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Kyoko Hayakawa

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Center AffiliationsBlood Cell Development and Function

Publications (65) (print view)

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Hayakawa K, Formica AM, Zhou Y, Ichikawa D, Asano M, Li YS, Shinton SA, Brill-Dashoff J, Nunez G, Hardy RR. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. J Exp Med. 2017 Oct 02;214(10):3067-83.   PMCID: PMC5626402
Liu X, Li YS, Shinton SA, Rhodes J, Tang L, Feng H, Jette CA, Look AT, Hayakawa K, Hardy RR. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017 Sep;199(5):1706-15.   PMCID: PMC5563169
Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC, Hardy RR. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression. Journal of Experimental Medicine. 2016 Dec;213(13):3007-23.
Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC, Hardy RR. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression. J Exp Med. 2016 Dec;213(13):3007-24.   PMCID: PMC5154941
Hayakawa K, Formica AM, Colombo MJ, Shinton SA, Brill-Dashoff J, Morse Iii HC, Li YS, Hardy RR. Loss of a chromosomal region with synteny to human 13q14 occurs in mouse chronic lymphocytic leukemia that originates from early-generated B-1 B cells. Leukemia. 2016 Mar 08;30(7):1510-9.   PMCID: PMC4979312
Hardy RR, Hayakawa K. Selection of natural autoreactive B cells. Clin Exp Rheumatol. 2015 Sep;33(4 Suppl 92):S80-6.
Hardy RR, Hayakawa K. Perspectives on fetal derived CD5(+) B1 B cells. Eur J Immunol. 2015 Nov;45(11):2978-84.   PMCID: 4674377
Hayakawa K, Formica AM, Colombo MJ, Ichikawa D, Shinton SA, Brill-Dashoff J, Hardy RR. B cells generated by B-1 development can progress to chronic lymphocytic leukemia. Ann N Y Acad Sci. 2015 Apr 23;1362(1):250-5.
Ichikawa D, Asano M, Shinton SA, Brill-Dashoff J, Formica AM, Velcich A, Hardy RR, Hayakawa K. Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells. J Immunol. 2015 Jan 15;194(2):606-14.   PMCID: PMC4282382
Li YS, Zhou Y, Tang L, Shinton SA, Hayakawa K, Hardy RR. A developmental switch between fetal and adult B lymphopoiesis. Ann N Y Acad Sci. 2015 Dec;1362(1):8-15.
Zhou Y, Li YS, Bandi SR, Tang L, Shinton SA, Hayakawa K, Hardy RR. Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a. Journal of Experimental Medicine. 2015 Apr 06;212(4):569-80.   PMCID: 4387290
Kadariya Y, Tang B, Wang L, Al-Saleem T, Hayakawa K, Slifker MJ, Kruger WD. Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice. PLoS One. 2013 Jan;8(6):e67635.   PMCID: 3694069
Hardy RR, Hayakawa K. Positive and negative selection of natural autoreactive B cells. Adv Exp Med Biol. 2012 Jan;750:227-38.
Florence WC, Xia CF, Gordy LE, Chen WL, Zhang YL, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. Embo Journal. 2009 Nov;28(22):3579-90.   PMCID: PMC2782097
Rowley B, Tang L, Shinton S, Hayakawa K, Hardy RR. Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors. Journal of Autoimmunity. 2007 Jan;29(4):236-45.
Hardy RR, Hayakawa K. Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes. Springer Seminars in Immunopathology. 2005 Mar;26(4):363-75.
Wen L, Brill-Dashoff J, Shinton SA, Asano M, Hardy RR, Hayakawa K. Evidence of marginal-zone B cell-positive selection in spleen.[see comment]. Immunity. 2005 Sep;23(3):297-308.
Wen L, Shinton SA, Hardy RR, Hayakawa K. Association of B-1 B Cells with Follicular Dendritic Cells in Spleen. Journal of Immunology. 2005 Jan;174(11):6918-26.
Wen LJ, Brill-Dashoff J, Shinton SA, Asano M, Hardy RR, Hayakawa K. Evidence of marginal-zone B cell-positive selection in spleen. Immunity. 2005 Sep;23(3):297-308.
Hardy R, Hayakawa K. Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes. Springer Seminars in Immunopathology. 2004 Dec;eFIRST date:21.
Hardy RR, Wei CJ, Hayakawa K. Selection during development of V(H)11(+)B cells: a model for natural autoantibody-producing CD5(+) B cells. Immunological reviews. 2004 Feb;197:60-74.
Hayakawa K, Asano M, Shinton SA, Gui M, Wen LJ, Dashoff J, Hardy RR. Positive selection of anti-Thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. Journal of Experimental Medicine. 2003 Jan;197(1):87-99.
Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, Joyce S. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antiqen caused by beta-D-glucosylceramide synthase deficiency. Proceedings of the National Academy of Sciences of the United States of America. 2003 Feb;100(4):1849-54.
Roberts TJ, Sriram V, Spence PM, Gui M, Hayakawa K, Bacik I, Bennink JR, Yewdell JW, Brutkiewicz RR. Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells. Journal of Immunology. 2002 Jun;168(11):5409-14.
