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Alfonso Bellacosa

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Center AffiliationsCancer Epigenetics

Publications (96) (print view)

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Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Thymine DNA glycosylase as a novel target for melanoma. Oncogene. 2019 May;38(19):3710-28.   PMCID: PMC6563616
Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip SC, Bassi MR, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol RW, Yen TJ, Bagella L, Bellacosa A. Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. DNA Repair. 2019 Oct;82:102687.   PMCID: PMC6785017
Bellacosa A, Yen T. Illuminating the route of precision medicine and inhibitor discovery: real-time measurement of DNA repair capacity with molecular beacons. Oncotarget. 2018 Dec 07;9(96):36818-9.   PMCID: PMC6305151
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Rep. 2018 Sep 25;24(13):3513-3527e7.   PMCID: PMC6219632
Peri S, Caretti E, Tricarico R, Devarajan K, Cheung M, Sementino E, Menges CW, Nicolas E, Vanderveer LA, Howard S, Conrad P, Crowell JA, Campbell KS, Ross EA, Godwin AK, Yeung AT, Clapper ML, Uzzo RG, Henske EP, Ricketts CJ, Vocke CD, Marston Linehan W, Testa JR, Bellacosa A, Kopelovich L, Knudson AG. Haploinsufficiency in tumor predisposition syndromes: Altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation. Oncotarget. 2017 Mar 14;8(11):17628-42.   PMCID: PMC5392274
Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017 Apr 19;94(2):337-346e6.
Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017 Apr 19;94(2):337-346e6.   PMCID: PMC6007997
Xu J, Cortellino S, Tricarico R, Chang WC, Scher G, Devarajan K, Slifker M, Moore R, Bassi MR, Caretti E, Clapper M, Cooper H, Bellacosa A. Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression. Oncotarget. 2017 Oct 27;8(52):89988-97.   PMCID: PMC5685726
Bellacosa A, Chernoff J, Testa JR. Alfred G. Knudson (1922-2016) Obituary. Cell. 2016 Aug;166(4):785-6.
Henry RA, Mancuso P, Kuo YM, Tricarico R, Tini M, Cole PA, Bellacosa A, Andrews AJ. Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300. Biochemistry. 2016 Dec 13;55(49):6766-75.   PMCID: PMC5206798
Peri S, Caretti E, Tricarico R, Devarajan K, Cheung M, Sementino E, Menges CW, Nicolas E, Vanderveer LA, Howard S, Conrad P, Crowell JA, Campbell KS, Ross EA, Godwin AK, Yeung AT, Clapper ML, Uzzo RG, Henske EP, Ricketts CJ, Vocke CD, Linehan WM, Testa JR, Bellacosa A, Kopelovich L, Knudson AG. Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation. Oncotarget. 2016 Sep 22;.
Bellacosa A, Drohat AC. Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites. DNA Repair (Amst). 2015 Aug;32:33-42.   PMCID: 4903958
Conde-Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, Viros A, Gesbert F, Delmas V, Rambow F, Bastian BC, Campbell AD, Colombo S, Puig I, Bellacosa A, Sansom O, Marais R, Van Kempen LC, Larue L. A caveolin-dependent and PI3K/AKT-independent role of PTEN in beta-catenin transcriptional activity. Nat Commun. 2015 Jan;6:8093.   PMCID: PMC4560817
Peretz Y, Wu H, Patel S, Bellacosa A, Katz RA. Inhibitor of DNA Binding 4 (ID4) Is Highly Expressed in Human Melanoma Tissues and May Function to Restrict Normal Differentiation of Melanoma Cells. PLoS One. 2015 Jan;10(2):e0116839.   PMCID: Pmc4314081
Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Moller P, Viel A, Genuardi M, Fodde R, Bellacosa A. Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. Oncotarget. 2015 Oct 16;6(40):42892-904.   PMCID: PMC4767479
Bellacosa A. Developmental disease and cancer: Biological and clinical overlaps. Am J Med Genet A. 2013 Nov;161(11):2788-96.
Gallagher SJ, Rambow F, Kumasaka M, Champeval D, Bellacosa A, Delmas V, Larue L. Beta-catenin inhibits melanocyte migration but induces melanoma metastasis. Oncogene. 2013 Apr 25;32(17):2230-8.   PMCID: Pmc3637425
Grigera F, Bellacosa A, Kenter AL. Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination. Plos One. 2013 Oct;8(10):e78370.   PMCID: PMC 3812156
Li P, Du F, Yuelling LW, Lin T, Muradimova RE, Tricarico R, Wang J, Enikolopov G, Bellacosa A, Wechsler-Reya RJ, Yang ZJ. A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nature Neuroscience. 2013 Dec;16(12):1737-44.   PMCID: PMC 3845444
Slupianek A, Falinski R, Znojek P, Stoklosa T, Flis S, Doneddu V, Pytel D, Synowiec E, Blasiak J, Bellacosa A, Skorski T. BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability. Leukemia. 2013 Mar;27(3):629-34.   PMCID: PMC3598941
Beeharry N, Rattner JB, Bellacosa A, Smith MR, Yen TJ. Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine. Plos One. 2012 Jan;7(6):e40342.   PMCID: PMC3386996
Dalton SR, Bellacosa A. DNA demethylation by TDG. Epigenomics. 2012 Aug;4(4):459-67.
Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A. Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair. Cell. 2011 Jul 08;146(1):67-79.   PMCID: PMC3230223 [available 2012/7/8]
Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HC, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L. APC +/- alters colonic fibroblast proteome in FAP. Oncotarget. 2011 Mar;2(3):197-208.   PMCID: PMC3195363
Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HS, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L. APC(+/-) alters colonic fibroblast proteome in FAP. Oncotarget. 2011 Mar;2(3):197-208.
Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila Pa). 2010 Jan;3(1):48-61.   PMCID: PMC2804937
Bruno T, Desantis A, Bossi G, Di Agostino S, Sorino C, De Nicola F, Iezzi S, Franchitto A, Benassi B, Galanti S, La Rosa F, Floridi A, Bellacosa A, Passananti C, Blandino G, Fanciulli M. Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation. Cancer cell. 2010 Aug;18(2):122-34.   PMCID: not NIH funded
Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G. At Increases Sarcoplasmic Reticulum Ca2+ Cycling by Direct Phosphorylation of Phospholamban at Thr(17). Journal of Biological Chemistry. 2009 Oct;284(41):28180-7.   PMCID: PMC2788869
Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A. Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev Biol. 2009 Jan;325(1):225-37.   PMCID: PMC2645042
Howard JH, Frolov A, Tzeng CW, Stewart A, Midzak A, Majmundar A, Godwin AK, Heslin MJ, Bellacosa A, Arnoletti P. Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer. Cancer Biology & Therapy. 2009 Jan;8(1):94-100.   PMCID: PMC2683899
Caretti E, Devarajan K, Coudry R, Ross E, Clapper ML, Cooper HS, Bellacosa A. Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection. Journal of cellular biochemistry. 2008 Feb;103(2):556-63.
Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Ibanez de Caceres I, Braunewell KH, Klein-Szanto AJ. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. PLoS ONE. 2008 Jan;3(2):e1698.   PMCID: PMC2246032
Sundermeyer M, Bellacosa A, Meropol N. Molecular Targeting of Colorectal Cancer. In: Antman K, Wadler S, editors. Molecular Targeting in Oncology . Totowa, NJ: Humana Press; 2008. p. 133-63.
Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A. One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. Cancer Res. 2008 Sep 15;68(18):7579-86.   PMCID: PMC2562578
Howard JH, Frolov A, Tzeng CD, Stewart A, Shlykova S, Heslin MJ, Bellacosa A, Arnoletti JP. Hypermethylation and suppression of DNA repair gene MED1 in sporadic human colorectal cancer. 2007 Jan;:14.
Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, Dargemont C, Garcia de Herreros A, Bellacosa A, Larue L. Activation of NF-kappa B by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene. 2007 Nov;26(53):7445-56.
Patel BB, Li XM, Dixon MP, Blagoi EL, Seeholzer SH, Chen Y, Miller CG, He YA, Tetruashvily M, Chaudhry AH, Ke E, Xie J, Cooper H, Bellacosa A, Clapper ML, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A, Yeung AT. Searchable high-resolution 2D gel proteome of the human colon crypt. J Proteome Res. 2007 Jun;6(6):2232-8.
Pimkin M, Caretti E, Canutescu A, Yeung JB, Cohn H, Chen Y, Oleykowski C, Bellacosa A, Yeung AT. Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection. BMC Biotechnol. 2007 Jan;7:29.   PMCID: PMC1896157
Turner DP, Cortellino S, Schupp JE, Caretti E, Loh T, Kinsella TJ, Bellacosa A. The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine. Cancer Res. 2006 Aug;66(15):7686-93.
Amoletti JP, Upson J, Babb JS, Bellacosa A, Watson JC. Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. Journal of Experimental & Clinical Cancer Research. 2005 Jun;24(2):279-87.
Bellacosa A, Kumar CC, Di Cristofano A, Testa JR. Activation of AKT kinases in cancer: implications for therapeutic targeting. Advances in cancer research. 2005 Jan;94:29-86.
Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3 ' kinase/AKT pathways. Oncogene. 2005 Nov;24(50):7443-54.
Bellacosa A, Testa JR, Moore R, Larue L. A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities. Cancer Biol Ther. 2004 Mar;3(3):268-75.
