Faculty Publications
Strategies for identification of HIV-1 integrase inhibitors
Strategies for identification of HIV-1 integrase inhibitors
Future Virology. 2006 Nov;1(6):717-31.
Abstract HIV-1 integrase, which catalyzes the joining of viral DNA to the host cell DNA, has attracted considerable attention as a target for the design and screening of novel anti-HIV drugs as it is essential for virus replication and the establishment of persistent infection. Progress in the identification of different classes of compounds that block integrase activity has been summarized recently in several excellent reviews. Here, we present a brief overview of integrase inhibition, highlighting some of the unusual properties of this protein and important considerations in searching for potential new inhibitors and their evaluation.