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Eileen Jaffe

Center AffiliationsMolecular Therapeutics

Publications (66) (print view)

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Ge Y, Borne E, Stewart S, Hansen MR, Arturo EC, Jaffe EK, Voelz VA. Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding. The Journal of biological chemistry. 2018 Dec 21;293(51):19532-43.   PMCID: PMC6314134
Jaffe EK. New protein structures provide an updated understanding of phenylketonuria. Molecular genetics and metabolism. 2017 Jun 15;121(4):289-96.   PMCID: PMC5549558
Arturo EC, Gupta K, Heroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proc Natl Acad Sci U S A. 2016 Mar;113(9):2394-9.   PMCID: PMC4780608
Jaffe EK. The Remarkable Character of Porphobilinogen Synthase. Accounts of chemical research. 2016 Nov 15;49(11):2509-17.   PMCID: PMC5148690
Ramirez UD, Nikonova AS, Liu H, Pecherskaya A, Lawrence SH, Serebriiskii IG, Zhou Y, Robinson MK, Einarson MB, Golemis EA, Jaffe EK. Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization. BMC cancer. 2015 Jan;15:436.   PMCID: 4451962
Lentz CS, Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, Famulok M, Hoerauf A, Pfarr KM. wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs. Journal of medicinal chemistry. 2014 Mar;57(6):2498-510.   PMCID: PMC 3983392
Jaffe EK. Impact of Quaternary Structure Dynamics on Allosteric Drug Discovery. Current topics in medicinal chemistry. 2013 Jan;13(1):55-63.   PMCID: PMC3631351
Jaffe EK, Stith L, Lawrence SH, Andrake M, Dunbrack RL. A new model for allosteric regulation of phenylalanine hydroxylase: Implications for disease and therapeutics. Arch Biochem Biophys. 2013 Feb 15;530(2):73-82.   PMCID: 3580015
Jaffe EK, Lawrence SH. The morpheein model of allostery: evaluating proteins as potential morpheeins. Methods Mol Biol. 2012 Jan;796:217-31.   PMCID: PMC3256758
Jaffe EK, Lawrence SH. Allostery and the dynamic oligomerization of porphobilinogen synthase. Arch Biochem Biophys. 2012 Mar 15;519(2):144-53.   PMCID: PMC3291741
Selwood T, Jaffe EK. Dynamic dissociating homo-oligomers and the control of protein function. Arch Biochem Biophys. 2012 Mar 15;519(2):131-43.   PMCID: PMC3298769
Velvadapu V, McDonnell ME, Jaffe EK, Reitz AB. Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one. Tetrahedron Letters. 2012 Jun;53(25):3144-6.   PMCID: PMC3398704
Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS. Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase: INSIGHTS ON OCTAMERIC STRUCTURE AND PORPHOBILINOGEN FORMATION. The Journal of biological chemistry. 2011 Apr 29;286(17):15298-307.   PMCID: PMC3083160
Lawrence SH, Selwood T, Jaffe EK. Diverse Clinical Compounds Alter the Quaternary Structure and Inhibit the Activity of an Essential Enzyme. ChemMedChem. 2011 Jun;6(6):1067-73.   PMCID: PMC3236527
Jaffe EK. Morpheeins - A New Pathway for Allosteric Drug Discovery. The Open Conference Proceedings Journal. 2010 Jan;1:1-6.   PMCID: PMC3107518
Ramirez UD, Myachina F, Stith L, Jaffe EK. Docking to large allosteric binding sites on protein surfaces. Advances in experimental medicine and biology. 2010 Jan;680:481-8.   PMCID: PMC2946403
Reitz AB, Ramirez UD, Stith L, Du YM, Smith GR, Jaffe EK. Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies. Arkivoc. 2010 Jan;:175-88.   PMCID: PMC3106444
Shanmugam D, Wu B, Ramirez U, Jaffe EK, Roos DS. Plastid-associated Porphobilinogen Synthase from Toxoplasma gondii KINETIC AND STRUCTURAL PROPERTIES VALIDATE THERAPEUTIC POTENTIAL. Journal of Biological Chemistry. 2010 Jul;285(29):22122-31.   PMCID: PMCID: PMC2903393 [Available on 2011/7/16]
Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK. Allosteric inhibition of human porphobilinogen synthase. The Journal of biological chemistry. 2009 Dec 18;284(51):35807-17.   PMCID: 2791010
Kokona B, Rigotti DJ, Wasson AS, Lawrence SH, Jaffe EK, Fairman R. Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation. Biochemistry. 2008 Oct;47(40):10649-56.
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Last updated on Thursday, May 02, 2019