Sriram V, Cho S, Li P, O'Donnell PW, Dunn C, Hayakawa K, Blum JS, Brutkiewicz RR. Inhibition of glycolipid shedding rescues recognition of a CD1(+) T cell lymphoma by natural killer T (NKT) cells. Proceedings of the National Academy of Sciences of the United States of America. 2002 Jun 11;99(12):8197-202.
Gui M, Li J, Wen LJ, Hardy RR, Hayakawa K. TCR beta chain influences but does not solely control autoreactivity of V alpha 14J281T cells. J Immunol. 2001 Dec;167(11):6239-46.
Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol. 2001 Jan;19:595-621.
Hardy RR, Li YS, Allman D, Asano M, Gui M, Hayakawa K. B-cell commitment, development and selection. Immunological reviews. 2000 Jun;175:23-32.
Hardy RR, Wasserman R, Li YS, Shinton SA, Hayakawa K. Response by B cell precursors to pre-B receptor assembly: differences between fetal liver and bone marrow. Curr Top Microbiol Immunol. 2000 Jan;252:25-30.
Hayakawa K, Hardy RR. Development and function of B-1 cells. Curr Opin Immunol. 2000 Jun;12(3):346-53.
Hayakawa K, Shinton SA, Asano M, Hardy RR. B-1 cell definition. Curr Top Microbiol Immunol. 2000 Jan;252:15-22.
Gui M, Wiest DL, Li J, Kappes D, Hardy RR, Hayakawa K. Peripheral CD4(+) T cell maturation recognized by increased expression of Thy-1/CD90 bearing the 6C10 carbohydrate epitope. Journal of Immunology. 1999 Nov;163(9):4796-804.
Hayakawa K, Asano M, Shinton SA, Gui M, Allman D, Stewart CL, Silver J, Hardy RR. Positive selection of natural autoreactive B cells. Science. 1999 Jul 02;285(5424):113-6.
Burdin N, Brossay L, Koezuka Y, Smiley ST, Grusby MJ, Gui M, Taniguchi M, Hayakawa K, Kronenberg M. Selective ability of mouse CD1 to present glycolipids: alpha- Galactosylceramide specifically stimulates V alpha 14(+) NK T lymphocytes. Journal of Immunology. 1998 Oct;161(7):3271-81.
Maier CC, Bhandoola A, Borden W, Yui K, Hayakawa K, Greene MI. Unique molecular surface features of in vivo tolerized T cells. Proceedings of the National Academy of Sciences of the United States of America. 1998 Apr 14;95(8):4499-503.
Wasserman R, Li YS, Shinton SA, Carmack CE, Manser T, Wiest DL, Hayakawa K, Hardy RR. A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. Journal of Experimental Medicine. 1998 Jan 19;187(2):259-64.
Hayakawa K, Li YS, Wasserman R, Sauder S, Shinton S, Hardy RR. B lymphocyte developmental lineages. Ann N Y Acad Sci. 1997 Apr 05;815:15-29.
Li YS, Wasserman R, Hayakawa K, Hardy RR. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 1996 Dec;5(6):527-35.
Hardy RR, Hayakawa K. B-lineage differentiation stages resolved by multiparameter flow cytometry. In: Immunoglobulin Gene Expression in Development and Disease. 1995. p. 19-24.
Dittrich F, Hayakawa K, Nimtz M, Ebel F, Muhlradt PF. Identification of the Mouse Helper T-Lymphocyte Differentiation Antigen 3g11 as Tbe Ganglioside Iv3(Neuac)(2)-Ggose(4)Cer. Biochemical and Biophysical Research Communications. 1994 May 16;200(3):1557-63.
Hardy RR, Carmack CE, Li YS, Hayakawa K. Distinctive Developmental Origins and Specificities of Murine Cd5(+)B Cells. Immunological reviews. 1994 Feb;137:91-118.
Hardy RR, Hayakawa K. Cd5 B-Cells, a Fetal B-Cell Lineage. In: Advances in Immunology, Vol 55. 1994. p. 297-339.
Hayakawa K, Tarlinton D, Hardy RR. Absence of Mhc Class-Ii Expression Distinguishes Fetal from Adult B-Lymphopoiesis in Mice. Journal of Immunology. 1994 May 15;152(10):4801-7.
Kariv I, Hardy RR, Hayakawa K. 2 Distinct Non-T Helper Type-2 Interleukin-4(+) Cell Subsets in Mice as Revealed by Single-Cell Cytokine Analysis. European Journal of Immunology. 1994 Mar;24(3):549-57.
Kariv I, Hardy RR, Hayakawa K. Altered Major Histocompatibility Complex Restriction in the Nk1.1(+)Ly-6c(Hi) Autoreactive Cd4(+) T-Cell Subset from Class Ii-Deficient Mice. Journal of Experimental Medicine. 1994 Dec;180(6):2419-24.
