Faculty Publications

Somaiah N, von Mehren M

New therapeutic approaches for advanced gastrointestinal stromal tumors

Hematol Oncol Clin North Am. 2009 Feb;23(1):139-50.

Abstract The management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.