Cortellino S, Turner DP, Albino D, Bellacosa A. Induction of deoxyribonucleic acid damage by alkylating agents. Methods Mol Biol. 2004 Jan;285:121-5.
Cortellino S, Turner DP, Bellacosa A. Induction of deoxyribonucleic acid damage by gamma irradiation. Methods Mol Biol. 2004 Jan;285:127-32.
Stoyanova R, Clapper ML, Bellacosa A, Henske EP, Testa JR, Ross EA, Yeung AT, Nicolas E, Tsichlis N, Li YS, Linehan WM, Howard S, Campbell KS, Godwin AK, Boman BM, Crowell JA, Kopelovich L, Knudson AG. Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther. 2004 Dec;3(12):1313-21.
Stoyanova R, Upson JJ, Patriotis C, Ross EA, Henske EP, Datta K, Boman B, Clapper ML, Knudson AG, Bellacosa A. Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays. Journal of cellular physiology. 2004 Dec;201(3):359-65.
Turner DP, Yeung AT, Bellacosa A. Ultraviolet irradiation of cells. Methods Mol Biol. 2004 Jan;285:133-7.
Upson JJ, Stoyanova R, Cooper HS, Patriotis C, Ross EA, Boman B, Clapper ML, Knudson AG, Bellacosa A. Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection. Journal of cellular physiology. 2004 Dec;201(3):366-73.
Bellacosa A. Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention. Genes Chromosomes Cancer. 2003 Dec;38(4):382-8.
Bellacosa A, Moss EG. RNA repair: damage control. Curr Biol. 2003 Jun 17;13(12):R482-4.
Borgatti P, Martelli AM, Tabellini G, Bellacosa A, Capitani S, Neri LM. Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin. Journal of cellular physiology. 2003 Jul;196(1):79-88.
Cortellino S, Turner D, Masciullo V, Schepis F, Albino D, Daniel R, Skalka AM, Meropol NJ, Alberti C, Larue L, Bellacosa A. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci U S A. 2003 Dec 09;100(25):15071-6.   PMCID: PMC299910
Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, Larue L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Research. 2003 May;63(9):2172-8.
Neri LM, Borgatti P, Tazzari PL, Bortul R, Cappellini A, Tabellini G, Bellacosa A, Capitani S, Martelli AM. The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Molecular Cancer Research. 2003 Jan;1(3):234-46.
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu YS, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. 2002 Jan;:1125.
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu YS, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J. At induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 2002 Sep;99(19):12333-8.
Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nature medicine. 2002 Oct;8(10):1136-44.
Bellacosa A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell death and differentiation. 2001 Nov;8(11):1076-92.
Bellacosa A. Role of MED1 (MBD4) Gene in DNA repair and human cancer. Journal of cellular physiology. 2001 May;187(2):137-44.
Drummond JT, Bellacosa A. Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites. Nucleic acids research. 2001 Jun;29(11):2234-43.
Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):10983-5.   PMCID: PMC58668
Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A. 2001 Jan 02;98(1):247-52.   PMCID: PMC14576
Borgatti P, Martelli AM, Bellacosa A, Casto R, Massari L, Capitani S, Neri LM. Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. Febs Letters. 2000 Jul;477(1-2):27-32.
De Vita G, Berlingieri MT, Visconti R, Castellone MD, Viglietto G, Baldassarre G, Zannini M, Bellacosa A, Tsichlis PN, Fusco A, Santoro M. Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects. Cancer Research. 2000 Jul;60(14):3916-20.
De Vita G, Melillo RM, Carlomagno F, Visconti R, Castellone MD, Bellacosa A, Billaud M, Fusco A, Tsichlis PN, Santoro M. Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival. Cancer Research. 2000 Jul;60(14):3727-31.
Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Genuardi M, Karbowski M, Yeung AT, Matsumoto Y, Bellacosa A. Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain. Journal of cellular physiology. 2000 Dec;185(3):473-80.
Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Stoerker J, Genuardi M, Yeung AT, Matsumoto Y, Bellacosa A. Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase. The Journal of biological chemistry. 2000 Oct 20;275(42):32422-9.
Bellacosa A, Cicchillitti L, Schepis F, Riccio A, Yeung AT, Matsumoto Y, Golemis EA, Genuardi M, Neri G. MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3969-74.   PMCID: PMC22404
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK. The Akt kinase: Molecular determinants of oncogenicity. Proceedings of the National Academy of Sciences of the United States of America. 1998 Dec;95(25):14950-5.
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene. 1998 Jul 23;17(3):313-25.
Cattani P, Hohaus S, Bellacosa A, Genuardi M, Cavallo S, Rovella V, Almadori G, Cadoni G, Galli J, Maurizi M, Fadda G, Neri G. Association between cyclin D1 (CCND1) gene amplification and human papillomavirus infection in human laryngeal squamous cell carcinoma. Clinical Cancer Research. 1998 Nov;4(11):2585-9.
