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Publication Listing for the MeSH term Structure-Activity Relationship. Found 19 abstracts

de Oliveira JF, Lima TS, Vendramini-Costa DB, de Lacerda Pedrosa SC, Lafayette EA, da Silva RM, de Almeida SM, de Moura RO, Ruiz A, de Carvalho JE, de Lima M. Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay. European journal of medicinal chemistry. 2017 Aug 18;136:305-14.
Dong Z, Shanmughapriya S, Tomar D, Siddiqui N, Lynch S, Nemani N, Breves SL, Zhang X, Tripathi A, Palaniappan P, Riitano MF, Worth AM, Seelam A, Carvalho E, Subbiah R, Jana F, Soboloff J, Peng Y, Cheung JY, Joseph SK, Caplan J, Rajan S, Stathopulos PB, Madesh M. Mitochondrial Ca(2+) Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity. Molecular cell. 2017 Mar 16;65(6):1014-1028e7.   PMCID: PMC5357178
Malhotra S, Karanicolas J. When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?. Journal of medicinal chemistry. 2017 Jan 12;60(1):128-45.   PMCID: PMC5525026
Solinski AE, Koval AB, Brzozowski RS, Morrison KR, Fraboni AJ, Carson CE, Eshraghi AR, Zhou G, Quivey RG, Voelz VA, Buttaro BA, Wuest WM. Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms. J Am Chem Soc. 2017 May 31;139(21):7188-91.   PMCID: PMC5891724
Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein science : a publication of the Protein Society. 2016 Nov;25(11):1911-7.   PMCID: PMC5079246
Wagner J, Kline CL, Pottorf RS, Nallaganchu BR, Olson GL, Dicker DT, Allen JE, El-Deiry WS. The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity. Oncotarget. 2014 Dec 30;5(24):12728-37.   PMCID: PMC4350349
Maximov PY, Myers CB, Curpan RF, Lewis-Wambi JS, Jordan VC. Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen. Journal of medicinal chemistry. 2010 Apr 22;53(8):3273-83.   PMCID: PMC2867604
Markham GD, Pajares MA. Structure-function relationships in methionine adenosyltransferases. Cellular and molecular life sciences : CMLS. 2009 Feb;66(4):636-48.   PMCID: PMC2643306
Reitz AB, Smith GR, Tounge BA, Reynolds CH. Hit triage using efficiency indices after screening of compound libraries in drug discovery. Curr Top Med Chem. 2009 Jan;9(18):1718-24.
Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR. Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. The Journal of biological chemistry. 2007 May 25;282(21):15667-78.
Stoyanova R, Nicholson JK, Lindon JC, Brown TR. Sample classification based on Bayesian spectral decomposition of metabonomic NMR data sets. Analytical Chemistry. 2004 Jul;76(13):3666-74.
Kundrat L, Martins J, Stith L, Dunbrack RL, Jaffe EK. A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase. The Journal of biological chemistry. 2003 Aug 15;278(33):31325-30.
Toby GG, Gherraby W, Coleman TR, Golemis EA. A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels. Mol Cell Biol. 2003 Mar;23(6):2109-22.
Cirillo LA, Lin FR, Cuesta I, Friedman D, Jarnik M, Zaret KS. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Molecular cell. 2002 Feb;9(2):279-89.
Asante-Appiah E, Skalka AM. HIV-1 integrase: structural organization, conformational changes, and catalysis. Adv Virus Res. 1999 Jan;52:351-69.
Shan X, Wang L, Hoffmaster R, Kruger WD. Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae. The Journal of biological chemistry. 1999 Nov 12;274(46):32613-8.
Datta K, Bellacosa A, Chan TO, Tsichlis PN. Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. The Journal of biological chemistry. 1996 Nov 29;271(48):30835-9.
Carrell CJ, Carrell HL, Glusker JP, Abu-Shaqara E, Cortez C, Harvey RG. Bay- and fjord-region distortions in dibenz[a,j]anthracene and tetrabenzo[de,hi,mn,qr]naphthacene. Carcinogenesis. 1994 Dec;15(12):2931-6.
Reimer NS, Yasunobu CL, Yasunobu KT, Norton TR. Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin-B. Journal of Biological Chemistry. 1985 Jul 25;260(15):8690-3.
The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

MeSH cloud from publications including the MeSH term Structure-Activity Relationship

Structure-Activity Relationship chemistry metabolism pharmacology genetics US Gov't Support-PHS physiology Molecular Models Molecular Structure Non-US Gov't Support Animal enzymology drug effects X-Ray Crystallography Mice Post-Translational Protein Processing Drug Dose-Response Relationship chemical synthesis Tumor Cell Line Human Protein Conformation Amino Acid Motifs Cell Cycle Proteins Female Protein Multimerization Mutation DNA-Binding Proteins Liver Protein-Serine-Threonine Kinases Saccharomyces cerevisiae HIV-1 Species Specificity Genetic Complementation Test cytology Time Factors Binding Sites Comparative Study Amino Acid Sequence Cell Proliferation Phosphorylation Tertiary Protein Structure Cell Line HIV Integrase Molecular Conformation Cell Death Antineoplastic Agents Phenotype Molecular Sequence Data Male ur [Urine] Heterocyclic Compounds with 4 or More Rings Sequence Alignment me [Metabolism] 1-Phosphatidylinositol 3-Kinase bioenergetics Naphthacenes Enzymologic Gene Expression Regulation Medicinal chemistry Zinc Fingers Tamoxifen HIV Integrase Inhibitors agonists Wistar Rats Benzanthracenes Proto-Oncogene Proteins c-akt Protein Folding derivatives Amino Acid Sequence Homology Oxidation-Reduction Chemical Models Drug Toxicity Macrolides Proto-Oncogene Proteins Porphobilinogen Synthase Zinc HeLa Cells classification Estrogen Antagonists 0 (Hydrazines) Nuclear Proteins Enzyme Activation Neurofibromin 1 Fungal Gene Expression Regulation Enzyme Stability Metaphase Endoderm Oncogene Protein pp60(v-src) protein-ligand binding Reproducibility of Results 3T3 Cells Reactive Oxygen Species calcium Rats mitochondria Methionine rho GTP-Binding Proteins Anticancer therapy Recombinant Fusion Proteins Breast Neoplasms Peptide Fragments Thiosemicarbazones COS Cells pathology Small Molecule Libraries cdc42 GTP-Binding Protein Glutathione Emre Two-Hybrid System Techniques Molecular Weight Type II DNA Topoisomerases embryology Site-Directed Mutagenesis Magnetic Resonance Imaging Developmental Gene Expression Regulation Methionine Adenosyltransferase reactive oxygen species Topoisomerase inhibition G2 Phase Macromolecular Systems Growth Substances Drosophila melanogaster Histones Micu1 growth & development S-Adenosylmethionine Gene Silencing Energy Metabolism Cyclin B biosynthesis Preclinical Drug Evaluation Oocytes Cell Hypoxia Stereoisomerism Topoisomerase Inhibitors protein-protein docking Isoenzymes Biofilms methods Allosteric Regulation HEK293 Cells Cell Division Cell Survival Gene Library Streptococcus mutans Cellular death Protein Structural Homology Drug Design ad [Administration & Dosage] Calcium Channels Ligands
Last updated on Wednesday, February 05, 2020