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Luis Sigal

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Center AffiliationsBlood Cell Development and Function

Publications (41) (print view)

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Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell host & microbe. 2016 Nov 09;20(5):674-81.
Fang M, Remakus S, Roscoe F, Ma X, Sigal LJ. CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization. J Virol. 2015 Jan;89(1):776-83.   PMCID: PMC4301148
Fang M, Remakus S, Roscoe F, Ma XY, Sigal LJ. CD4(+) T Cell Help Is Dispensable for Protective CD8(+) T Cell Memory against Mousepox Virus following Vaccinia Virus Immunization. J Virol. 2015 Jan;89(1):776-83.
Fang M, Sigal LJ. Protective CD8+ T cell memory without help. Oncotarget. 2015 Sep;6(30):28529-30.
Fang M, Sigal LJ. Protective CD8+ T cell memory without help. Oncotarget. 2015 Oct 06;6(30):28529-30.   PMCID: PMC4745671
Gritsina G, Xiao F, O'Brien SW, Gabbasov R, Maglaty MA, Xu R, Thapa RJ, Zhou Y, Nicolas E, Litwin S, Balachandran S, Sigal LJ, Huszar D, Connolly DC. Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. Molecular Cancer Therapeutics. 2015 Apr;14(4):1035-47.   PMCID: 4394029
Gritsina G, Xiao F, O'Brien SW, Gabbasov R, Maglaty MA, Xu RH, Thapa RJ, Zhou Y, Nicolas E, Litwin S, Balachandran S, Sigal LJ, Huszar D, Connolly DC. Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth. Mol Cancer Ther. 2015 Apr;14(4):1035-47.   PMCID: PMC4394029
Nair S, Fang M, Sigal LJ. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment. Aging cell. 2015 Jan;14(2):180-90.   PMCID: 4364830
Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 2015 Dec 15;43(6):1148-59.   PMCID: PMC4684903
Siciliano NA, Hersperger AR, Lacuanan AM, Xu RH, Sidney J, Sette A, Sigal LJ, Eisenlohr LC. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses. J Virol. 2014 Sep;88(17):10078-91.   PMCID: 4136331
Lev A, Sigal L. Getting in front and behind the enemy lines to counter virus infection. Cell host & microbe. 2013 Feb 13;13(2):121-2.   PMCID: not NIH funded
Ma X, Xu RH, Roscoe F, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ. The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy. J Virol. 2013 Jun;87(12):7046-53.   PMCID: 3676127
Remakus S, Rubio D, Lev A, Ma X, Fang M, Xu RH, Sigal LJ. Memory CD8(+) T Cells Can Outsource IFN-gamma Production but Not Cytolytic Killing for Antiviral Protection. Cell host & microbe. 2013 May 15;13(5):546-57.   PMCID: 3662238
Remakus S, Sigal LJ. Memory CD8(+) T cell protection. Adv Exp Med Biol. 2013 Jan;785:77-86.   PMCID: Invited Review
Rubio D, Xu RH, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcami A, Norbury CC, Sigal LJ. Crosstalk between the Type 1 Interferon and Nuclear Factor Kappa B Pathways Confers Resistance to a Lethal Virus Infection. Cell host & microbe. 2013 Jun 12;13(6):701-10.   PMCID: 3688842
Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma XY, Shamsedeen AR, Eisenlohr LC, Sigal LJ. Perforin-dependent CD4(+) T-cell cytotoxicity contributes to control a murine poxvirus infection. Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun;109(25):9983-8.   PMCID: PMC3382508
Remakus S, Rubio D, Ma XY, Sette A, Sigal LJ. Memory CD8(+) T Cells Specific for a Single Immunodominant or Subdominant Determinant Induced by Peptide-Dendritic Cell Immunization Protect from an Acute Lethal Viral Disease. Journal of Virology. 2012 Sep;86(18):9748-59.   PMCID: PMC3446599
Roscoe F, Xu RH, Sigal LJ. Characterization of Ectromelia Virus Deficient in EVM036, the Homolog of Vaccinia virus F13L, and Its Application for Rapid Generation of Recombinant Viruses. Journal of Virology. 2012 Dec;86(24):13501-7.   PMCID: PMC3503138
Xu RH, Rubio D, Roscoe F, Krouse TE, Truckenmiller ME, Norbury CC, Hudson PN, Damon IK, Alcami A, Sigal LJ. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver. PLoS Pathog. 2012 Jan;8(1):e1002475.   PMCID: PMC3252373
Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease. Immunity. 2011 Apr 22;34(4):579-89.   PMCID: PMC3081423
The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

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Last updated on Thursday, November 02, 2017