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Publication Listing for the MeSH term Drug Discovery. Found 10 abstracts

Stout MC, Campbell PM. RASpecting the oncogene: New pathways to therapeutic advances. Biochemical pharmacology. 2018 Dec;158:217-28.
Brzozowski RS, Wuest WM. Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics. Chemical biology & drug design. 2017 Feb;89(2):169-91.   PMCID: Review
Liu B, Tang L, Zhang X, Ma J, Sehgal M, Cheng J, Zhang X, Zhou Y, Du Y, Kulp J, Guo JT, Chang J. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists. Antiviral research. 2017 Nov;147:37-46.   PMCID: PMC5789800
Boushra M, Tous S, Fetih G, Korzekwa K, Lebo DB, Xue HY, Wong HL. Development and evaluation of viscosity-enhanced nanocarrier (VEN) for oral insulin delivery. International journal of pharmaceutics. 2016 Sep 10;511(1):462-72.
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of biological chemistry. 2016 Nov 04;291(45):23569-77.   PMCID: PMC5095411
Abou-Gharbia M, Childers WE. Discovery of innovative therapeutics: today's realities and tomorrow's vision. 1. Criticisms faced by the pharmaceutical industry. J Med Chem. 2013 Jul 25;56(14):5659-72.
Astsaturov I, Ratushny V, Sukhanova A, Einarson MB, Bagnyukova T, Zhou Y, Devarajan K, Silverman JS, Tikhmyanova N, Skobeleva N, Pecherskaya A, Nasto RE, Sharma C, Jablonski SA, Serebriiskii IG, Weiner LM, Golemis EA. Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Science signaling. 2010 Jan;3(140):ra67.   PMCID: PMC2950064
Cohen AD, Comenzo RL. Systemic light-chain amyloidosis: advances in diagnosis, prognosis, and therapy. Hematology Am Soc Hematol Educ Program. 2010 Jan;2010:287-94.   PMCID: not NIH funded
Ramirez UD, Myachina F, Stith L, Jaffe EK. Docking to large allosteric binding sites on protein surfaces. Advances in experimental medicine and biology. 2010 Jan;680:481-8.   PMCID: PMC2946403
Reitz AB, Smith GR, Tounge BA, Reynolds CH. Hit triage using efficiency indices after screening of compound libraries in drug discovery. Curr Top Med Chem. 2009 Jan;9(18):1718-24.
The above publications are sorted by year, faculty last name, and first author. Click on any highlighted author listed to find all publications attributed to that individual. Click on the publication title to see the abstract. First authors who are faculty are highlighted like this. Last authors who are faculty are highlighted like this. Other authors who are faculty are highlighted like this.

MeSH cloud from publications including the MeSH term Drug Discovery

Drug Discovery chemistry metabolism pharmacology methods drug effects Molecular Models drug therapy antagonists & Cell Survival Signal Transduction Preclinical Drug Evaluation genetics inhibitors antagonists & inhibitors Developing Countries Catalytic Domain HIV Integrase Flavivirus Transcription Factors administration & dosage Molecular Weight X-ray crystallography integrase Mice X-Ray Crystallography Antiviral Agents Encapsulation efficiency macrolactone drug screening Piperazines Enzyme Inhibitors diverted total synthesis HIV-1 integrase Spiro Compounds natural product Quaternary Protein Structure Protein Subunits therapy Sprague-Dawley Rats Nanoparticles High throughput assay Structure-Activity Relationship biosynthesis Amyloidosis Drug Carriers Cultured Cells Hiv-1 Protein-Serine-Threonine Kinases Gene Expression Generic Drugs Biological Products Epidermal Growth Factor Receptor Neoplasms Oral Administration Allosteric Regulation Male HEK293 Cells Insulin Allosteric Site Solid lipid nanoparticles Combination Drug Therapy HIV Infections Random Allocation Drug Design virology RNA Interference Prognosis HIV Integrase Inhibitors Neoplasm Drug Resistance agonists Proteins human immunodeficiency virus (HIV) Ras Innate immune Protein Interaction Mapping chemical synthesis medicinal chemistry Nucleotidyltransferases Antiviral Macrolides Porphobilinogen Synthase Sting antibiotic High-Throughput Screening Assays Innate Immunity Lethal Dose 50 diagnosis Mutation classification Viscosity Oral delivery economics Cancer Plasma Cells enzymology Molecular Docking Simulation physiology Drug Dose-Response Relationship Enzyme Stability Signaling Species Specificity Therapeutics Membrane Proteins Protein Kinase C Drug Costs Computational Biology Drug Industry Propylene glycol allosteric inhibitor drug discovery Interferon Inducers Lactones Rats Thiophenes Immunoglobulin Light Chains Peptide Theoretical Models Small Interfering RNA Cytotoxins Drug Delivery Systems fragment screening Virus Replication Caco-2 Cells STAT3 Transcription Factor Yersinia enterocolitica Small Molecule Libraries pathology HIV-1 Carboxylic Acids
Last updated on Wednesday, February 05, 2020