Greer JM, Koerner TA, Hayakawa K, Hardy RR, Kemp JD. The 3g11+ Antigen, a Marker for Murine Cd4+ Th1 Lymphocytes, Is a Ganglioside. Glycobiology. 1993 Aug;3(4):391-401.
Kariv I, Hardy RR, Hayakawa K. Selective Enrichment of Major Histocompatibility Complex Class Ii-Specific Autoreactive T-Cells in the Thymic Thy0 Subset. Journal of Experimental Medicine. 1993 May;177(5):1429-37.
Li YS, Hayakawa K, Hardy RR. The Regulated Expression of B-Lineage Associated Genes During B-Cell Differentiation in Bone-Marrow and Fetal Liver. Journal of Experimental Medicine. 1993 Sep;178(3):951-60.
Hardy R, Hayakawa K. Generation of Ly-1 B-Cells from Developmentally Distinct Precursors - Enrichment by Stromal-Cell Culture or Cell Sorting. Annals of the New York Academy of Sciences. 1992 May 04;651:99-111.
Hary RR, Shinton SA, Hayakawa K. Repopulation of SCID mice with fetal-derived B-lineage cells. Current Topics in Microbiology and Immunology. 1992 Jan;182:73-80.
Hayakawa K, Carmack CE, Shinton SA, Hardy RR. Selection of Autoantibody Specificities in the Ly-1 B Subset. Annals of the New York Academy of Sciences. 1992 May 04;651:346-53.
Hayakawa K, Lin BT, Hardy RR. Murine Cd4+ T-Cell Subsets Generated by Antigen-Independent and Dependent Mechanisms. Chemical Immunology. 1992 Jan;54:103-16.
Hayakawa K, Lin BT, Hardy RR. Murine Thymic Cd4+ T-Cell Subsets - a Subset (Thyo) That Secretes Diverse Cytokines and Overexpresses the V-Beta-8 T- Cell Receptor Gene Family. Journal of Experimental Medicine. 1992 Jul;176(1):269-74.
Rogers PR, Pilapil S, Hayakawa K, Romain PL, Parker DC. Cd45 Alternative Exon Expression in Murine and Human Cd4+ T- Cell Subsets. Journal of Immunology. 1992 Jun 15;148(12):4054-65.
Greer JM, Koerner TA, Hayakawa K, Hardy RR, Kemp JD. Functional Subsets of Murine Cd4+ T-Cells Are Defined, in Part, by Expression of a Novel Ganglioside. Faseb Journal. 1991 Mar 19;5(6):A1692-A1692.
Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and Characterization of Pro-B and Pre-Pro-B Cell Stages in Normal Mouse Bone-Marrow. Journal of Experimental Medicine. 1991 May;173(5):1213-25.
Hardy RR, Hayakawa K. A Developmental Switch in B-Lymphopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 1991 Dec;88(24):11550-4.
Hayakawa K, Hardy RR. Murine Cd4+ T-Cell Subsets. Immunological reviews. 1991 Oct;123:145-68.
Carmack CE, Shinton SA, Hayakawa K, Hardy RR. Rearrangement and Selection of Vh11 in the Ly-1 B-Cell Lineage. Journal of Experimental Medicine. 1990 Jul;172(1):371-4.
Cerny A, Hugin AW, Hardy RR, Hayakawa K, Zinkernagel RM, Makino M, Morse HC. B-Cells Are Required for Induction of T-Cell Abnormalities in a Murine Retrovirus-Induced Immunodeficiency Syndrome. Journal of Experimental Medicine. 1990 Jan;171(1):315-20.
Ernst DN, Hobbs MV, Torbett BE, Glasebrook AL, Rehse MA, Bottomly K, Hayakawa K, Hardy RR, Weigle WO. Differences in the Expression Profiles of Cd45rb, Pgp-1, and 3g11 Membrane-Antigens and in the Patterns of Lymphokine Secretion by Splenic-Cd4+ T-Cells from Young and Aged Mice. Journal of Immunology. 1990 Sep;145(5):1295-302.
Hayakawa K. Autoreactivity and Cd5+ B-Cells. Current Opinion in Immunology. 1990 Apr;2(4):582-7.
Hayakawa K, Carmack CE, Hyman R, Hardy RR. Natural Autoantibodies to Thymocytes - Origin, Vh-Genes, Fine Specificities, and the Role of Thy-1 Glycoprotein. Journal of Experimental Medicine. 1990 Sep;172(3):869-78.
Holmes KL, Morse HC, Makino M, Hardy RR, Hayakawa K. A Unique Subset of Normal Murine Cd4+ T-Cells Lacking Thy-1 Is Expanded in a Murine Retrovirus-Induced Immunodeficiency Syndrome, Maids. European Journal of Immunology. 1990 Dec;20(12):2783-7.
Hardy RR, Kemp JD, Hayakawa K. Analysis of Lymphoid Population in Scid Mice - Detection of a Potential Lymphocyte-B Progenitor Population Present at Normal Levels in Scid Mice by 3 Color Flow-Cytometry with B220 and S7. Current Topics in Microbiology and Immunology. 1989 Jan;152:19-25.
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Last updated on Thursday, November 02, 2017