek J, Mouawad R, Khayat D, Brugieres L, Raymond E, Issa JP. Methylome sequencing for fibrolamellar hepatocellular carcinoma depicts distinctive features. Epigenetics. 2015 Sep 02;10(9):872-81.
Qin T, Si J, Raynal NJ, Wang X, Gharibyan V, Ahmed S, Hu X, Jin C, Lu Y, Shu J, Estecio MR, Jelinek J, Issa JP. Epigenetic synergy between decitabine and platinum derivatives. Clinical epigenetics. 2015 Jan;7(1):97.   PMCID: PMC4567801
Tsimberidou AM, Said R, Culotta K, Wistuba I, Jelinek J, Fu S, Falchook G, Naing A, Piha-Paul S, Zinner R, Siddik ZH, He G, Hess K, Stewart DJ, Kurzrock R, Issa JP. Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. Clin Epigenetics. 2015 Jan;7(1):29.
van Esterik JC, Vitins AP, Hodemaekers HM, Kamstra JH, Legler J, Pennings JL, Steegenga WT, Lute C, Jelinek J, Issa JP, Dolle ME, van der Ven LT. Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A. Toxicology letters. 2015 Jan 05;232(1):293-300.
Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP. TET2 mutations affect non-CpG island DNA methylation at enhancers and transcription factor binding sites in chronic myelomonocytic leukemia. Cancer Res. 2015 May 13;75(14):2833-43.   PMCID: 4506197
Yamazaki J, Taby R, Jelinek J, Raynal NJ, Cesaroni M, Pierce SA, Kornblau SM, Bueso-Ramos CE, Ravandi F, Kantarjian HM, Issa JP. Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia. Journal of the National Cancer Institute. 2015 Nov 13;108(2).   PMCID: 4862435
Plimack ER, Desai JR, Issa JP, Jelinek J, Sharma P, Vence LM, Bassett RL, Ilagan JL, Papadopoulos NE, Hwu WJ. A phase I study of decitabine with pegylated interferon alpha-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations. Invest New Drugs. 2014 Oct;32(5):969-75.
Plimack ER, Desai JR, Issa JP, Jelinek J, Sharma P, Vence LM, Bassett RL, Ilagan JL, Papadopoulos NE, Hwu WJ. A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: Impact on DNA methylation and lymphocyte populations. Investigational New Drugs. 2014 Oct;32(5):969-75.   PMCID: 4171200
Stewart DJ, Nunez MI, Jelinek J, Hong D, Gupta S, Aldaz M, Issa JP, Kurzrock R, Wistuba. Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. Clin Epigenetics. 2014 Jan;6(1):13.   PMCID: Pmc4094901
Stewart DJ, Nunez MI, Jelinek J, Hong D, Gupta S, Issa JP, Wistuba, Kurzrock R. Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. Clin Epigenetics. 2014 Jan;6(1):2.   PMCID: Pmc3895853
Estecio MR, Gallegos J, Dekmezian M, Lu Y, Liang S, Issa JP. SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters. Molecular cancer research : MCR. 2012 Oct;10(10):1332-42.   PMCID: Pmc3475755
Engstrom PF. Cancer Prevention and Control Priorities for the Year-2000 - a Commentary. Cancer. 1994 Aug 15;74(4):1433-7.
Fan JB, Deyoung J, Lagace R, Lina RA, Xu ZD, Murray JC, Buetow KH, Weissenbach J, Goold RD, Cox DR, Myers RM. Isolation of Yeast Artificial Chromosome Clones from 54 Polymorphic Loci Mapped with High Odds on Human-Chromosome-4. Human molecular genetics. 1994 Feb;3(2):243-6.
Feitelson M, Lega L, Guo JH, Resti M, Rossi ME, Azzari C, Blumberg BS, Vierucci A. Pathogenesis of Posttransfusion Viral-Hepatitis in Children with Beta-Thalassemia. Hepatology (Baltimore, Md). 1994 Mar;19(3):558-68.
Fenning MC, Brown DQ, Chapman JD. Photodosimetry of Interstitial Light Delivery to Solid Tumors. Medical Physics. 1994 Jul;21(7):1149-56.
Flubacher MM, Bear SE, Tsichlis PN. Replacement of Interleukin-2 (Il-2)-Generated Mitogenic Signals by a Mink Cell Focus-Forming (Mcf) or Xenotropic Virus-Induced Il-9-Dependent Autocrine Loop - Implications for Mcf Virus- Induced Leukemogenesis. Journal of Virology. 1994 Dec;68(12):7709-16.
Gasser DL, Sternberg NL, Pierce JC, Goldnersauve A, Feng H, Haq AK, Spies T, Hunt C, Buetow KH, Chaplin DD. P1 and Cosmid Clones Define the Organization of 280 Kb of the Mouse H-2-Complex Containing the Cps-1 and Hsp70 Loci. Immunogenetics. 1994 Jan;39(1):48-55.
