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Lee SY, Stadanlick J, Kappes DJ, Wiest DL
Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice
Semin Immunol (2010) 22:237-46.
While insights into the molecular processes that specify adoption of the alphabeta and gammadelta fates are beginning to emerge, the basis for control of specification remains highly controversial. This review highlights the current models attempting to explain T lineage commitment. Recent observations support the hypothesis that the T cell receptor (TCR) provides instructive cues through differences in TCR signaling intensity and/or longevity. Accordingly, we review evidence addressing the importance of differences in signal strength/longevity, how signals differing in intensity/longevity may be generated, and finally how such signals modulate the activity of downstream effectors to promote the opposing developmental fates.
Publication Date: 2010-08-01.
PMCID: PMC2906684
Last updated on Saturday, June 06, 2020