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Publication Listing for the MeSH term Allosteric Regulation. Found 8 abstracts

Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein science : a publication of the Protein Society. 2016 Nov;25(11):1911-7.   PMCID: PMC5079246
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of biological chemistry. 2016 Nov 04;291(45):23569-77.   PMCID: PMC5095411
Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19;22(11):1491-504.   PMCID: PMC4701204
Vijayan RS, He P, Modi V, Duong-Ly KC, Ma HC, Peterson JR, Dunbrack RL, Levy RM. Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors. Journal of medicinal chemistry. 2015 Jan;58(1):466-79.   PMCID: 4326797
Jaffe EK, Lawrence SH. Allostery and the dynamic oligomerization of porphobilinogen synthase. Archives of biochemistry and biophysics. 2012 Mar 15;519(2):144-53.   PMCID: PMC3291741
Selwood T, Jaffe EK. Dynamic dissociating homo-oligomers and the control of protein function. Archives of biochemistry and biophysics. 2012 Mar 15;519(2):131-43.   PMCID: PMC3298769
Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK. Allosteric inhibition of human porphobilinogen synthase. The Journal of biological chemistry. 2009 Dec 18;284(51):35807-17.   PMCID: 2791010
Viaud J, Peterson JR. An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther. 2009 Sep;8(9):2559-65.   PMCID: 2782767
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MeSH cloud from publications including the MeSH term Allosteric Regulation

Allosteric Regulation metabolism chemistry drug effects Quaternary Protein Structure Protein Multimerization pharmacology Molecular Models Small Molecule Libraries Porphobilinogen Synthase inhibitors HIV-1 integrase enzymology HIV-1 Amino Acid Sequence HIV Integrase Inhibitors Protein Binding Cell Line HIV Integrase Protein Kinase Inhibitors antagonists & Disulfides X-Ray Crystallography Cell Proliferation drug screening Molecular Structure antagonists & DNA Damage isolation & purification deficiency high-throughput screening Rad52 DNA Repair and Recombination Protein Protein Conformation BRCA2 Protein Protein Databases Molecular Docking Simulation genetics physiology analogs & derivatives synthetic lethality Enzyme Stability Structure-Activity Relationship Dihydroxyphenylalanine biosynthesis Hiv-1 protein-ligand binding p21-Activated Kinases protein-protein docking Lead Poisoning allosteric inhibitor drug discovery Inhibitory Concentration 50 Neoplasms Molecular Sequence Data single-strand annealing HEK293 Cells Allosteric Site genome instability HIV Infections Protein Kinases virology RNA Interference Ligands Single-Stranded DNA Recombinant Proteins cancer therapeutics cancer Proteins Fluorescence Spectrometry Apoptosis human immunodeficiency virus (HIV) Porphyrias medicinal chemistry allosteric HIV-1 integrase inhibitor BRCA1 Protein Chemical Models homologous recombination Electrophoretic Mobility Shift Assay Drug Discovery Fluorescence Microscopy Biocatalysis Thiophenes Small Interfering RNA toxicity fragment screening Proteome Naphthols Amino Acid Motifs DNA repair drug therapy pathology antagonists & inhibitors Carboxylic Acids Catalytic Domain Tertiary Protein Structure Binding Sites X-ray crystallography integrase
Last updated on Friday, January 03, 2020