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Publication Listing for the MeSH term Porphobilinogen Synthase. Found 14 abstracts

Jaffe EK, Lawrence SH. Allostery and the dynamic oligomerization of porphobilinogen synthase. Archives of biochemistry and biophysics. 2012 Mar 15;519(2):144-53.   PMCID: PMC3291741
Ramirez UD, Myachina F, Stith L, Jaffe EK. Docking to large allosteric binding sites on protein surfaces. Advances in experimental medicine and biology. 2010 Jan;680:481-8.   PMCID: PMC2946403
Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK. Allosteric inhibition of human porphobilinogen synthase. The Journal of biological chemistry. 2009 Dec 18;284(51):35807-17.   PMCID: 2791010
Selwood T, Tang L, Lawrence SH, Anokhina Y, Jaffe EK. Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase. Biochemistry. 2008 Mar 11;47(10):3245-57.
Tang L, Breinig S, Stith L, Mischel A, Tannir J, Kokona B, Fairman R, Jaffe EK. Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins). The Journal of biological chemistry. 2006 Mar 10;281(10):6682-90.
Kundrat L, Martins J, Stith L, Dunbrack RL, Jaffe EK. A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase. The Journal of biological chemistry. 2003 Aug 15;278(33):31325-30.
Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A. Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid. The Journal of biological chemistry. 2002 May 31;277(22):19792-9.
Jaffe EK, Martins J, Li J, Kervinen J, Dunbrack RL. The molecular mechanism of lead inhibition of human porphobilinogen synthase. The Journal of biological chemistry. 2001 Jan 12;276(2):1531-7.
Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A. Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity. Biochemistry. 2001 Jul 27;40(28):8227-36.
Mitchell LW, Volin M, Martins J, Jaffe EK. Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase. The Journal of biological chemistry. 2001 Jan 12;276(2):1538-44.
Jaffe EK. The porphobilinogen synthase family of metalloenzymes. Acta Crystallogr D Biol Crystallogr. 2000 Feb;56 ( Pt 2):115-28.
Jaffe EK, Volin M, Bronson-Mullins CR, Dunbrack RL, Kervinen J, Martins J, Quinlan JF, Sazinsky MH, Steinhouse EM, Yeung AT. An artificial gene for human porphobilinogen synthase allows comparison of an allelic variation implicated in susceptibility to lead poisoning. The Journal of biological chemistry. 2000 Jan 28;275(4):2619-26.
Kervinen J, Dunbrack RL, Litwin S, Martins J, Scarrow RC, Volin M, Yeung AT, Yoon E, Jaffe EK. Porphobilinogen synthase from pea: expression from an artificial gene, kinetic characterization, and novel implications for subunit interactions. Biochemistry. 2000 Aug;39(30):9018-29.
Shimoni-Livny L, Carrell HL, Wagner T, Kaufman Katz A, Afshar C, Mitchell LW, Volin M, Jaffe EK, Glusker JP. Crystallization and preliminary X-ray diffraction studies of E. coli porphobilinogen synthase and its heavy-atom derivatives. Acta Crystallogr D Biol Crystallogr. 1998 May;54 ( Pt 3):438-40.
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MeSH cloud from publications including the MeSH term Porphobilinogen Synthase

Porphobilinogen Synthase chemistry metabolism US Gov't Support-PHS enzymology Kinetics Non-US Gov't Support Molecular Sequence Data Molecular Models genetics Human Quaternary Protein Structure Amino Acid Sequence Escherichia coli Binding Sites Site-Directed Mutagenesis Enzyme Inhibitors Recombinant Proteins pharmacology Zinc drug effects antagonists & inhibitors Amino Acid Substitution Hydrogen-Ion Concentration Tertiary Protein Structure Peas Enzyme Stability Species Specificity Decanoic Acids Catalysis Synthetic Genes X-Ray Crystallography Animal Allosteric Regulation Protein Conformation Crystallization Comparative Study Amino Acid Sequence Homology Lead Poisoning Magnesium Variation (Genetics) Complementary DNA Competitive Binding Mutation Cysteine Electrons Enzyme Activation Protein Binding physiology Drug Dose-Response Relationship inhibitors Dimerization Metalloproteins Genetic Predisposition to Disease Computational Biology Divalent Cations Biomolecular Nuclear Magnetic Resonance Arginine Agarose Chromatography Heptanoates Sequence Deletion Protein Multimerization Nucleic Acid Sequence Homology Lead Yersinia enterocolitica Secondary Protein Structure Conserved Sequence Molecular Weight antagonists & Agar Gel Electrophoresis isolation & purification Substrate Specificity Drosophila melanogaster Base Sequence Protein Subunits Structure-Activity Relationship biosynthesis X-Ray Diffraction Isoenzymes Mutagenesis Thermodynamics Allosteric Site Enzymologic Gene Expression Regulation Software Ligands Proteins Schiff Bases Porphyrias Tryptophan Porphobilinogen Chemical Models Alleles Lysine Plant Proteins Drug Discovery Polymerase Chain Reaction
Last updated on Thursday, June 04, 2020