Eves EM, Xiong W, Bellacosa A, Kennedy SG, Tsichlis PN, Rosner MR, Hay N. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Molecular and Cellular Biology. 1998 Apr;18(4):2143-52.
Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase Akt-dependent pathway. Journal of Biological Chemistry. 1998 Nov;273(45):29864-72.
Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 1997 Apr;94(8):3627-32.
Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science (New York, NY). 1997 Jun;276(5320):1848-50.
Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, Hay N. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes & development. 1997 Mar;11(6):701-13.
Petrukhin L, Dangel J, Vanderveer L, Costalas J, Bellacosa A, Grana G, Daly M, Godwin AK. The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. Cancer Res. 1997 Dec 15;57(24):5480-4.
Skorski T, Bellacosa A, NieborowskaSkorska M, Majewski M, Martinez R, Choi JK, Trotta R, Wlodarski P, Perrotti D, Chan TO, Wasik MA, Tsichlis PN, Calabretta B. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO Journal. 1997 Oct;16(20):6151-61.
Testa JR, Bellacosa A. Membrane translocation and activation of the Akt kinase in growth factor-stimulated hematopoietic cells. Leuk Res. 1997 Nov;21(11-12):1027-31.
Datta K, Bellacosa A, Chan TO, Tsichlis PN. Akt is a direct target of the phosphatidylinositol 3-kinase - Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. Journal of Biological Chemistry. 1996 Nov;271(48):30835-9.
Datta K, Bellacosa A, Chan TO, Tsichlis PN. Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. The Journal of biological chemistry. 1996 Nov 29;271(48):30835-9.
Hohaus S, Cavallo S, Bellacosa A, Genuardi M, Galli J, Cadoni G, Almadori G, Lauriola L, Litwin S, Maurizi M, Neri G. Telomerase activity in human laryngeal squamous cell carcinomas. Clinical Cancer Research. 1996 Nov;2(11):1895-900.
Lissy NA, Bellacosa A, Sonoda G, Miller PD, Jhanwar SC, Testa JR. Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC. Biochimica et biophysica acta. 1996 May 02;1306(2-3):137-41.
Bellacosa A, Defeo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan MH, Dubeau L, Scambia G, Masciullo V, Ferrandina G, Panici PB, Mancuso S, Neri G, Testa JR. MOLECULAR ALTERATIONS OF THE AKT2 ONCOGENE IN OVARIAN AND BREAST CARCINOMAS. International journal of cancer. 1995 Aug;64(4):280-5.
Breuninger LM, Paul S, Gaughan K, Miki T, Chan A, Aaronson SA, Kruh GD. Expression of Multidrug Resistance-Associated Protein in Nih/3t3 Cells Confers Multidrug-Resistance Associated with Increased Drug Efflux and Altered Intracellular Drug Distribution. Cancer Research. 1995 Nov 15;55(22):5342-7.
Bellacosa A, Datta K, Bear SE, Patriotis C, Lazo PA, Copeland NG, Jenkins NA, Tsichlis PN. Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA. J Virol. 1994 Apr;68(4):2320-30.   PMCID: PMC236708
Ahmed NN, Franke TF, Bellacosa A, Datta K, Gonzalez-Portal ME, Taguchi T, Testa JR, Tsichlis PN. The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene. 1993 Jul;8(7):1957-63.
Bellacosa A, Franke TF, Gonzalezportal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN. STRUCTURE, EXPRESSION AND CHROMOSOMAL MAPPING OF C-AKT - RELATIONSHIP TO V-AKT AND ITS IMPLICATIONS. Oncogene. 1993 Mar;8(3):745-54.
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. 1993 Mar;8(3):745-54.
Taguchi T, Bellacosa A, Zhou JY, Gilbert DJ, Lazo PA, Copeland NG, Jenkins NA, Tsichlis PN, Testa JR. Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents. Cytogenet Cell Genet. 1993 Jan;64(3-4):217-21.
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A. 1992 Oct;89(19):9267-71.   PMCID: PMC50107
Bellacosa A, Lazo PA, Bear SE, Tsichlis PN. The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation. Mol Cell Biol. 1991 May;11(5):2864-72.   PMCID: PMC360073
Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science (New York, NY). 1991 Oct 11;254(5029):274-7.
Bear SE, Bellacosa A, Lazo PA, Jenkins NA, Copeland NG, Hanson C, Levan G, Tsichlis PN. Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7495-9.   PMCID: PMC298091
Bellacosa A, Lazo PA, Bear SE, Shinton S, Tsichlis PN. Induction of multiple independent T-cell lymphomas in rats inoculated with MOloney murine leukemia virus. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4269-72.   PMCID: PMC287432
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Last updated on Saturday, August 22, 2020