Glusker JP. Untitled. Acta Crystallographica Section D-Biological Crystallography. 1994 Jan;50:1.
Johnson SW, Perez RP, Godwin AK, Yeung AT, Handel LM, Ozols RF, Hamilton TC. Role of Platinum-DNA Adduct Formation and Removal in Cisplatin Resistance in Human Ovarian-Cancer Cell-Lines. Biochemical pharmacology. 1994 Feb 11;47(4):689-97.
Johnson SW, Swiggard PA, Handel LM, Brennan JM, Godwin AK, Ozols RF, Hamilton TC. Relationship between Platinum-DNA Adduct Formation and Removal and Cisplatin Cytotoxicity in Cisplatin-Sensitive and Cisplatin-Resistant Human Ovarian-Cancer Cells. Cancer Research. 1994 Nov 15;54(22):5911-6.
Joseph P, Jaiswal AK. Nad(P)H-Quinone Oxidoreductase(1) (Dt Diaphorase) Specifically Prevents the Formation of Benzo a Pyrene Quinone-DNA Adducts Generated by Cytochrome P4501a1 and P450 Reductase. Proceedings of the National Academy of Sciences of the United States of America. 1994 Aug 30;91(18):8413-7.
Joseph P, Jaiswal AK, Stobbe CC, Chapman JD. The Role of Specific Reductases in the Intracellular Activation and Binding of 2-Nitroimidazoles. International Journal of Radiation Oncology Biology Physics. 1994 May 15;29(2):351-5.
Joseph P, Sharma MC, Jaiswal AK. Inhibition of Nad(P)H-Quinone Oxidoreductase(1) in Ethacrynic Acid-Resistant Human Colon-Carcinoma Cells. Biochemical pharmacology. 1994 Jun;47(11):2011-5.
Joseph P, Srinivasan SN, Byczkowski JZ, Kulkarni AP. Bioactivation of Benzo(a)Pyrene-7,8-Dihydrodiol Catalyzed by Lipoxygenase Purified from Human Term Placenta and Conceptal Tissues. Reproductive Toxicology. 1994 Jul;8(4):307-13.
Kaplan EJ, Hanks GE. Use of Transrectal Ultrasound to Stage Prostate-Cancer. JAMA-Journal of the American Medical Association. 1994 Aug 17;272(7):516.
Kariv I, Hardy RR, Hayakawa K. 2 Distinct Non-T Helper Type-2 Interleukin-4(+) Cell Subsets in Mice as Revealed by Single-Cell Cytokine Analysis. European Journal of Immunology. 1994 Mar;24(3):549-57.
Kariv I, Hardy RR, Hayakawa K. Altered Major Histocompatibility Complex Restriction in the Nk1.1(+)Ly-6c(Hi) Autoreactive Cd4(+) T-Cell Subset from Class Ii-Deficient Mice. Journal of Experimental Medicine. 1994 Dec;180(6):2419-24.
Katz RA, Skalka AM. The Retroviral Enzymes. Annual Review of Biochemistry. 1994 Jan;63:133-73.
Khan SH, Sorof S. Liver Fatty-Acid-Binding Protein - Specific Mediator of the Mitogenesis Induced by 2 Classes of Carcinogenic Peroxisome Proliferators. Proceedings of the National Academy of Sciences of the United States of America. 1994 Feb;91(3):848-52.
King ES, Rimer BK, Seay J, Balshem A, Engstrom PF. Promoting Mammography Use through Progressive Interventions - Is It Effective. American journal of public health. 1994 Jan;84(1):104-6.
Kleinszanto AJ, Silvers WK, Mintz B. Ultraviolet Radiation-Induced Malignant Skin Melanoma in Melanoma-Susceptible Transgenic Mice. Cancer Research. 1994 Sep;54(17):4569-72.
Krigel RL, Palackdharry CS, Padavic K, Haas N, Kilpatrick D, Langer C, Comis R. Ifosfamide, Carboplatin, and Etoposide Plus Granulocyte- Macrophage Colony-Stimulating Factor - a Phase-I Study with Apparent Activity in Non-Small-Cell Lung-Cancer. Journal of Clinical Oncology. 1994 Jun;12(6):1251-8.
Kruh GD, Chan A, Myers K, Gaughan K, Miki T, Aaronson SA. Expression Complementary-DNA Library Transfer Establishes Mrp as a Multidrug-Resistance Gene. Cancer Research. 1994 Apr;54(7):1649-52.
Komaki R, Pajak TF, Byhardt RW, Emami B, Asbell SO, Roach M, Pedersen JE, Curran WJ, Lattin P, Russell AH, Cox JD. Analysis of Early and Late Deaths on Rtog Nonsmall Cell- Carcinoma of the Lung Trials - Comparison with Calgb-8433. Lung Cancer. 1993 Dec;10(3-4):189-97.
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Last updated on Tuesday, June 05, 2018