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Lobo A, Naso A, Arheart K, Kruger WD, Abou-Ghazala T, Alsous F, Nahlawi M, Gupta A, Moustapha A, van Lente F, Jacobsen DW, Robinson K
Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B-6 and B-12
American Journal of Cardiology (1999) 83:821-825.
Abstract
An increased plasma homocysteine concentration is a risk factor for atherosclerosis. Folic acid lowers homocysteine but the optimal dose in patients with coronary artery disease (CAD) is unclear. This placebo-controlled, single-blind, dose-ranging study evaluates the effect of low-dose folic acid on homocysteine levels in 95 patients aged 61 +/- 11 years (mean +/- SD) with documented CAD. Patients in each group were given either placebo or 1 of 3 daily supplements of folic acid (400 mu g, 1 mg, or 5 mg) for 3 months. Each active treatment arm also received 500 mu g vitamin B-12 and 12.5 mg vitamin Bg. Total plasma homocysteine levels were measured after 30 and 90 days. Folic acid 400 mu g reduced homocysteine levels from 13.8 +/- 8.8 to 9.6 +/- 2.0 mu mol/L at 90 days (p = 0.001). On 1- and 5-mg folic acid, levels decreased from 13.0 +/- 6.4 to 9.8 +/- 4.0 mu mol/L (p = 0.001) and from 14.8 +/- 8.9 to 9.7 +/- 3.3 mu mol/L (p <0.001), respectively. The decrease was similar in all treatment groups. There was no significant change with placebo. Although the sample size is small, these findings suggest that daily administration of 400 mu g/day folic acid combined with vitamin B-12 and vitamin B-6 may be equivalent to higher doses in reducing homocysteine levels in patients with CAD. (C) 1999 by Excerpta Medica, Inc.
Note
Publication Date: 1999-03-15.
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