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Warren Kruger

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Center AffiliationsCancer Biology

Publications (96) (print view)

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Gupta S, Kelow S, Wang L, Andrake M, Dunbrack RL, Kruger WD. Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine beta-synthase (CBS) reveal effects on CBS activity but not stability. The Journal of biological chemistry. 2018 Sep 07;293(36):13921-31.   PMCID: PMC6130948
Ismail HM, Krishnamoorthy N, Al-Dewik N, Zayed H, Mohamed NA, Giacomo VD, Gupta S, Haberle J, Thony B, Blom HJ, Kruger WD, Ben-Omran T, Nasrallah GK. In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies. Hum Mutat. 2018 Nov 08;.
Lee HO, Wang L, Kuo YM, Andrews AJ, Gupta S, Kruger WD. S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice. Molecular Genetics and Metabolism Reports. 2018 Jan;15:15-21.
Lee HO, Wang L, Kuo YM, Andrews AJ, Gupta S, Kruger WD. S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice. Mol Genet Metab Rep. 2018 Jun;15:15-21.   PMCID: PMC6047060
Majtan T, Jones W, Krijt J, Park I, Kruger WD, Kozich V, Bassnett S, Bublil EM, Kraus JP. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Molecular therapy : the journal of the American Society of Gene Therapy. 2018 Mar 07;26(3):834-44.   PMCID: PMC5910661
Tang B, Lee HO, An SS, Cai KQ, Kruger WD. Specific targeting of MTAP-deleted tumors with a combination of 2'-fluoroadenine and 5'-methylthioadenosine. Cancer Res. 2018 Aug;78(15):4386-95.   PMCID: PMC6072572
Gallego-Villar L, Hannibal L, Haberle J, Thony B, Ben-Omran T, Nasrallah GK, Dewik AN, Kruger WD, Blom HJ. Cysteamine revisited: repair of arginine to cysteine mutations. J Inherit Metab Dis. 2017 Jul;40(4):555-67.   PMCID: PMC5740875
Gupta S, Wang L, Kruger WD. The c.797 G>A (p.R266K) cystathionine beta-synthase mutation causes homocystinuria by affecting protein stability. Hum Mutat. 2017 Jul;38(7):863-9.   PMCID: PMC5525156
Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. Faseb j. 2017 Feb;31(2):598-609.
Kruger WD. Cystathionine beta-synthase deficiency: Of mice and men. Molecular genetics and metabolism. 2017 Jul;121(3):199-205.   PMCID: PMC5526210
Lee HO, Uzzo RG, Kister D, Kruger WD. Combination of serum histidine and plasma tryptophan as a potential biomarker to detect clear cell renal cell carcinoma. Journal of translational medicine. 2017 Apr 06;15(1):72.   PMCID: PMC5383954
Lee HO, Uzzo RG, Kister D, Kruger WD. Combination of serum histidine and plasma tryptophan as a potential biomarker to detect clear cell renal cell carcinoma. Journal of translational medicine. 2017 Apr 06;15(1):72.   PMCID: PMC5383954
Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD. Lack of global epigenetic methylation defects in CBS deficient mice. J Inherit Metab Dis. 2017 Jan;40(1):113-20.   PMCID: PMC5300059
Lee HO, Wang LQ, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD. Lack of global epigenetic methylation defects in CBS deficient mice. Journal of Inherited Metabolic Disease. 2017 Jan;40(1):113-20.
Lee HO, Wang LQ, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD. Lack of global epigenetic methylation defects in CBS deficient mice. Journal of Inherited Metabolic Disease. 2017 Jan;40(1):113-20.   PMCID: PMC5300059
Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Pratico D. Homocysteine modulates 5-lipoxygenase expression level via DNA methylation. Aging cell. 2017 Apr;16(2):273-80.   PMCID: PMC5334532
Gupta S, Wang L, Kruger WD. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. J Inherit Metab Dis. 2016 Aug;39(1):39-46.   PMCID: 4784539
Kruger WD, Gupta S. The effect of dietary modulation of sulfur amino acids on cystathionine beta synthase-deficient mice. Ann N Y Acad Sci. 2016 Jan;1363(1):80-90.   PMCID: PMC4801721
Imbard A, Benoist JF, Esse R, Gupta S, Lebon S, de Vriese AS, de Baulny HO, Kruger W, Schiff M, Blom HJ. High homocysteine induces betaine depletion. Biosci Rep. 2015 Apr 28;35(4).   PMCID: 4613678
Lee HO, Mustafa A, Hudes GR, Kruger WD. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS One. 2015 Jan;10(7):e0131464.   PMCID: PMC4489871
The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

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Last updated on Tuesday, December 04, 2018